Institution
Charles University in Prague
Education•Prague, Czechia•
About: Charles University in Prague is a education organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 32392 authors who have published 74435 publications receiving 1804208 citations.
Topics: Population, Large Hadron Collider, Czech, Magnetization, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: The halfspace itrange itreporting problem, given a finite set P of points in R d, can be solved substantially more efficiently that the more general simplex range searching problem.
Abstract: We consider the halfspace itrange itreporting problem: given a finite set P of points in R d, preprocess it so that given a query halfspace γ, the points of P ∩ γ can be reported efficiently. We show that with almost linear storage, this problem can be solved substantially more efficiently that the more general simplex range searching problem. We give a data structure for halfspace range reporting in dimensions d ⩾ 4 with O(n log log n) space, O(n log n) deterministic preprocessing time and O(n 1 − 1 ⌊ d 2 ⌋ (logn) c + k) query time, where c = c(d) is a constant and k = |P ∩ γ| (efficient solutions were known for d = 2, 3). For the halfspace emptiness problem, where we only want to know whether P ∩ γ = O, we can achieve query time O(n 1 − 1 ⌊ d 2 ⌋ 2 c'log ∗ n ) with a linear space and O(n1 + δ) preprocessing (c' = c'(d) is a constant and γ > 0 is arbitrarily small but fixed).
292 citations
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University of Liège1, Van Andel Institute2, University of L'Aquila3, University of Brasília4, University of Buenos Aires5, French Institute of Health and Medical Research6, Sapienza University of Rome7, Erasmus University Rotterdam8, University of Turin9, Austral University10, University of Naples Federico II11, University of Perugia12, Charles University in Prague13, Federal University of Rio de Janeiro14, Centre national de la recherche scientifique15
TL;DR: AIP mutations, of which nine new mutations have been described here, occur in approximately 15% of FIPA families, and although pituitary tumors occurring in association with AIP mutations are predominantly somatotropinomas, other tumor types are also seen.
Abstract: Context An association between germline aryl hydrocarbon receptor-interacting protein (AIP) gene mutations and pituitary adenomas was recently shown. Objective The objective of the study was to assess the frequency of AIP gene mutations in a large cohort of patients with familial isolated pituitary adenoma (FIPA). Design This was a multicenter, international, collaborative study. Setting The study was conducted in 34 university endocrinology and genetics departments in nine countries. Patients Affected members from each FIPA family were studied. Relatives of patients with AIP mutations underwent AIP sequence analysis. Main outcome measures Presence/absence and description of AIP gene mutations were the main outcome measures. Intervention There was no intervention. Results Seventy-three FIPA families were identified, with 156 patients with pituitary adenomas; the FIPA cohort was evenly divided between families with homogeneous and heterogeneous tumor expression. Eleven FIPA families had 10 germline AIP mutations. Nine mutations, R16H, G47_R54del, Q142X, E174frameshift, Q217X, Q239X, K241E, R271W, and Q285frameshift, have not been described previously. Tumors were significantly larger (P = 0.0005) and diagnosed at a younger age (P = 0.0006) in AIP mutation-positive vs. mutation-negative subjects. Somatotropinomas predominated among FIPA families with AIP mutations, but mixed GH/prolactin-secreting tumors, prolactinomas, and nonsecreting adenomas were also noted. Approximately 85% of the FIPA cohort and 50% of those with familial somatotropinomas were negative for AIP mutations. Conclusions AIP mutations, of which nine new mutations have been described here, occur in approximately 15% of FIPA families. Although pituitary tumors occurring in association with AIP mutations are predominantly somatotropinomas, other tumor types are also seen. Further study of the impact of AIP mutations on protein expression and activity is necessary to elucidate their role in pituitary tumorigenesis in FIPA.
292 citations
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Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam +2333 more•Institutions (195)
TL;DR: In this paper, the authors acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies:======BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,======And FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS======(Colombia); MSES and CSF (Croatia); RPF (
Abstract: we acknowledge the enduring support for the construction and
operation of the LHC and the CMS detector provided by the following funding agencies:
BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES and CSF (Croatia); RPF (Cyprus); SENESCYT (Ecuador);
MoER, ERC IUT and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland);
CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece);
OTKA and NIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN
(Italy); MSIP and NRF (Republic of Korea); LAS (Lithuania); MOE and UM (Malaysia);
BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MBIE (New
Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Dubna);
MON, RosAtom, RAS and RFBR (Russia); MESTD (Serbia); SEIDI and CPAN (Spain);
Swiss Funding Agencies (Switzerland); MST (Taipei); ThEPCenter, IPST, STAR and
NSTDA (Thailand); TUBITAK and TAEK (Turkey); NASU and SFFR (Ukraine); STFC
(United Kingdom); DOE and NSF (U.S.A.).
292 citations
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TL;DR: In this paper, the authors collected 1,205 estimates of spillovers and examined which factors influence spillover magnitude, concluding that horizontal productivity spillovers are on average zero, but that their sign and magnitude depend systematically on the characteristics of the domestic economy and foreign investors.
291 citations
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TL;DR: The reduction of skeletal muscle glycogen after exercise allows a healthy storage of carbohydrates after meals and prevents development of type 2 diabetes.
Abstract: Glycogen is the storage form of carbohydrates in mammals. In humans the majority of glycogen is stored in skeletal muscles (~500 g) and the liver (~100 g). Food is supplied in larger meals, but the blood glucose concentration has to be kept within narrow limits to survive and stay healthy. Therefore, the body has to cope with periods of excess carbohydrates and periods without supplementation. Healthy persons remove blood glucose rapidly when glucose is in excess, but insulin-stimulated glucose disposal is reduced in insulin resistant and type 2 diabetic subjects. During a hyperinsulinemic euglycaemic clamp, 70-90 % of glucose disposal will be stored as muscle glycogen in healthy subjects. The glycogen stores in skeletal muscles are limited because an efficient feedback-mediated inhibition of glycogen synthase prevents accumulation. De novo lipid synthesis can contribute to glucose disposal when glycogen stores are filled. Exercise physiologists normally consider glycogen’s main function as energy substrate. Glycogen is the main energy substrate during exercise intensity above 70 % of maximal oxygen uptake (VO2max) and fatigue develops when the glycogen stores are depleted in the active muscles. After exercise, the rate of glycogen synthesis is increased to replete glycogen stores, and blood glucose is the substrate. Indeed insulin-stimulated glucose uptake and glycogen synthesis is elevated after exercise, which, from an evolutional point of view, will favour glycogen repletion and preparation for new “fight or flight” events. In the modern society, the reduced glycogen stores in skeletal muscles after exercise allows carbohydrates to be stored as muscle glycogen and prevents that glucose is channelled to de novo lipid synthesis, which over time will causes ectopic fat accumulation and insulin resistance. The reduction of skeletal muscle glycogen after exercise allows a healthy storage of carbohydrates after meals and prevents development of type 2 diabetes.
291 citations
Authors
Showing all 32719 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Petersen | 178 | 1091 | 153067 |
P. Chang | 170 | 2154 | 151783 |
Vaclav Vrba | 141 | 1298 | 95671 |
Milos Lokajicek | 139 | 1511 | 98888 |
Christopher D. Manning | 138 | 499 | 147595 |
Yves Sirois | 137 | 1334 | 95714 |
Rupert Leitner | 136 | 1201 | 90597 |
Gerald M. Reaven | 133 | 799 | 80351 |
Roberto Sacchi | 132 | 1186 | 89012 |
S. Errede | 132 | 1481 | 98663 |
Mark Neubauer | 131 | 1252 | 89004 |
Peter Kodys | 131 | 1262 | 85267 |
Panos A Razis | 130 | 1287 | 90704 |
Vit Vorobel | 130 | 919 | 79444 |
Jehad Mousa | 130 | 1226 | 86564 |