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Institution

Charles University in Prague

EducationPrague, Czechia
About: Charles University in Prague is a education organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 32392 authors who have published 74435 publications receiving 1804208 citations.


Papers
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Journal ArticleDOI
TL;DR: In this article, the authors provide contemporary data on the implementation of European guideline recommendations for lipid-lowering therapies (LLTs) across different settings and populations and how this impacts low-density lipoprotein cholesterol (LDL-C) goal achievement.
Abstract: Aims To provide contemporary data on the implementation of European guideline recommendations for lipid-lowering therapies (LLTs) across different settings and populations and how this impacts low-density lipoprotein cholesterol (LDL-C) goal achievement. Methods and results An 18 country, cross-sectional, observational study of patients prescribed LLT for primary or secondary prevention in primary or secondary care across Europe. Between June 2017 and November 2018, data were collected at a single visit, including LLT in the preceding 12 months and most recent LDL-C. Primary outcome was the achievement of risk-based 2016 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) LDL-C goal while receiving stabilized LLT; 2019 goal achievement was also assessed. Overall, 5888 patients (3000 primary and 2888 secondary prevention patients) were enrolled; 54% [95% confidence interval (CI) 52-56] achieved their risk-based 2016 goal and 33% (95% CI 32-35) achieved their risk-based 2019 goal. High-intensity statin monotherapy was used in 20% and 38% of very high-risk primary and secondary prevention patients, respectively. Corresponding 2016 goal attainment was 22% and 45% (17% and 22% for 2019 goals) for very high-risk primary and secondary prevention patients, respectively. Use of moderate-high-intensity statins in combination with ezetimibe (9%), or any LLT with PCSK9 inhibitors (1%), was low; corresponding 2016 and 2019 goal attainment was 53% and 20% (ezetimibe combination), and 67% and 58% (PCSK9i combination). Conclusion Gaps between clinical guidelines and clinical practice for lipid management across Europe persist, which will be exacerbated by the 2019 guidelines. Even with optimized statins, greater utilization of non-statin LLT is likely needed to reduce these gaps for patients at highest risk.

277 citations

Journal ArticleDOI
TL;DR: The notions tree-depth and upper chromatic number of a graph are defined and it is shown that the upper chromatics number coincides with the maximal function which can be locally demanded in a bounded coloring of any proper minor closed class of graphs.
Abstract: We define the notions tree-depth and upper chromatic number of a graph and show their relevance to local-global problems for graph partitions. In particular we show that the upper chromatic number coincides with the maximal function which can be locally demanded in a bounded coloring of any proper minor closed class of graphs. The rich interplay of these notions is applied to a solution of bounds of proper minor closed classes satisfying local conditions. In particular, we prove the following result:For every graph M and a finite set F of connected graphs there exists a (universal) graph U = U(M, F) ∈ Forbh(F) such that any graph G ∈ Forbh(F) which does not have M as a minor satisfies G → U (i.e. is homomorphic to U).This solves the main open problem of restricted dualities for minor closed classes and as an application it yields the bounded chromatic number of exact odd powers of any graph in an arbitrary proper minor closed class. We also generalize the decomposition theorem of DeVos et al. [M. DeVos, G. Ding, B. Oporowski, D.P. Sanders, B. Reed, P. Seymour, D. Vertigan, Excluding any graph as a minor allows a low tree-width 2-coloring, J. Combin. Theory Ser. B 91 (2004) 25-41].

276 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present a detailed inventory of the Variscan Bohemian Massif as a result of Early Devonian subduction of the Saxothuringian ocean of unknown size underneath the eastern continental plate represented by the present-day Tepla-Barrandian and Moldanubian domains.

276 citations

Journal ArticleDOI
TL;DR: The All Sky Automated Survey for Supernovae (ASASAS-SN) is the first optical survey to routinely monitor the whole sky with a cadence of 2-3 days down to V$\lesssim17$ mag as discussed by the authors.
Abstract: The All-Sky Automated Survey for Supernovae (ASAS-SN) is the first optical survey to routinely monitor the whole sky with a cadence of $\sim2-3$ days down to V$\lesssim17$ mag. ASAS-SN has monitored the whole sky since 2014, collecting $\sim100-500$ epochs of observations per field. The V-band light curves for candidate variables identified during the search for supernovae are classified using a random forest classifier and visually verified. We present a catalog of 66,179 bright, new variable stars discovered during our search for supernovae, including 27,479 periodic variables and 38,700 irregular variables. V-band light curves for the ASAS-SN variables are available through the ASAS-SN variable stars database (this https URL). The database will begin to include the light curves of known variable stars in the near future along with the results for a systematic, all-sky variability survey.

276 citations


Authors

Showing all 32719 results

NameH-indexPapersCitations
Ronald C. Petersen1781091153067
P. Chang1702154151783
Vaclav Vrba141129895671
Milos Lokajicek139151198888
Christopher D. Manning138499147595
Yves Sirois137133495714
Rupert Leitner136120190597
Gerald M. Reaven13379980351
Roberto Sacchi132118689012
S. Errede132148198663
Mark Neubauer131125289004
Peter Kodys131126285267
Panos A Razis130128790704
Vit Vorobel13091979444
Jehad Mousa130122686564
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023203
2022554
20214,838
20204,793
20194,421
20183,991