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Chalk River Laboratories

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About: Chalk River Laboratories is a based out in . It is known for research contribution in the topics: Neutron diffraction & Neutron scattering. The organization has 2297 authors who have published 2700 publications receiving 73287 citations.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors extracted charge and transverse energy distributions for intermediate mass fragments for central Kr1Au collisions at E/A5352400 MeV and showed that the slopes of the measured fragment charge distributions decrease monotonically with incident energy, consistent with the expectations for highly charged systems.
Abstract: Charge and transverse energy distributions for intermediate mass fragments have been extracted for central Kr1Au collisions at E/A5352400 MeV. The slopes of the measured fragment charge distributions decrease monotonically with incident energy, consistent with the expectations for highly charged systems, but not with recent critical exponent analyses. Statistical model calculations, which reproduce the experimental trends, suggest that post-breakup fragment secondary decays alter significantly the observed charge distributions. Radial expansion velocities extracted from these calculations follow the systematics of Au1Au collisions. @S0556-2813~97!50205-6#

36 citations

Journal ArticleDOI
TL;DR: Experimental evidence for a long-range protein-protein interaction in purple membrane (PM) is presented and the effective spring constant for the interaction between neighboring protein trimers is determined to be k = 53 N/m.
Abstract: We present experimental evidence for a long-range protein-protein interaction in purple membrane (PM). The interprotein dynamics were quantified by measuring the spectrum of the acoustic phonons in the 2D bacteriorhodopsin (BR) protein lattice using inelastic neutron scattering. Phonon energies of about 1 meV were determined. The data are compared to an analytical model, and the effective spring constant for the interaction between neighboring protein trimers are determined to be k ¼ 53 N=m. Additional, optical-like excitations at 0.45 meV were found and assigned to intraprotein dynamics between neighboring BR monomers.

36 citations

Journal ArticleDOI
TL;DR: In this paper, the solid solubility of Nb in α-Zr is an important parameter that has a potential impact on the corrosion properties of Zr-Nb alloys at reactor operating temperatures, i.e. below the monotectoid temperature.

36 citations

Journal ArticleDOI
TL;DR: Examination of in vitro responses to a model environmental carcinogen of six non-tumor skin fibroblast strains from HCMM/DNS patients representing five families points to a metabolic anomaly which may contribute to the carcinogenic risk of the melanoma prone preneoplastic state presented by some DNS patients.
Abstract: The dysplastic nevus syndrome (DNS) is a preneoplastic melanocyte abnormality which occurs in families affected by hereditary cutaneous malignant melanoma (HCMM). A putative role of host-environmental interactions in the etiology of hereditary melanoma has been strengthened by the recent finding that fibroblasts derived from HCMM/DNS patients demonstrated enhanced sensitivity to u.v.-irradiation in vitro. We report here an extension of these studies in which we have examined the in vitro responses to a model environmental carcinogen, 4-nitroquinoline 1-oxide (4NQO), of six non-tumor skin fibroblast strains from HCMM/DNS patients representing five families. Three of the six HCMM/DNS strains showed enhanced cell killing with sensitivities greater than that of a xeroderma pigmentosum (XP) variant strain but less than those of ataxia telangiectasia and XP Group D cell strains. The inhibition and recovery of de novo DNA synthesis, together with the expression of repair synthesis, following 4NQO exposure appeared to be normal in HCMM/DNS strains, irrespective of their subsequent clonogenic potential. Our data point to a metabolic anomaly which may contribute to the carcinogenic risk of the melanoma prone preneoplastic state presented by some DNS patients.

36 citations


Authors

Showing all 2298 results

NameH-indexPapersCitations
Michael D. Guiver7828820540
Robert J. Birgeneau7858722686
Mike D. Flannigan7121121327
Martin T. Dove6139614767
Luis Rodrigo5834112963
André Longtin5626016372
David Mitlin5619615479
John Katsaras552209263
John E. Greedan5539112171
Gang Li484067713
Matthew G. Tucker452247288
Bruce D. Gaulin452846698
Erick J. Dufourc431445882
Norbert Kučerka431197319
Stephen J. Skinner421948522
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
202284
202176
202072
201974
2018104