Showing papers by "Chalmers University of Technology published in 2008"

The worst-case execution-time problem—overview of methods and survey of tools

Abstract: The determination of upper bounds on execution times, commonly called worst-case execution times (WCETs), is a necessary step in the development and validation process for hard real-time systems. This problem is hard if the underlying processor architecture has components, such as caches, pipelines, branch prediction, and other speculative components. This article describes different approaches to this problem and surveys several commercially available tools1 and research prototypes.

Thermochemical biofuel production in hydrothermal media: A review of sub- and supercritical water technologies

Abstract: Hydrothermal technologies are broadly defined as chemical and physical transformations in high-temperature (200–600 °C), high-pressure (5–40 MPa) liquid or supercritical water. This thermochemical means of reforming biomass may have energetic advantages, since, when water is heated at high pressures a phase change to steam is avoided which avoids large enthalpic energy penalties. Biological chemicals undergo a range of reactions, including dehydration and decarboxylation reactions, which are influenced by the temperature, pressure, concentration, and presence of homogeneous or heterogeneous catalysts. Several biomass hydrothermal conversion processes are in development or demonstration. Liquefaction processes are generally lower temperature (200–400 °C) reactions which produce liquid products, often called “bio-oil” or “bio-crude”. Gasification processes generally take place at higher temperatures (400–700 °C) and can produce methane or hydrogen gases in high yields.

A unified view of ligand-protected gold clusters as superatom complexes

Abstract: Synthesis, characterization, and functionalization of self-assembled, ligand-stabilized gold nanoparticles are long-standing issues in the chemistry of nanomaterials. Factors driving the thermodynamic stability of well documented discrete sizes are largely unknown. Herein, we provide a unified view of principles that underlie the stability of particles protected by thiolate (SR) or phosphine and halide (PR3, X) ligands. The picture has emerged from analysis of large-scale density functional theory calculations of structurally characterized compounds, namely Au102(SR)44, Au39(PR3)14X6−, Au11(PR3)7X3, and Au13(PR3)10X23+, where X is either a halogen or a thiolate. Attributable to a compact, symmetric core and complete steric protection, each compound has a filled spherical electronic shell and a major energy gap to unoccupied states. Consequently, the exceptional stability is best described by a “noble-gas superatom” analogy. The explanatory power of this concept is shown by its application to many monomeric and oligomeric compounds of precisely known composition and structure, and its predictive power is indicated through suggestions offered for a series of anomalously stable cluster compositions which are still awaiting a precise structure determination.

Intraspecific ITS Variability in the Kingdom Fungi as Expressed in the International Sequence Databases and Its Implications for Molecular Species Identification

Abstract: The internal transcribed spacer (ITS) region of the nuclear ribosomal repeat unit is the most popular locus for species identification and subgeneric phylogenetic inference in sequence-based mycological research. The region is known to show certain variability even within species, although its intraspecific variability is often held to be limited and clearly separated from interspecific variability. The existence of such a divide between intra- and interspecific variability is implicitly assumed by automated approaches to species identification, but whether intraspecific variability indeed is negligible within the fungal kingdom remains contentious. The present study estimates the intraspecific ITS variability in all fungi presently available to the mycological community through the international sequence databases. Substantial differences were found within the kingdom, and the results are not easily correlated to the taxonomic affiliation or nutritional mode of the taxa considered. No single unifying yet stringent upper limit for intraspecific variability, such as the canonical 3% threshold, appears to be applicable with the desired outcome throughout the fungi. Our results caution against simplified approaches to automated ITS-based species delimitation and reiterate the need for taxonomic expertise in the translation of sequence data into species names.

Introduction to stochastic partial differential equations

Abstract: We introduce the Hilbert space-valued Wiener process and the corresponding stochastic integral of Ito type. This is then used together with semigroup theory to obtain existence and uniqueness of weak solutions of linear and semilinear stochastic evolution problems in Hilbert space. Finally, this abstract theory is applied to the linear heat and wave equations driven by additive noise.

On the structure of thiolate-protected Au25

Abstract: Density functional theory is used to explore the structure of Au25(RS)18. The preferred structure consists of an icosahedral Au13 core protected by 6 RS-Au-RS-Au-RS units. The enhanced stability of the structure as an anion is found to originate from closure of an eight-electron shell for delocalized Au(6s) electrons. The evaluated XRD pattern and optical spectra are in good agreement with experimental data.

Localized Surface Plasmon Resonances in Aluminum Nanodisks

Abstract: The plasmonic properties of arrays of supported Al nanodisks, fabricated by hole-mask colloidal lithography (HCL), are analyzed for the disk diameter range 61-492 nm at a constant disk height of 20 nm. Strong and well-defined (UV-vis-NIR) localized surface plasmon resonances are found and experimentally characterized with respect to spectral peak positions, peak widths, total cross sections, and radiative and nonradiative decay channels. Theoretically, the plasmon excitations are described by electrostatic spheroid theory. Very good qualitative and quantitative agreement between model and experiment is found for all these observables by assuming a nanoparticle embedded in a few nanometer thick homogeneous (native) aluminum oxide shell. Other addressed aspects are: (i) the role of the strong interband transition in Al metal, located at 1.5 eV, for the plasmonic excitations of Al nanoparticles, (ii) the role of the native oxide layer, and (iii) the possibility of using the plasmon excitation as an ultrasensitive, remote, real-time probe for studies of oxidation/corrosion kinetics in metal nanoparticle systems.

Cationic surface functionalization of cellulose nanocrystals

Abstract: The surface of cellulose nanocrystals, prepared by sulfuric acid hydrolysis of cotton, was rendered cationic through a reaction with epoxypropyltrimethylammonium chloride. The resultant nanocrystal suspensions were characterized by ζ-potential, conductometric titration and polarized light microscopy. Atomic force microscopy (AFM) showed no change in the size or shape of the nanocrystals, but the functionalization process reversed the surface charge and led to a reduction of the total surface charge density. These modifications led to stable aqueous suspensions of nanocrystalline cellulose with unexpected gelling and rheological properties. Shear birefringence was observed, but no liquid crystalline chiral nematic phase separation was detected.

Avoided crossing of rattler modes in thermoelectric materials

Abstract: Engineering of materials with specific physical properties has recently focused on the effect of nano-sized ‘guest domains’ in a ‘host matrix’ that enable tuning of electrical, mechanical, photo-optical or thermal properties. A low thermal conductivity is a prerequisite for obtaining effective thermoelectric materials, and the challenge is to limit the conduction of heat by phonons, without simultaneously reducing the charge transport. This is named the ‘phonon glass–electron crystal’ concept and may be realized in host–guest systems. The guest entities are believed to have independent oscillations, so-called rattlermodes,which scatter the acoustic phonons and reduce the thermal conductivity. We have investigated the phonon dispersion relation in the phonon glass–electron crystal material Ba8Ga16Ge30 using neutron triple-axis spectroscopy. The results disclose unambiguously the theoretically predicted avoided crossing of the rattler modes and the acoustic-phonon branches. The observed phonon lifetimes are longer than expected, and a new explanation for the low L is provided.

Liposomes: technologies and analytical applications.

Abstract: Liposomes are structurally and functionally some of the most versatile supramolecular assemblies in existence. Since the beginning of active research on lipid vesicles in 1965, the field has progressed enormously and applications are well established in several areas, such as drug and gene delivery. In the analytical sciences, liposomes serve a dual purpose: Either they are analytes, typically in quality-assessment procedures of liposome preparations, or they are functional components in a variety of new analytical systems. Liposome immunoassays, for example, benefit greatly from the amplification provided by encapsulated markers, and nanotube-interconnected liposome networks have emerged as ultrasmall-scale analytical devices. This review provides information about new developments in some of the most actively researched liposome-related topics.

Verification of Object-Oriented Software. the Key Approach

Abstract: The ultimate goal of program verification is not the theory behind the tools or the tools themselves, but the application of the theory and tools in the software engineering process. Our society relies on the correctness of a vast and growing amount of software. Improving the software engineering process is an important, long-term goal with many steps. Two of those steps are the KeY tool and this KeY book. The material is presented on an advanced level suitable for graduate courses and, of course, active researchers with an interest in verification. The underlying verification paradigm is deductive verification in an expressive program logic. The logic used for reasoning about programs is not a minimalist version suitable for theoretical investigations, but an industrial-strength version. The first-order part is equipped with a type system for modelling of object hierarchies, with underspecification, and with various built-in theories. The program logic covers full Java Card (plus a bit more such as multi-dimensional arrays, characters, and long integers). A lot of emphasis is thereby put on specification, including two widely-used object-oriented specification languages (OCL and JML) and even an interface to natural language generation. The generation of proof obligations from specified code is discussed at length. The book is rounded off by two substantial case studies that are included and presented in detail.

Temporary Primary Frequency Control Support by Variable Speed Wind Turbines— Potential and Applications

Abstract: This paper quantifies the capability of providing a short-term excess active power support of a commercial multi-megawatt variable speed wind turbine (VSWT) and generalizes the findings by considering different wind turbine (WT) physical parameters in a wider range from the example case. The paper also identifies some possible applications of it, in particular, in a hydro dominated system. To be able to quantify the system characteristic, a delay model of the studied hydro system is developed. Due to the fact that the initial power surge of a hydro turbine is opposite to that desired, the short-term extra active power support from a wind farm (WF) could be beneficial for a hydro dominated system in arresting the initial frequency fall, which corresponds to an improvement in the system temporary minimum frequency (TMF). The improvements in the TMF are calculated by using both the developed delay model and a detailed model, and the results show good agreement. It is shown that the WT under consideration can provide a 0.1 pu extra active power support for 10 s quite easily which is twice the Hydro-Quebec requirement.

Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments

Abstract: Pharmaceuticals are typically found in very low concentrations in the aquatic environment. Accordingly, environmental effects clearly assigned to residual drugs are consistent with high affinity interactions with conserved targets in affected wildlife species rather than with a general toxic effect. Thus, evolutionarily well-conserved targets in a given species are associated with an increased risk. In this study orthologs for 1318 human drug targets were predicted in 16 species of which several are relevant for ecotoxicity testing. The conservation of different functional categories of targets was also analyzed. Zebrafish had orthologs to 86% of the drug targets while only 61% were conserved in Daphnia and 35% in green alga. The predicted presence and absence of orthologs agrees well with published experimental data on the potential for specific drug target interaction in various species. Based on the conservation of targets we propose that aquatic environmental risk assessments for human drugs should always include comprehensive studies on aquatic vertebrates. Furthermore, individual targets, especially enzymes, are well conserved suggesting that tests on evolutionarily distant organisms would be highly relevant for certain drugs. We propose that the results can guide environmental risk assessments by improving the possibilities to identify species sensitive to certain types of pharmaceuticals or to other contaminants that act through well defined mechanisms of action. Moreover, we suggest that the results can be used to interpret the relevance of existing ecotoxicity data.

Photocatalytic Activity of Ag/ZnO Heterostructure Nanocatalyst: Correlation between Structure and Property

Abstract: Ag/ZnO heterostructure nanocatalysts with Ag content of 1 wt % are successfully prepared through three different simple methods, where chemical reduction and photolysis reaction are adopted to fabricate the heterostructure. The dispersity of Ag clusters and/or nanoparticles in Ag/ZnO nanocatalyst is investigated by EDX mapping and XPS techniques. The experimental results show that deposition-precipitation is an efficient method to synthesize Ag/ZnO nanocatalyst with highly dispersed Ag clusters and/or nanoparticles; the photocatalytic activity of Ag/ZnO photocatalysts mainly depends on the dispersity of metallic Ag in Ag/ZnO nanocatalyst; the higher the dispersity of metallic Ag in Ag/ZnO nanocatalyst is, the higher the photocatalytic activity of Ag/ZnO photocatalyst should be. In addition, it is also found that the dispersity of Ag/ZnO photocatalyst in the dye solution is another key factor for liquid-phase photocatalysis due to the UV-light utilizing efficiency. The higher the UV-light utilizing efficiency is, the higher the photocatalytic activity of Ag/ZnO heterostructure photocatalyst should be.

Protective Role of Reactive Astrocytes in Brain Ischemia

Abstract: Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due to the absence of suitable experimental models. Previously, we generated mice deficient in two intermediate filament (IF) proteins, glial fibrillary acidic protein (GFAP) and vimentin, whose upregulation is the hallmark of reactive astrocytes. GFAP(-/-)Vim(-/-) mice exhibit attenuated posttraumatic reactive gliosis, improved integration of neural grafts, and posttraumatic regeneration. Seven days after middle cerebral artery (MCA) transection, infarct volume was 210 to 350% higher in GFAP(-/-)Vim(-/-) than in wild-type (WT) mice; GFAP(-/-), Vim(-/-) and WT mice had the same infarct volume. Endothelin B receptor (ET(B)R) immunoreactivity was strong on cultured astrocytes and reactive astrocytes around infarct in WT mice but undetectable in GFAP(-/-)Vim(-/-) astrocytes. In WT astrocytes, ET(B)R colocalized extensively with bundles of IFs. GFAP(-/-)Vim(-/-) astrocytes showed attenuated endothelin-3-induced blockage of gap junctions. Total and glutamate transporter-1 (GLT-1)-mediated glutamate transport was lower in GFAP(-/-)Vim(-/-) than in WT mice. DNA array analysis and quantitative real-time PCR showed downregulation of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of tissue plasminogen activator. Thus, reactive astrocytes have a protective role in brain ischemia, and the absence of astrocyte IFs is linked to changes in glutamate transport, ET(B)R-mediated control of gap junctions, and PAI-1 expression.

An Even Sterner Review: Introducing Relative Prices into the Discounting Debate

Abstract: The Economics of Climate Change: The Stern Review has had a major influence on the policy discussion on climate change. One reason is that the report has raised the estimated cost of unmitigated climate damages by an order of magnitude compared to most earlier estimates, leading to a call for strong and urgent action on climate change. Not surprisingly, severe criticism has been levied against the report by authors who think that these results hinge mainly on the use of a discount rate that is too low. Here we discuss the Ramsey rule for the discount rates and its implications for the economics of climate change. While we find no strong objections to the discounting assumptions adopted in the Stern Review, our main point is that the conclusions reached in the review can be justified on other grounds than by using a low discount rate. We argue that nonmarket damages from climate change are probably underestimated and that future scarcities that will be induced by the changing composition of the economy and climate change should lead to rising relative prices for certain goods and services, raising the estimated damage of climate change and counteracting the effect of discounting. We build our analysis on earlier research (Hoel and Sterner 2007) that has shown that the Ramsey discounting formula is somewhat modified in a two-sector economy with differential growth rates. Most importantly, such a model is characterized by changing relative prices, something that has major implications for a correct valuation of future climate damages. We introduce these results into a slightly modified version of the DICE model (Nordhaus 1994) and find that taking relative prices into account can have as large an effect on economically warranted abatement levels as can a low discount rate.

A synthesis of atmospheric mercury depletion event chemistry in the atmosphere and snow

Abstract: It was discovered in 1995 that, during the spring time, unexpectedly low concentrations of gaseous elemental mercury (GEM) occurred in the Arctic air. This was surprising for a pollutant known to have a long residence time in the atmosphere; however conditions appeared to exist in the Arctic that promoted this depletion of mercury (Hg). This phenomenon is termed atmospheric mercury depletion events (AMDEs) and its discovery has revolutionized our understanding of the cycling of Hg in Polar Regions while stimulating a significant amount of research to understand its impact to this fragile ecosystem. Shortly after the discovery was made in Canada, AMDEs were confirmed to occur throughout the Arctic, sub-Artic and Antarctic coasts. It is now known that, through a series of photochemically initiated reactions involving halogens, GEM is converted to a more reactive species and is subsequently associated to particles in the air and/or deposited to the polar environment. AMDEs are a means by which Hg is transferred from the atmosphere to the environment that was previously unknown. In this article we review Hg research taken place in Polar Regions pertaining to AMDEs, the methods used to collect Hg in different environmental media, research results of the current understanding of AMDEs from field, laboratory and modeling work, how Hg cycles around the environment after AMDEs, gaps in our current knowledge and the future impacts that AMDEs may have on polar environments. The research presented has shown that while considerable improvements in methodology to measure Hg have been made but the main limitation remains knowing the speciation of Hg in the various media. The processes that drive AMDEs and how they occur are discussed. As well, the role that the snow pack and the sea ice play in the cycling of Hg is presented. It has been found that deposition of Hg from AMDEs occurs at marine coasts and not far inland and that a fraction of the deposited Hg does not remain in the same form in the snow. Kinetic studies undertaken have demonstrated that bromine is the major oxidant depleting Hg in the atmosphere. Modeling results demonstrate that there is a significant deposition of Hg to Polar Regions as a result of AMDEs. Models have also shown that Hg is readily transported to the Arctic from source regions, at times during springtime when this environment is actively transforming Hg from the atmosphere to the snow and ice surfaces. The presence of significant amounts of methyl Hg in snow in the Arctic surrounding AMDEs is important because this species is the link between the environment and impacts to wildlife and humans. Further, much work on methylation and demethylation processes has occurred but these processes are not yet fully understood. Recent changes in the climate and sea ice cover in Polar Regions are likely to have strong effects on the cycling of Hg in this environment; however more research is needed to understand Hg processes in order to formulate meaningful predictions of these changes.

‘Legitimation’ and ‘development of positive externalities’: two key processes in the formation phase of technological innovation systems

Abstract: Responding to the climate change challenge requires a massive development and diffusion of carbon neutral technologies and, thus, emergence and growth of new socio-technical systems. This paper contributes to an improved understanding of the formative phase of new technological innovation systems (TIS) by outlining a framework for analysing TIS dynamics in terms of structural growth and key innovation-related processes (“functions”) and by discussing two of these functions at some depth: “legitimation” and “development of positive externalities”. Empirical examples are provided from case studies on renewable energy technologies. We highlight the problematic role of technology assessment studies in shaping legitimacy and the importance of early market formation for the emergence of “packs of entrepreneurs” that may contribute to legitimation, and discuss how exploitation of overlaps between different TISs may create positive externalities, opening up for a powerful “bottom-up” process of system growth. Ass...

Creativity in entrepreneurship education

Abstract: Purpose - The purpose of this paper is to use social cognitive theory to investigate entrepreneurial intent among participants in graduate entrepreneurship programs. Specifically, the authors test whether students' creative potential is related to their intention to engage in entrepreneurship. Design/methodology/approach - Theoretically derived hypotheses are tested using multiple and ordinal regression analyses. Findings - High scores on a creativity test and prior entrepreneurial experiences are positively associated with entrepreneurial intentions, whereas perception of risks has a negative influence. Research limitations/implications - The authors' theoretical predictors of entrepreneurial intention received strong support, indicating that creativity should be considered in models of entrepreneurial intentions. However, the use of intentions as dependent variable has its own weaknesses in that it may not distinguish between "dreamers" and "doers". Practical implications - The findings indicate that exercises in creativity can be used to raise the entrepreneurial intentions of students in entrepreneurship education. Heterogeneity in creative styles among students also points to the problems of a "one-size-fits-all" approach to entrepreneurship education. Originality/value - The paper is the first to investigate the importance of creativity in entrepreneurship education and theoretical models of entrepreneurial intentions.

The use of ilmenite as an oxygen carrier in chemical-looping combustion

Abstract: The feasibility of using ilmenite as oxygen carrier in chemical-looping combustion has been investigated. Itwas found that ilmenite is an attractive and inexpensive oxygen carrier for chemical-looping combustion.Alaboratory fluidizedbed reactor system, simulating chemical-looping combustion by exposing the sample to alternating reducing and oxidizing conditions,was used to investigate the reactivity. During the reducing phase, 15 g of ilmenite with a particle size of 125–180μm was exposed to a flow of 450mLn/min of either methane or syngas (50% CO, 50% H2) and during the oxidizing phase to a flow of 1000mLn/min of 5% O2 in nitrogen. The ilmenite particles showed no decrease in reactivity in the laboratory experiments after 37 cycles of oxidation and reduction. Equilibrium calculations indicate that the reduced ilmenite is in the form FeTiO3 and the oxidized carrier is in the form Fe2TiO5 +TiO2. The theoretical oxygen transfer capacity between these oxidation states is 5%. The same oxygen transfer capacity was obtained in the laboratory experiments with syngas. Equilibrium calculations indicate that ilmenite should be able to give high conversion of the gases with the equilibrium ratios CO/(CO2 + CO) and H2/(H2O+H2) of 0.0006 and 0.0004, respectively. Laboratory experiments suggest a similar ratio for CO. The equilibrium calculations give a reaction enthalpy of the overall oxidation that is 11% higher than for the oxidation of methane per kmol of oxygen. Thus, the reduction from Fe2TiO5 +TiO2 to FeTiO3 with methane is endothermic, but less endothermic compared to NiO/Ni and Fe2O3/Fe3O4, and almost similar to Mn3O4/MnO.

MPC-based yaw and lateral stabilisation via active front steering and braking

Abstract: In this paper we propose a path following Model Predictive Control-based (MPC) scheme utilizing steering and braking. The control objective is to track a desired path for obstacle avoidance maneuver, by a combined use of braking and steering. The proposed control scheme relies on the Nonlinear MPC (NMPC) formulation we used in [1] and [2]. In this work, the NMPC formulation will be used in order to derive two different approaches. The first relies on a full tenth order vehicle model and has high computational burden. The second approach is based on a simplified bicycle model and has a lower computational complexity compared to the first. The effectiveness of the proposed approaches is demonstrated through simulations and experiments.

Triplet supercurrents in clean and disordered half-metallic ferromagnets

Abstract: Interfaces between materials with differently ordered phases present unique opportunities to study fundamental problems in physics. One example is the interface between a singlet superconductor and a half-metallic ferromagnet, where Cooper pairing occurs between electrons with opposite spin on the superconducting side, whereas the other exhibits 100% spin polarization. The recent surprising observation of a supercurrent through half-metallic CrO2 therefore requires a mechanism for conversion between unpolarized and completely spin-polarized supercurrents. Here, we suggest a conversion mechanism based on electron spin precession together with triplet-pair rotation at interfaces with broken spin-rotation symmetry. In the diffusive limit (short mean free path), the triplet supercurrent is dominated by inter-related odd-frequency s-wave and even-frequency p-wave pairs. In the crossover to the ballistic limit, further symmetry components become relevant. The interface region exhibits a superconducting state of mixed-spin pairs with highly unusual symmetry properties that open up new perspectives for exotic Josephson devices.

Learning outcomes for sustainable development in higher education

Abstract: Purpose - This paper sets out to discuss the commonalities that can be found in learning outcomes (LOs) for education for sustainable development in the context of the Tbilisi and Barcelona declarations The commonalities include systemic or holistic thinking, the integration of different perspectives, skills such as critical thinking, change agent abilities and communication, and finally different attitudes and values Design/methodology/approach - An analysis of LOs that are proposed in the Tbilisi and Barcelona declarations is conducted, showing specific issues for the commonalities presented Examples of LOs from Instituto TecnolA³gico y de Estudios Superiores de Monterrey (ITESM) in Mexico, as well as various associations from the USA is shown A brief discussion is done on the means to achieve these LOs and learning evaluation Findings - In the example sets of LOs shown, the commonalities presented in the paper's first section appear in the LOs proposed by the institutions Based on current knowledge and perception, sustainability is properly addressed in the examples Practical implications - The paper can be used to foster a wider discussion and analysis of LOs for sustainability education, also further work on teachers' capacity building for sustainability, as well as the assessment needed for future professionals in higher education institutions Originality/value - The paper presents the onset of discussing and comparing commonalities among higher education institutions regarding sustainability LOs

The dynamics of sustainable innovation journeys

Abstract: Since the 1970s, environmental problems have risen on the political agenda. Many environmental problems (such as water pollution, local air pollution, acid rain) have since been solved or substanti...

High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours.

Abstract: ALK (anaplastic lymphoma kinase) is oncogenic in several tumours and has recently been identified as a predisposition gene for familial NB (neuroblastoma) harbouring mutations in the TKD (tyrosine kinase domain). We have analysed a large set of sporadic human NB primary tumours of all clinical stages for chromosomal re-arrangements using a CGH (comparative genomic hybridization) array (n=108) and mutations of the ALK gene (n=90), and expression of ALK and related genes (n=19). ALK amplification or in-gene re-arrangements were found in 5% of NB tumours and mutations were found in 11%, including two novel not previously published mutations in the TKD, c.3733T>A and c.3735C>A. DNA mutations in the TKD and gene amplifications were only found in advanced large primary tumours or metastatic tumours, and correlated with the expression levels of ALK and downstream genes as well as other unfavourable features, and poor outcome. The results of the present study support that the ALK protein contributes to NB oncogenesis providing a highly interesting putative therapeutic target in a subset of unfavourable NB tumours.

Voltage and Reactive Power Control in Systems With Synchronous Machine-Based Distributed Generation

Abstract: This paper investigates voltage and reactive power control in distribution systems and how the presence of synchronous machine-based distributed generation (DG) affects the control. A proper coordination among the onload tap changer (OLTC), substation switched capacitors and feeder-switched capacitors in order to obtain optimum voltage and reactive power control is proposed. It is assumed that there is no communication link between the OLTC and the capacitors, a normal case in distribution system operation these days. The results indicate that the proposed method decreases the number of OLTC operations, losses, and voltage fluctuations in distribution systems, with and without DG present. The power-flow reversal due to the DG is shown not to interfere with the effectiveness of the OLTC operation. Further, it is also shown that as long as the available capacitors are enough to compensate the reactive power demand, the DG operation mode does not give a significant effect to the distribution system losses. However, DG operating at a constant voltage is beneficial for a significant reduction of OLTC operation and voltage fluctuation in the distribution system.