Institution
Chandka Medical College
Education•Larkana, Pakistan•
About: Chandka Medical College is a education organization based out in Larkana, Pakistan. It is known for research contribution in the topics: Population & Outpatient clinic. The organization has 106 authors who have published 108 publications receiving 1170 citations.
Papers published on a yearly basis
Papers
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TL;DR: The frequency of cytogenetic abnormalities in AML and response to induction chemotherapy was low when compared with international data possibly due to the small sample size, however, there was a clear difference in CR rates between favourable and unfavourable risk groups.
Abstract: Results: A total of 56 patients were enrolled, 4 were excluded due to inadequate cytogenetic analysis and the remaining patients entered the study protocol. There were 32 males and 20 females with mean age of 31.3 years (range 9 months to 73 years). Thirty-five (67.3%) patients had normal karyotype while 17 (32.7%) were found to have cytogenetic abnormalities. Eleven patients did not receive treatment at our hospital. Half of the (51.2%) patients out of remaining 41 achieved complete remission on bone marrow examination after receiving induction chemotherapy. In favourable risk group 3/3 (100%) achieved complete remission (CR) while 15/32 (46.9%) in intermediate risk group and 3/6 (50%) in unfavourable risk group. There was low CR rate in patients with high white cell counts. Conclusion: The frequency of cytogenetic abnormalities in AML and response to induction chemotherapy was low when compared with international data possibly due to the small sample size. However, there was a clear difference in CR rates between favourable and unfavourable risk groups (JPMA 56:9;2006).
8 citations
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TL;DR: This case report describes a young lady who presented with complaints of neck pain and weakness of all four limbs for the last eight months and underwent extended cervical laminectomy from C-3 to C-7 level, confirming a case of ganglioneuroma.
Abstract: This case report describes a young lady who presented with complaints of neck pain and weakness of all four limbs for the last eight months. Magnetic Resonance Imaging (MRI) scan of cervical spine revealed dumbbell shaped extramedullary lesion at C-3 and C-4 level extending outside through neural foramen of C-3. She underwent extended cervical laminectomy from C-3 to C-7 level. Postoperatively power was gradually regained in all four limbs. Histopathology confirmed a case of ganglioneuroma.
7 citations
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TL;DR: The incidence of foot amputation in diabetic patients is high and crucial risk factors include male gender, smoking, hyperlipidemia, hypertension, cardiac history, and the coexistence of diabetic nephropathy and retinopathy.
Abstract: Introduction
The major grave outcome of diabetic complications is the amputation of lower limb extremities. Recurrent foot infections, trauma, ischemia, and peripheral neuropathy play a crucial role in predicting foot amputation. The aim of this study is to identify the risk factors of diabetic foot amputations in Pakistani patients.
Methods
Patients admitted with diabetic foot-related complications were followed throughout their hospital stay. Their sociodemographic and disease-related characteristics were recorded. Patients who were advised foot amputation were taken as group A, and patients who were managed conservatively were termed as group B. Their characteristics were then compared.
Results
Out of 226 study participants, there were 51 (22.5%) patients in group A who were advised foot amputation. There were more men in group A as compared to group B (72.5% vs. 30.8%; p<0.00001). Group A also had a longer duration of diabetes (15.23 ± 8.52 years vs. 11.98 ± 9.69; p=0.03). Group B included more patients taking insulin therapy (44.5% vs. 37.3%; p=0.002). All three risk factors of atherosclerosis - smoking, hyperlipidemia, and hypertension - were significantly associated with group A (p≤0.05). This coexistence of diabetic nephropathy and retinopathy were more common in group A (p≤0.05).
Conclusion
The incidence of foot amputation in diabetic patients is high. Crucial risk factors include male gender, smoking, hyperlipidemia, hypertension, cardiac history, and the coexistence of diabetic nephropathy and retinopathy.
7 citations
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TL;DR: This is the first case report in Pakistan on TRb with suprasellar mass, which is a rare combination of unilateral or bilateral retinoblastoma with an ectopic midline intracranial neuroblastic neoplasm (primitive neuroectodermal tumour) usually in the area of pineal gland or sellar region.
Abstract: Trilateral retinoblastoma (TRb) is a rare combination of unilateral or bilateral retinoblastoma with an ectopic midline intracranial neuroblastic neoplasm (primitive neuroectodermal tumour) usually in the area of pineal gland or sellar region. TRb can occur with both familial and sporadic forms of retinoblastoma. An occurrence of this rare tumour in a 12-year-old boy who had unilateral retinoblastoma in association with ectopic suprasellar primitive neuroectodermal tumour (PNET) is reported here. To the best of our knowledge, this is the first case report in Pakistan on TRb with suprasellar mass.
7 citations
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TL;DR: In the present study, two consanguineous families, A and B, in which HJMD occurs, have been identified.
Abstract: Human juvenile macular dystrophy (HJMD) results from a rare autosomal recessive genetic anomaly, manifesting with hypotrichosis and gradual loss of vision due to progressive macular degeneration. Variants in the CDH3 gene, encoding a trans-membrane glycoprotein P-cadherin, have been reported to result in HJMD [1] and its closely associated form, ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM) [2].In the present study, two consanguineous families, A and B (figures 1A, B), in which HJMD [...]
6 citations
Authors
Showing all 106 results
Name | H-index | Papers | Citations |
---|---|---|---|
Raj G. Kumar | 16 | 55 | 928 |
Dost Muhammad | 13 | 43 | 449 |
Bader Faiyaz Zuberi | 12 | 61 | 1056 |
Abdul Manan Bhutto | 9 | 22 | 332 |
Farooq Rahman Soomro | 8 | 15 | 213 |
Rosmaliza Muhammad | 8 | 43 | 247 |
Jawaid Akbar Sial | 6 | 37 | 150 |
Chandur Bhan | 4 | 4 | 51 |
Javed Hussain Baloch | 4 | 4 | 85 |
Hakim Ali Abro | 4 | 7 | 70 |
Sirajuddin Soomro | 3 | 7 | 30 |
Partab Rai | 3 | 6 | 29 |
Afsar Ali Bhutto | 3 | 4 | 37 |
Munawar Hussain Soomro | 3 | 13 | 82 |
Quratul-ain Soomro | 3 | 5 | 39 |