Charles University in Prague

About: Charles University in Prague is a education organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 32392 authors who have published 74435 publications receiving 1804208 citations.

CoNLL 2018 Shared Task : Multilingual Parsing from Raw Text to Universal Dependencies

Abstract: Every year, the Conference on Computational Natural Language Learning (CoNLL) features a shared task, in which participants train and test their learning systems on the same data sets. In 2018, one of two tasks was devoted to learning dependency parsers for a large number of languages, in a real-world setting without any gold-standard annotation on test input. All test sets followed a unified annotation scheme, namely that of Universal Dependencies. This shared task constitutes a 2nd edition—the first one took place in 2017 (Zeman et al., 2017); the main metric from 2017 has been kept, allowing for easy comparison, also in 2018, and two new main metrics have been used. New datasets added to the Universal Dependencies collection between mid-2017 and the spring of 2018 have contributed to increased difficulty of the task this year. In this overview paper, we define the task and the updated evaluation methodology, describe data preparation, report and analyze the main results, and provide a brief categorization of the different approaches of the participating systems.

Common Patterns of Prediction of Literacy Development in Different Alphabetic Orthographies

Abstract: Previous studies have shown that phoneme awareness, letter-sound knowledge, rapid automatized naming (RAN), and verbal memory span are reliable correlates of learning to read in English. However, the extent to which these different predictors have the same relative importance in different languages remains uncertain. In this article, we present the results from a 10-month longitudinal study that began just before or soon after the start of formal literacy instruction in four languages (English, Spanish, Slovak, and Czech). Longitudinal path analyses showed that phoneme awareness, letter-sound knowledge, and RAN (but not verbal memory span) measured at the onset of literacy instruction were reliable predictors, with similar relative importance, of later reading and spelling skills across the four languages. These data support the suggestion that in all alphabetic orthographies, phoneme awareness, letter-sound knowledge, and RAN may tap cognitive processes that are important for learning to read.

Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes

Abstract: The small/short heterodimer partner (SHP, NR0B2) is a nuclear receptor corepressor lacking a DNA binding domain. SHP is induced by bile acid-activated farnesoid X receptor (FXR) resulting in CYP7A1 gene suppression. In contrast, Pregnane X receptor (PXR) activation by its ligands was recently suggested to inhibit SHP gene transactivation to maximize the induction of PXR target genes. However, there are also conflicting reports in literature whether PXR or rodent Pxr activation down-regulates SHP/Shp expression. Moreover, the PXR-mediated regulation of the SHP gene has been studied only at the SHP mRNA and transactivation (gene reporter assay) levels. In this study, we studied the effect of rifampicin, a prototype PXR ligand, on SHP mRNA and protein expression in three primary human hepatocyte cultures. We found that SHP mRNA is not systematically down-regulated in hepatocyte in culture after 24 h treatment with rifampicin. Consistently, we did not observe down-regulation of SHP protein in primary human hepatocytes after 24 and 48 h of incubation with rifampicin. We can conclude that although we observed slight down-regulation of SHP mRNA and protein in several hepatocyte preparations, the phenomenon is unlikely critical for PXR-mediated induction of its target genes.

Writing and reading antiferromagnetic Mn2Au by Néel spin-orbit torques and large anisotropic magnetoresistance.

Abstract: Using antiferromagnets as active elements in spintronics requires the ability to manipulate and read-out the Neel vector orientation. Here we demonstrate for Mn2Au, a good conductor with a high ordering temperature suitable for applications, reproducible switching using current pulse generated bulk spin-orbit torques and read-out by magnetoresistance measurements. Reversible and consistent changes of the longitudinal resistance and planar Hall voltage of star-patterned epitaxial Mn2Au(001) thin films were generated by pulse current densities of ≃107 A/cm2. The symmetry of the torques agrees with theoretical predictions and a large read-out magnetoresistance effect of more than ≃6% is reproduced by ab initio transport calculations.

Simulated annealing: a proof of convergence

Abstract: We prove the convergence of the simulated annealing procedure when the decision to change the current configuration is blind of the cost of the new configuration. In case of filtering binary images, the proof easily generalizes to other procedures, including that of Metropolis. We show that a function Q associated with the algorithm must be chosen as large as possible to provide a fast rate of convergence. The worst case (Q constant) is associated with the "blind" algorithm. On the other hand, an appropriate Q taking sufficiently high values yields a better rate of convergence than that of Metropolis procedure. >