Institution
Charité
Healthcare•Berlin, Germany•
About: Charité is a healthcare organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 30624 authors who have published 64507 publications receiving 2437322 citations. The organization is also known as: Charite & Charité – University Medicine Berlin.
Topics: Population, Transplantation, Medicine, Cancer, Immune system
Papers published on a yearly basis
Papers
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TL;DR: Stem cells from a donor who was homozygous for CCR5 delta32 were transplanted in a patient with acute myeloid leukemia and HIV-1 infection and the patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy.
Abstract: Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.
1,657 citations
Mohammad H. Forouzanfar1, Lily Alexander1, H. Ross Anderson2, Victoria F Bachman1 +718 more•Institutions (295)
TL;DR: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) as mentioned in this paper provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.
1,656 citations
TL;DR: This work presents a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and shows that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods.
Abstract: Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
1,620 citations
Christopher J L Murray1, Ryan M Barber, Kyle J Foreman2, Ayse Abbasoglu Ozgoren +608 more•Institutions (251)
TL;DR: Patterns of the epidemiological transition with a composite indicator of sociodemographic status, which was constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population, were quantified.
1,609 citations
TL;DR: In this paper, the authors developed guidelines for reporting reliability and agreement studies in interrater and intra-arater reliability and agreements, and proposed 15 issues that should be addressed when reporting such studies.
1,605 citations
Authors
Showing all 30787 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| JoAnn E. Manson | 270 | 1819 | 258509 |
| Yi Chen | 217 | 4342 | 293080 |
| David J. Hunter | 213 | 1836 | 207050 |
| Raymond J. Dolan | 196 | 919 | 138540 |
| John P. A. Ioannidis | 185 | 1311 | 193612 |
| Stefan Schreiber | 178 | 1233 | 138528 |
| Kenneth C. Anderson | 178 | 1138 | 126072 |
| Eric J. Nestler | 178 | 748 | 116947 |
| Klaus Rajewsky | 154 | 504 | 88793 |
| Charles B. Nemeroff | 149 | 979 | 90426 |
| Andreas Pfeiffer | 149 | 1756 | 131080 |
| Rinaldo Bellomo | 147 | 1714 | 120052 |
| Jean Bousquet | 145 | 1288 | 96769 |
| Christopher Hill | 144 | 1562 | 128098 |
| Holger J. Schünemann | 141 | 810 | 113169 |