Institution
Charité
Healthcare•Berlin, Germany•
About: Charité is a healthcare organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 30624 authors who have published 64507 publications receiving 2437322 citations. The organization is also known as: Charite & Charité – University Medicine Berlin.
Topics: Population, Transplantation, Immune system, Heart failure, Cancer
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Golimumab was effective and well tolerated in a large cohort of patients with ankylosing spondylitis during a 24-week study period.
Abstract: Objective To evaluate the efficacy and safety of golimumab in patients with ankylosing spondylitis (AS) in the GO-RAISE study. Methods Patients with active AS, a Bath AS Disease Activity Index (BASDAI) score > or =4, and a back pain score of > or =4 were randomly assigned in a 1.8:1.8:1 ratio to receive subcutaneous injections of golimumab (50 mg or 100 mg) or placebo every 4 weeks. The primary end point was the proportion of patients with at least 20% improvement in the ASsessment in AS (ASAS20) criteria at week 14. Results At randomization, 138, 140, and 78 patients were assigned to the 50-mg, 100-mg, and placebo groups, respectively. After 14 weeks, 59.4%, 60.0%, and 21.8% of patients, respectively, were ASAS20 responders (P or =1 adverse event, and 5.4% and 6.5% of patients, respectively, had > or =1 serious adverse event. Eight golimumab-treated patients and 1 placebo-treated patient had markedly abnormal liver enzyme values (> or =100% increase from baseline and a value >150 IU/liter), which were transient. Conclusion Golimumab was effective and well tolerated in a large cohort of patients with AS during a 24-week study period.
523 citations
••
TL;DR: Irinotecan as second-line chemotherapy significantly prolongs overall survival compared to BSC in the studied pts and can now be considered as a proven treatment option for metastatic or locally advanced gastric cancer.
523 citations
••
Paris Descartes University1, Cedars-Sinai Medical Center2, University of Alberta3, Johns Hopkins University4, University of Paris5, Autonomous University of Barcelona6, Westmead Hospital7, Harvard University8, University of Texas Medical Branch9, Yeshiva University10, University of Cologne11, Mayo Clinic12, University of Maryland, Baltimore13, Charité14, Leiden University15, University of Manitoba16, Washington University in St. Louis17, NewYork–Presbyterian Hospital18, University of North Carolina at Chapel Hill19, University of Pittsburgh20, University of California, Los Angeles21, Hammersmith Hospital22, Cornell University23, Northwestern University24
TL;DR: Improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification are included.
522 citations
••
TL;DR: The study shows a benefit of SB in phakic eyes with respect to BCVA improvement, and based on a better anatomical outcome, recommends PPV in these patients.
522 citations
••
TL;DR: A new measure (phase-slope index) to estimate the direction of information flux in multivariate time series is proposed that is insensitive to mixtures of independent sources, gives meaningful results even if the phase spectrum is not linear, and properly weights contributions from different frequencies.
Abstract: We propose a new measure (phase-slope index) to estimate the direction of information flux in multivariate time series. This measure (a) is insensitive to mixtures of independent sources, (b) gives meaningful results even if the phase spectrum is not linear, and (c) properly weights contributions from different frequencies. These properties are shown in extended simulations and contrasted to Granger causality which yields highly significant false detections for mixtures of independent sources. An application to electroencephalography data (eyes-closed condition) reveals a clear front-to-back information flow.
521 citations
Authors
Showing all 30787 results
Name | H-index | Papers | Citations |
---|---|---|---|
JoAnn E. Manson | 270 | 1819 | 258509 |
Yi Chen | 217 | 4342 | 293080 |
David J. Hunter | 213 | 1836 | 207050 |
Raymond J. Dolan | 196 | 919 | 138540 |
John P. A. Ioannidis | 185 | 1311 | 193612 |
Stefan Schreiber | 178 | 1233 | 138528 |
Kenneth C. Anderson | 178 | 1138 | 126072 |
Eric J. Nestler | 178 | 748 | 116947 |
Klaus Rajewsky | 154 | 504 | 88793 |
Charles B. Nemeroff | 149 | 979 | 90426 |
Andreas Pfeiffer | 149 | 1756 | 131080 |
Rinaldo Bellomo | 147 | 1714 | 120052 |
Jean Bousquet | 145 | 1288 | 96769 |
Christopher Hill | 144 | 1562 | 128098 |
Holger J. Schünemann | 141 | 810 | 113169 |