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Institution

Charlie Norwood VA Medical Center

HealthcareAugusta, Georgia, United States
About: Charlie Norwood VA Medical Center is a healthcare organization based out in Augusta, Georgia, United States. It is known for research contribution in the topics: Autophagy & Kidney. The organization has 349 authors who have published 490 publications receiving 16360 citations. The organization is also known as: Augusta VA Medical Center.


Papers
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Journal ArticleDOI
TL;DR: It is suggested that ciliary regulation by ERK plays a role in cisplatin-induced tubular apoptosis and AKI, and U0126 prevented the loss of cilia from proximal tubules during cisPlatin treatment and protected against AKI.

56 citations

Journal ArticleDOI
TL;DR: The results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation, consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis, and inhibition of proinflammatory cytokine production.
Abstract: Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However, the underlying molecular mechanism remains unclear. In this study, we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3, and inhibited the expression of fibronectin, alpha-smooth muscle actin (α-SMA), and collagen I in cultured NRK-49F cells. S3I-201, an STAT3 inhibitor, also suppressed the expression of fibronectin, α-SMA, and collagen I in cultured NRK-49F cells. Mechanistically, paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore, paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin, α-SMA, and collagen I, and suppressed the infiltration of macrophages and production of TNF-α, IL-1β, TGF-β, and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation, consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis, and inhibition of proinflammatory cytokine production.

56 citations

Journal ArticleDOI
TL;DR: The Ang II-induced genes in adrenocortical cells are discussed and the progress in defining the role of these genes in zona glomerulosa function is reviewed.

56 citations

Journal ArticleDOI
TL;DR: Low arterial elasticity is associated with stenosis and fistula maturation failure, however, vessel dilatation is not needed for adequate blood flow except at the smaller diameters in this study.
Abstract: Background Arteriovenous fistula maturation requires dilatation of the anastomosed artery and vein. The factors that affect dilatation and the mechanisms by which dilatation promotes maturation are not understood. This pilot study tested two hypotheses: that low arterial elasticity is associated with maturation failure, and that vessel dilatation is required for adequate fistula blood flow during dialysis. Methods Thirty-two patients underwent preoperative measurement of small artery elasticity index, and pre-anastomosis measurement of artery and vein luminal diameters during fistula surgery. Fistulas were considered mature if they were used successfully in three consecutive treatments within 6 months. A mathematical model was used to determine whether vessel dilatation is needed for adequate fistula flow. Results Six fistulas were excluded from analysis of maturation because dialysis did not begin within 6 months. Twenty-one of the remaining 26 fistulas were located in the upper arm. Six of 26 failed to mature, and all 6 developed stenosis. The average small artery elasticity index was lower in failed than in matured fistulas (2.25 versus 3.71 ml/ mmHg x 100, P = 0.02). Artery and vein diameters of the 32 patients ranged from 2.5 to 5.0 and 3.5 to 7.0 mm, respectively. When the diameters were applied to the mathematical model, predicted fistula flows ranged from 412 to 1380 ml/min. Conclusions Low arterial elasticity is associated with stenosis and fistula maturation failure. However, vessel dilatation is not needed for adequate blood flow except at the smaller diameters in this study. We speculate that low elasticity promotes development of stenosis. Larger studies are needed to confirm these promising results and to determine whether therapies directed at improving elasticity can improve maturation.

55 citations

Journal ArticleDOI
07 Dec 2016-Neuron
TL;DR: A previously unappreciated enzymatic function of rapsyn and a role of neddylation in synapse formation are identified, and a potential target of therapeutic intervention for relevant neurological disorders is revealed.

55 citations


Authors

Showing all 353 results

NameH-indexPapersCitations
Zheng Dong7028324123
Lin Mei6924515903
Wen Cheng Xiong6419412171
Ruth B. Caldwell6021412314
Darrell W. Brann6018811066
Steven S. Coughlin5630312401
Martha K. Terris5537512346
Susan C. Fagan5317910135
Adviye Ergul481887678
Kebin Liu461287271
Maribeth H. Johnson451255189
Azza B. El-Remessy441235746
Yutao Liu431525657
William D. Hill411019870
Yuqing Huo411149815
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20226
202163
202050
201942
201846