Institution
Charles University in Prague
Education•Prague, Czechia•
About: Charles University in Prague is a education organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 32392 authors who have published 74435 publications receiving 1804208 citations.
Topics: Population, Large Hadron Collider, Czech, Magnetization, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the results of the four LEP experiments were combined to determine fundamental properties of the W boson and the electroweak theory, including the branching fraction of W and the trilinear gauge-boson self-couplings.
684 citations
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TL;DR: Substantial differences in potentially inappropriate medication use exist between European countries and might be a consequence of different regulatory measures, clinical practices, or inequalities in socioeconomic background.
Abstract: ContextCriteria for potentially inappropriate medication use among elderly
patients have been used in the past decade in large US epidemiological surveys
to identify populations at risk and specifically target risk-management strategies.
In contrast, in Europe little information is available about potentially inappropriate
medication use and is based on small studies with uncertain generalizability.ObjectiveTo estimate the prevalence and associated factors of potentially inappropriate
medication use among elderly home care patients in European countries.Design, Setting, and ParticipantsRetrospective cross-sectional study of 2707 elderly patients receiving
home care (mean [SD] age, 82.2 [ 7.2] years) representatively enrolled
in metropolitan areas of the Czech Republic, Denmark, Finland, Iceland, Italy,
the Netherlands, Norway, and the United Kingdom. Patients were prospectively
assessed between September 2001 and January 2002 using the Minimum Data Set
in Home Care instrument.Main Outcome MeasuresPrevalence of potentially inappropriate medication use was documented
using all expert panels criteria for community-living elderly persons (Beers
and McLeod). Patient-related characteristics independently associated with
inappropriate medication use were identified with a multiple logistic regression
model.ResultsCombining all 3 sets of criteria, we found that 19.8% of patients in
the total sample used at least 1 inappropriate medication; using older 1997
criteria it was 9.8% to 10.9%. Substantial differences were documented between
Eastern Europe (41.1% in the Czech Republic) and Western Europe (mean 15.8%,
ranging from 5.8% in Denmark to 26.5% in Italy). Potentially inappropriate
medication use was associated with patient’s poor economic situation
(adjusted relative risk [RR], 1.96; 95% confidence interval [CI], 1.58-2.36),
polypharmacy (RR, 1.91; 95% CI, 1.62- 2.22), anxiolytic drug use (RR, 1.82;
95% CI, 1.51-2.15), and depression (RR, 1.29; 95% CI, 1.06-1.55). Negatively
associated factors were age 85 years and older (RR, 0.78; 95% CI, 0.65-0.92)
and living alone (RR, 0.76; 95% CI, 0.64-0.89). The odds of potentially inappropriate
medication use significantly increased with the number of associated factors
(P<.001).ConclusionsSubstantial differences in potentially inappropriate medication use
exist between European countries and might be a consequence of different regulatory
measures, clinical practices, or inequalities in socioeconomic background.
Since financial resources and selected patient-related characteristics are
associated with such prescribing, specific educational strategies and regulations
should reflect these factors to improve prescribing quality in elderly individuals
in Europe.
682 citations
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TL;DR: Several lines of evidence suggest that mechanisms other than the traditionally emphasized "ROS and iron" hypothesis are involved in anthracycline-induced cardiotoxicity and that these alternative mechanisms may be better bases for designing approaches to achieve efficient and safe cardioprotection.
682 citations
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TL;DR: The progression from proliferating microspores to terminally differentiated pollen is characterized by large-scale repression of early program genes and the activation of a unique late gene-expression program in maturing pollen.
Abstract: Background: The haploid male gametophyte generation of flowering plants consists of two- or three-celled pollen grains. This functional specialization is thought to be a key factor in the evolutionary success of flowering plants. Moreover, pollen ontogeny is also an attractive model in which to dissect cellular networks that control cell growth, asymmetric cell division and cellular differentiation. Our objective, and an essential step towards the detailed understanding of these processes, was to comprehensively define the male haploid transcriptome throughout development. Results: We have developed staged spore isolation procedures for Arabidopsis and used Affymetrix ATH1 genome arrays to identify a total of 13,977 male gametophyte-expressed mRNAs, 9.7% of which were male-gametophyte-specific. The transition from bicellular to tricellular pollen was accompanied by a decline in the number of diverse mRNA species and an increase in the proportion of male gametophyte-specific transcripts. Expression profiles of regulatory proteins and distinct clusters of coexpressed genes were identified that could correspond to components of gametophytic regulatory networks. Moreover, integration of transcriptome and experimental data revealed the early synthesis of translation factors and their requirement to support pollen tube growth. Conclusions: The progression from proliferating microspores to terminally differentiated pollen is characterized by large-scale repression of early program genes and the activation of a unique late gene-expression program in maturing pollen. These data provide a quantum increase in knowledge concerning gametophytic transcription and lay the foundations for new genomic-led studies of the regulatory networks and cellular functions that operate to specify male gametophyte development.
680 citations
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Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam +2134 more•Institutions (142)
TL;DR: The couplings of the Higgs boson are probed for deviations in magnitude from the standard model predictions in multiple ways, including searches for invisible and undetected decays, and no significant deviations are found.
Abstract: Properties of the Higgs boson with mass near 125 GeV are measured in proton-proton collisions with the CMS experiment at the LHC. Comprehensive sets of production and decay measurements are combined. The decay channels include gamma gamma, ZZ, WW, tau tau, bb, and mu mu pairs. The data samples were collected in 2011 and 2012 and correspond to integrated luminosities of up to 5.1 inverse femtobarns at 7 TeV and up to 19.7 inverse femtobarns at 8 TeV. From the high-resolution gamma gamma and ZZ channels, the mass of the Higgs boson is determined to be 125.02 +0.26 -0.27 (stat) +0.14 -0.15 (syst) GeV. For this mass value, the event yields obtained in the different analyses tagging specific decay channels and production mechanisms are consistent with those expected for the standard model Higgs boson. The combined best-fit signal relative to the standard model expectation is 1.00 +/- 0.09 (stat) +0.08 -0.07 (theo) +/- 0.07 (syst) at the measured mass. The couplings of the Higgs boson are probed for deviations in magnitude from the standard model predictions in multiple ways, including searches for invisible and undetected decays. No significant deviations are found.
677 citations
Authors
Showing all 32719 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Petersen | 178 | 1091 | 153067 |
P. Chang | 170 | 2154 | 151783 |
Vaclav Vrba | 141 | 1298 | 95671 |
Milos Lokajicek | 139 | 1511 | 98888 |
Christopher D. Manning | 138 | 499 | 147595 |
Yves Sirois | 137 | 1334 | 95714 |
Rupert Leitner | 136 | 1201 | 90597 |
Gerald M. Reaven | 133 | 799 | 80351 |
Roberto Sacchi | 132 | 1186 | 89012 |
S. Errede | 132 | 1481 | 98663 |
Mark Neubauer | 131 | 1252 | 89004 |
Peter Kodys | 131 | 1262 | 85267 |
Panos A Razis | 130 | 1287 | 90704 |
Vit Vorobel | 130 | 919 | 79444 |
Jehad Mousa | 130 | 1226 | 86564 |