Chalk River Laboratories

About: Chalk River Laboratories is a based out in . It is known for research contribution in the topics: Neutron diffraction & Neutron scattering. The organization has 2297 authors who have published 2700 publications receiving 73287 citations.

Fast Neutron Spectroscopy Using ${\rm Cs}_{2}{\rm LiYCl}_{6}{:}{\rm Ce}$ (CLYC) Scintillator

Abstract: The response of Cs2LiYCl6:Ce (CLYC) scintillator material to fast neutrons has been measured using a Van de Graaff accelerator. Beams of monoenergetic neutrons in the energy range 0.359 MeV to 4.703 MeV were used to irradiate a 9 mm × 9.5 mm × 12 mm CLYC crystal. Following pulse-shape discrimination to separate neutron and gamma-ray events, peaks are observed in the neutron spectrum and assigned to fast-neutron events in the scintillator. One of the peaks is interpreted as being due to the 35Cl(n, p)35S reaction, and it is shown that the proton energy released in this reaction varies linearly with the energy of the incoming neutron. The linearity of the response may enable CLYC to be used for fast-neutron spectroscopy with well defined spectral peaks. The response of CLYC to thermal neutrons and gamma rays is well known, and the material has potential for simultaneous thermal-neutron detection, fast-neutron spectroscopy, and gamma-ray spectroscopy.

Anomalous swelling in phospholipid bilayers is not coupled to the formation of a ripple phase.

Abstract: Aligned stacks of monomethyl and dimethyl dimyristoyl phosphatidylethanolamine (DMPE) lipid bilayers, like the much studied dimyristoyl PC (DMPC) bilayers, swell anomalously in a critical fashion as the temperature is decreased within the fluid phase towards the main transition temperature, T(M). Unlike DMPC bilayers, both monomethyl and dimethyl DMPE undergo transitions into a gel phase rather than a rippled phase below T(M). Although it is not fully understood why there is anomalous swelling, our present results should facilitate theory by showing that the formation of the phase below T(M) is not related to critical phenomena above T(M).

Transformation Temperatures and Welding Residual Stresses in Ferritic Steels

Abstract: Residual stress in the vicinity of a weld can have a large influence on structural integrity. Here the extent to which the martensite-start temperature of the weld filler metal can be adjusted to mitigate residual stress distributions in ferritic steel welds has been investigated. Three single-pass groove welds were deposited by manual-metal-arc welding on 12mm thick steel plates using filler metals designed to have different martensite-start temperatures. Their residual stress distributions were then characterised by neutron diffraction. It was found that a lower transformation temperature leads to a potentially less harmful stress distribution in and near the fusion zone. The experimental method is reported and the results are interpreted in the context of designing better welding consumables.Copyright © 2007 by ASME and National Research Council Canada

Autoinsertion of soluble oligomers of Alzheimer's Aβ(1-42) peptide into cholesterol-containing membranes is accompanied by relocation of the sterol towards the bilayer surface

Abstract: Soluble Alzheimer's Aβ oligomers autoinsert into neuronal cell membranes, contributing to the pathology of Alzheimer's Disease (AD), and elevated serum cholesterol is a risk factor for AD, but the reason is unknown. We investigated potential connections between these two observations at the membrane level by testing the hypothesis that Aβ(1–42) relocates membrane cholesterol. Oligomers of Aβ(1–42), but not the monomeric peptide, inserted into cholesterol-containing phosphatidylcholine monolayers with an anomalously low molecular insertion area, suggesting concurrent lipid rearrangement. Membrane neutron diffraction, including isomorphous replacement of specific lipid hydrogens with highly-scattering deuterium, showed that Aβ(1–42) insertion was accompanied by outward displacement of membrane cholesterol, towards the polar surfaces of the bilayer. Changes in the generalised polarisation of laurdan confirmed that the structural changes were associated with a functional alteration in membrane lipid order. Cholesterol is known to regulate membrane lipid order, and this can affect a wide range of membrane mechanisms, including intercellular signalling. Previously unrecognised Aβ-dependent rearrangement of the membrane sterol could have an important role in AD.