Institution
Chaminade University of Honolulu
Education•Honolulu, Hawaii, United States•
About: Chaminade University of Honolulu is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Experiential learning. The organization has 164 authors who have published 223 publications receiving 5381 citations.
Papers published on a yearly basis
Papers
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TL;DR: Reversible coupling of the TRPA1 channels with O2-dependent protein translocation allows astrocytes to act as acute hypoxia sensors in the medullary respiratory center.
26 citations
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TL;DR: The knowledge to date pertinent to the role of DAMPs and PRRs in fetal membrane weakening is summarized and the clinical potential brought by a better understanding of these pathways by pathway manipulation strategies is discussed.
Abstract: The idea that cellular stress (including that precipitated by stretch), plays a significant role in the mechanisms initiating parturition, has gained considerable traction over the last decade. One key consequence of this cellular stress is the increased production of Danger Associated Molecular Patterns (DAMPs). This diverse family of molecules are known to initiate inflammation through their interaction with Pattern Recognition Receptors (PRRs) including, Toll-like receptors (TLRs). TLRs are the key innate immune system surveillance receptors that detect Pathogen Associated Molecular Patterns (PAMPs) during bacterial and viral infection. This is also seen during Chorioamnionitis. The activation of TLR commonly results in the activation of the pro-inflammatory transcription factor Nuclear Factor Kappa-B (NF-kB) and the downstream production of pro-inflammatory cytokines. It is thought that in the human fetal membranes both DAMPs and PAMPs are able, perhaps via their interaction with PRRs and the induction of their downstream inflammatory cascades, to lead to both tissue remodeling and weakening. Due to the high incidence of infection-driven Pre-Term Birth (PTB), including those that have preterm Premature Rupture of the Membranes (pPROM), the role of TLR in fetal membranes with Chorioamnionitis has been the subject of considerable study. Most of the work in this field has focused on the effect of PAMPs on whole pieces of fetal membrane and the resultant inflammatory cascade. This is important to understand, in order to develop novel prevention, detection, and therapeutic approaches, which aim to reduce the high number of mothers suffering from infection driven PTB, including those with pPROM. Studying the role of sterile inflammation driven by these endogenous ligands (DAMPs) activating PRRs system in the mesenchymal and epithelial cells in the amnion is important. These cells are key for the maintenance of the integrity and strength of the human fetal membranes. This review aims to (1) summarize the knowledge to date pertinent to the role of DAMPs and PRRs in fetal membrane weakening and (2) discuss the clinical potential brought by a better understanding of these pathways by pathway manipulation strategies.
26 citations
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TL;DR: This experiment conducted an experiment to characterize microbiological and chemical properties of decomposing swine carcasses on the island of Oahu, Hawaii, USA, during June 2013, and recommends that culturable postmortem and larval mass microbiology and chemistry be investigated in more detail.
25 citations
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TL;DR: The challenges and realities of having multi-generational workforce of the past 20 years or so is the focus of a special issue of the Journal of Intergenerational Relationships (JIR).
Abstract: The multi-generational workforce of the past 20 years or so is the focus of this special issue of the Journal of Intergenerational Relationships (JIR). The challenges and realities of having multip...
24 citations
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TL;DR: By augmenting VEGFR2 expression in the placental amnion, PBEF primes the tissue for a VEGF-mediated increase in permeability, which may have important implications in amniotic fluid volume control throughout gestation.
24 citations
Authors
Showing all 165 results
Name | H-index | Papers | Citations |
---|---|---|---|
Helen Turner | 32 | 126 | 4487 |
David O. Carter | 28 | 70 | 2978 |
Alexander J. Stokes | 22 | 45 | 3059 |
Katelynn Perrault | 18 | 40 | 810 |
David Gonçalves | 16 | 60 | 770 |
Jace Hargis | 16 | 66 | 714 |
Michael R. Dohm | 14 | 18 | 1145 |
George S. Vozikis | 13 | 33 | 602 |
Henry G. Trapido-Rosenthal | 13 | 18 | 801 |
Christopher A. McNally | 12 | 19 | 496 |
Lori M. N. Shimoda | 12 | 21 | 587 |
Richard M. Alvey | 11 | 11 | 647 |
Laura Tipton | 10 | 18 | 605 |
M. Lee Goff | 9 | 11 | 432 |
Paulo S. Martins | 8 | 66 | 176 |