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Institution

Charles University in Prague

EducationPrague, Czechia
About: Charles University in Prague is a education organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 32392 authors who have published 74435 publications receiving 1804208 citations.


Papers
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Journal ArticleDOI
A. Aab1, P. Abreu2, Marco Aglietta3, E. J. Ahn4  +481 moreInstitutions (53)
TL;DR: In this article, the authors examined the implications of the distributions of the depths of atmospheric shower maximum (X-max) using a hybrid technique, for composition and hadronic interaction models, and found that their data are not well described by a mix of protons and iron nuclei over most of the energy range.
Abstract: Using the data taken at the Pierre Auger Observatory between December 2004 and December 2012, we have examined the implications of the distributions of depths of atmospheric shower maximum (X-max), using a hybrid technique, for composition and hadronic interaction models. We do this by fitting the distributions with predictions from a variety of hadronic interaction models for variations in the composition of the primary cosmic rays and examining the quality of the fit. Regardless of what interaction model is assumed, we find that our data are not well described by a mix of protons and iron nuclei over most of the energy range. Acceptable fits can be obtained when intermediate masses are included, and when this is done consistent results for the proton and iron-nuclei contributions can be found using the available models. We observe a strong energy dependence of the resulting proton fractions, and find no support from any of the models for a significant contribution from iron nuclei. However, we also observe a significant disagreement between the models with respect to the relative contributions of the intermediate components.

244 citations

Journal ArticleDOI
TL;DR: It is found that the core of a finite graph is unique (up to isomorphism) and is also its smallest retract, and some homomorphism properties of cores are investigated, concluding that it is NP-complete to decide whether a graph is its own core.

244 citations

Journal ArticleDOI
TL;DR: By comparison with historical natural history data for patients with Fabry's disease who were not treated with enzyme replacement therapy, long-term treatment with agalsidase alfa leads to substantial and sustained clinical benefits.

244 citations

Journal ArticleDOI
TL;DR: The primary clinical applications for FISH analysis were for newly diagnosed cases of MM or frank relapse cases and prospective analysis should be centralized for upcoming trials based on the recommendations made.
Abstract: The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic cases of purified plasma cells for recurrent abnormalities. The summary report was discussed at the EHA Myeloma Scientific Working Group Meeting 2010. During the quality control exercise, there was acceptable agreement on more than 1,000 tests. The conclusions from the exercise were that the primary clinical applications for FISH analysis were for newly diagnosed cases of MM or frank relapse cases. A range of technical recommendations included: 1) material should be part of the first draw of the aspirate; 2) samples should be sent at suitable times to allow for the lengthy processing procedure; 3) most importantly, PCs must be purified or specifically identified; 4) positive cut-off levels should be relatively conservative: 10% for fusion or break-apart probes, 20% for numerical abnormalities; 5) informative probes should be combined to best effect; 6) in specialist laboratories, a single experienced analyst is considered adequate; 7) at least 100 PC should be scored; 8) essential abnormalities to test for are t(4;14), t(14;16) and 17p13 deletions; 9) suitable commercial probes should be available for clinically relevant abnormalities; 10) the clinical report should be expressed clearly and must state the percentage of PC involved and the method used for identification; 11) a retrospective European based FISH data bank linked to clinical data should be generated; and 12) prospective analysis should be centralized for upcoming trials based on the recommendations made. The European Myeloma Network aims to build on these recommendations to establish standards for a common European data base to define subgroups with prognostic significance.

244 citations


Authors

Showing all 32719 results

NameH-indexPapersCitations
Ronald C. Petersen1781091153067
P. Chang1702154151783
Vaclav Vrba141129895671
Milos Lokajicek139151198888
Christopher D. Manning138499147595
Yves Sirois137133495714
Rupert Leitner136120190597
Gerald M. Reaven13379980351
Roberto Sacchi132118689012
S. Errede132148198663
Mark Neubauer131125289004
Peter Kodys131126285267
Panos A Razis130128790704
Vit Vorobel13091979444
Jehad Mousa130122686564
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023203
2022554
20214,838
20204,793
20194,421
20183,991