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TL;DR: The in vitro radiation responses of six non‐tumor skin fibroblast strains from HCMM/DNS patients representing five families are studied and are consistent with the hypothesis that the genetically determined predisposition to malignant melanoma may directly or indirectly be the consequence of increased susceptibility to UV‐induced cellular damage.
Abstract: The dysplastic nevus syndrome (DNS) is a preneoplastic melanocyte abnormality which occurs in families affected by hereditary cutaneous malignant melanoma (HCMM). Although environmental exposures, especially solar UV-irradiation, have been implicated as risk factors in sporadic melanoma, the role of such exposures in the pathogenesis of HCMM is unknown. We have studied the in vitro radiation responses of six non-tumor skin fibroblast strains from HCMM/DNS patients representing five families. All six HCMM/DNS strains were found to show some degree of enhanced cell killing sensitivity, compared with normal controls, following 254 nm UV-irradiation. The abnormal survival responses appeared to relate to specific characteristics of HCMM/DNS cells since the six strains had essentially normal sensitivity to gamma-radiation. The enhanced photosensitivity was not associated with abnormal patterns in either DNA repair synthesis or UV-induced inhibition and recovery of de novo DNA synthesis. The survival results are consistent with the hypothesis that the genetically determined predisposition to malignant melanoma may directly or indirectly be the consequence of increased susceptibility to UV-induced cellular damage.
74 citations
TL;DR: Consideration of the epidemiological evidence on radiogenic lung cancer in uranium miners and of the incidence of the disease generally leads to an upper estimate for the lifetime risk of 10−4 cases per working level month for the general population.
Abstract: Consideration of the epidemiological evidence on radiogenic lung cancer in uranium miners and of the incidence of the disease generally leads to an upper estimate for the lifetime risk of 10−4 cases per working level month for members of the general population.
74 citations
TL;DR: Molecular dynamics simulations and experiment are used to develop a one-dimensional scattering density profile (SDP) model suitable for the analysis of experimental data and the direct comparison of simulated-to-experimental data gives rise to the detailed structure of POPG bilayers.
73 citations
TL;DR: In this article, a production route can be specified to achieve the desirable texture of basal plane normals oriented radially in the tube, and the texture developed is controlled by the direction of major strain in the final stages of fabrication.
73 citations
TL;DR: The number of somatic embryos produced was significantly higher on medium solidified with Gelrite gellan gum than with Difco Bacto-agar, and the number of germinating embryos was produced when the embryogenic tissue was maintained in darkness, followed by a maturation stage in light.
72 citations
Authors
Showing all 2298 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Michael D. Guiver | 78 | 288 | 20540 |
| Robert J. Birgeneau | 78 | 587 | 22686 |
| Mike D. Flannigan | 71 | 211 | 21327 |
| Martin T. Dove | 61 | 396 | 14767 |
| Luis Rodrigo | 58 | 341 | 12963 |
| André Longtin | 56 | 260 | 16372 |
| David Mitlin | 56 | 196 | 15479 |
| John Katsaras | 55 | 220 | 9263 |
| John E. Greedan | 55 | 391 | 12171 |
| Gang Li | 48 | 406 | 7713 |
| Matthew G. Tucker | 45 | 224 | 7288 |
| Bruce D. Gaulin | 45 | 284 | 6698 |
| Erick J. Dufourc | 43 | 144 | 5882 |
| Norbert Kučerka | 43 | 119 | 7319 |
| Stephen J. Skinner | 42 | 194 | 8522 |