Chaminade University of Honolulu

About: Chaminade University of Honolulu is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Experiential learning. The organization has 164 authors who have published 223 publications receiving 5381 citations.

Using microbiome tools for estimating the postmortem interval

Abstract: Estimating the postmortem interval (PMI) of human remains is important in criminal investigations. Microbes play an important role in the process of decomposition and can provide clues about the time elapsed since death. Host-associated and environmental microbial communities have been shown to undergo succession in a predictable, clock-like manner during decomposition. High-throughput DNA sequencing can be used to inexpensively and rapidly track these microbial community shifts, and machine learning techniques can use these data to develop predictive models. In this chapter, we discuss the development of a microbial clock for estimating PMI, as well as remaining knowledge gaps and hurdles to technology adoption.

Developing Polyamine-Based Peptide Amphiphiles with Tunable Morphology and Physicochemical Properties

Abstract: The ability to tune supramolecular properties such as size, morphology, or metabolic stability is of paramount importance in the field of supramolecular chemistry. Peptide amphiphiles (PAs) are a family of functional self-assembling biomaterials that have garnered widespread attention due to their broad applicability in medicine. PAs are generally comprised of an amino acid sequence connected to lipid tail(s) allowing them to self-assemble into supramolecular structures with diverse morphologies. Herein, this study describes the synthesis of a new class of polyamine-based "hybrid" PAs (PPAs) as novel self-assembling systems. The described molecules possess diverse polyamine head groups with the goal of tuning physicochemical properties. The findings indicate that small changes in the polyamine head groups result in altered PPA morphologies (nanofibers, micelles, nanoworms). The PPAs present a wide range of physicochemical characteristics, show superior resistance to aggregation, a diverse metabolic profile, and varied assembling kinetics. Most of the PPAs do not show toxicity in the human cells lines evaluated. The PPAs described herein hold promising potential as a safe and nontoxic option for drug delivery, targeting, and tissue engineering applications.

How to Survive a Cyber Pearl Harbor

Abstract: An examination of parallels between the "Day of Infamy" and a major cyberattack reveals lessons for organizations about vulnerability, the nature of survival, and the tenets of protection that can help boost resilience against hackers and other cyberthreats.

Identifying Fourth Graders' Understanding of Rational Number Representations: A Mixed Methods Approach.

Abstract: This study examined average-, high- and top-performing US fourth graders' rational number problem solving and their understanding of rational number representations. In phase one, all students completed a written test designed to tap their skills for multiplication, division and rational number word-problem solving. In phase two, a subset of students sorted cards that showed part-whole, ratio, quotient, measure, and operator perspectives of rational number representations. Each perspective was shown in numerical notational, word-problem, and visual formats. The results indicated that top-performing students scored significantly higher in problem solving and showed more effectively linked rational number representations than the other groups. The results imply that successful rational number problem solving is intertwined with representational knowledge for a wide range of rational numbers and that the bulk of US students do not possess effective skills for working with rational number representations.

Genetic patterns in Montipora capitata across an environmental mosaic in Kaneohe Bay

Abstract: Spatial genetic structure (SGS) is important to a populations ability to adapt to environmental change. For species that reproduce both sexually and asexually, the relative contribution of each reproductive mode has important ecological and evolutionary implications because asexual reproduction can have a strong effect on SGS. Reef building corals reproduce sexually, but many species also propagate asexually under certain conditions. In order to understand SGS and the relative importance of reproductive mode across environmental gradients, we evaluated genetic relatedness in almost 600 colonies of Montipora capitata across 30 environmentally characterized sites in K[a]neohe Bay, Oahu, Hawaii using low-depth restriction digest associated sequencing. Clonal colonies were relatively rare overall but influenced SGS. Clones were located significantly closer to one another spatially than average colonies and were more frequent on sites where wave energy was relatively high, suggesting a strong role of mechanical breakage in their formation. Excluding clones, we found no evidence of isolation by distance within sites or across the bay. Several environmental characteristics were significant predictors of the underlying genetic variation (including degree heating weeks, time spent above 30{degrees}C, depth, sedimentation rate and wave height); however, they only explained 5% of this genetic variation. Our results show that colony fragmentation contributes to the ecology of M. capitata at local scales and that genetic diversity is maintained despite strong environmental gradients in a highly impacted ecosystem, suggesting potential for broad adaptation or acclimatization in this population.