Institution
Charles University in Prague
Education•Prague, Czechia•
About: Charles University in Prague is a education organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 32392 authors who have published 74435 publications receiving 1804208 citations.
Topics: Population, Large Hadron Collider, Czech, Magnetization, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: The aim of the study was to define distinctive features of FCD subtypes and establish a hierarchy of histopathological types of F CD.
Abstract: Objective
Focal cortical dysplasia (FCD) is the most frequent pathological finding in pediatric epilepsy surgery patients. Several histopathological types of FCD are distinguished. The aim of the study was to define distinctive features of FCD subtypes.
Methods
We retrospectively reviewed clinical, electroencephalographic, magnetic resonance imaging, neuropsychological, and surgical variables, and seizure outcome data in 200 children. Cortical malformations were histopathologically confirmed in all patients, including mild malformation of cortical development type II (mMCD) in 36, FCD type Ia in 55, FCD type Ib in 39, FCD type IIa in 35, and FCD type IIb in 35 subjects.
Results
Perinatal risk factors were more frequent in mMCD/FCD type I than FCD type II. Children with FCD type IIb had more localized ictal electroencephalographic patterns and magnetic resonance imaging changes. Increased cortical thickness, abnormal gyral/sulcal patterns, gray/white matter junction blurring, and gray matter signal abnormality in fluid-attenuated inversion recovery and T2-weighted sequences occurred more often in FCD type II, were infrequent in FCD type I, and rare in mMCD. Lobar hypoplasia/atrophy was common in FCD type I. Hippocampal sclerosis was most frequent in FCD type I. Neuropsychological testing demonstrated no significant differences between the groups. There was a trend toward better surgical outcomes in FCD type II compared with FCD type I patients.
Interpretation
Different histopathological types of mMCD/FCD have distinct clinical and imaging characteristics. The ability to predict the subtype before surgery could influence surgical planning. Invasive electroencephalographic study should be considered when mMCD/FCD type I is expected based on noninvasive tests. Ann Neurol 2008;63:758–769
251 citations
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TL;DR: In this paper, a detailed study of the behavior of pair exchange interactions as a function of the distance between magnetic atoms as well as the concentrations of the magnetic atoms and compensating defects is presented.
Abstract: Effective pair exchange interactions between Mn atoms in III-V and group-IV diluted magnetic semiconductors are determined from a two-step first-principles procedure. In the first step, the self-consistent electronic structure of a system is calculated for a collinear spin structure at zero temperature with the substitutional disorder treated within the framework of the coherent-potential approximation. The effective exchange pair interactions are then obtained in a second step by mapping the total energies associated with rotations of magnetic moments onto an effective classical Heisenberg Hamiltonian using the magnetic force theorem and one-electron Green functions. The formalism is applied to ${\mathrm{Ga}}_{1\ensuremath{-}x}{\mathrm{Mn}}_{x}\mathrm{As}$ alloys with and without As antisites, and to ${\mathrm{Ge}}_{1\ensuremath{-}x}{\mathrm{Mn}}_{x}$ alloys recently studied experimentally. A detailed study of the behavior of pair exchange interactions as a function of the distance between magnetic atoms as well as a function of the concentrations of the magnetic atoms and compensating defects is presented. We have found that due to disorder and the half-metallic character of the system the pair exchange interactions are exponentially damped with increasing distance between the Mn atoms. The exchange interactions between Mn atoms are ferromagnetic for distances larger than the ones corresponding to the averaged nearest-neighbor Mn-Mn distance. The pair exchange interactions are also reduced with increasing concentrations of the Mn atoms and As antisites. As a simple application of the calculated exchange interactions we present mean-field estimates of Curie temperatures.
251 citations
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University of Palermo1, University of Illinois at Chicago2, University of Chicago3, New York Medical College4, Aristotle University of Thessaloniki5, University of Belgrade6, University of Amsterdam7, University of Queensland8, University of Ljubljana9, University of Kansas10, University of Alabama11, Charles University in Prague12, University of Adelaide13, Apollo Hospitals14, University of California, Los Angeles15, University of Pécs16, Johns Hopkins University17, Imperial College London18, University College London19
TL;DR: The aim of this position paper was to suggest a unified definition of statin intolerance, and to complement the recent EAS statement on SAMS, where the pathophysiology, diagnosis and the management were comprehensively presented.
Abstract: Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are muscle-related. The recent statement of the European Atherosclerosis Society (EAS) has focused on statin-associated muscle symptoms (SAMS), and avoided the use of the term ‘statin intolerance’. Although muscle syndromes are the most common adverse effects observed after statin therapy, excluding other side effects might underestimate the number of patients with statin intolerance, which might be observed in 10 – 15% of patients.In clinical practice, statin intolerance limits effective treatment of patients at risk of, or with, cardiovascular disease. Knowledge of the most common adverse effects of statin therapy that might cause statin intolerance and the clear definition of this phenomenon is crucial to effectively treat patients with lipid disorders. Therefore, the aim of this position paper was ...
250 citations
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TL;DR: These European Resuscitation Council (ERC) Cardiac Arrest in Special Circumstances guidelines are based on the 2020 International Consensus on Cardiopulmonary Resusitation Science with Treatment Recommendations as mentioned in this paper.
250 citations
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20 Nov 2009
TL;DR: In this paper, the authors reported the detection of gamma rays from the starburst galaxy NGC 253 using the H.E.S. array of imaging atmospheric Cherenkov telescopes.
Abstract: Starburst galaxies exhibit in their central regions a highly increased rate of supernovae, the remnants of which are thought to accelerate energetic cosmic rays up to energies of ~ 10^15 eV. We report the detection of gamma rays -- tracers of such cosmic rays -- from the starburst galaxy NGC 253 using the H.E.S.S. array of imaging atmospheric Cherenkov telescopes. The gamma-ray flux above 220 GeV is F = (5.5 +/- 1.0stat +/- 2.8sys) x 10^-13 ph. s-1 cm-2, implying a cosmic-ray density about three orders of magnitude larger than that in the center of the Milky Way. The fraction of cosmic-ray energy channeled into gamma rays in this starburst environment is 5 times larger than that in our Galaxy.
250 citations
Authors
Showing all 32719 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Petersen | 178 | 1091 | 153067 |
P. Chang | 170 | 2154 | 151783 |
Vaclav Vrba | 141 | 1298 | 95671 |
Milos Lokajicek | 139 | 1511 | 98888 |
Christopher D. Manning | 138 | 499 | 147595 |
Yves Sirois | 137 | 1334 | 95714 |
Rupert Leitner | 136 | 1201 | 90597 |
Gerald M. Reaven | 133 | 799 | 80351 |
Roberto Sacchi | 132 | 1186 | 89012 |
S. Errede | 132 | 1481 | 98663 |
Mark Neubauer | 131 | 1252 | 89004 |
Peter Kodys | 131 | 1262 | 85267 |
Panos A Razis | 130 | 1287 | 90704 |
Vit Vorobel | 130 | 919 | 79444 |
Jehad Mousa | 130 | 1226 | 86564 |