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Institution

Charlie Norwood VA Medical Center

HealthcareAugusta, Georgia, United States
About: Charlie Norwood VA Medical Center is a healthcare organization based out in Augusta, Georgia, United States. It is known for research contribution in the topics: Autophagy & Kidney. The organization has 349 authors who have published 490 publications receiving 16360 citations. The organization is also known as: Augusta VA Medical Center.


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Journal ArticleDOI
TL;DR: In this paper , the role of microRNAs in cold storage-associated transplantation (CST) kidney injury was examined in mouse and renal tubular cell models, and anti-microRNA-147 and miR-147 mimic were used for kidney transplantation.
Abstract: Kidney injury due to cold storage-associated transplantation (CST) is a major factor determining the outcome of renal transplant, for which the role and regulation of microRNAs remain largely unclear.The kidneys of proximal tubule Dicer (an enzyme for microRNA biogenesis) knockout mice and their wild-type littermates were subjected to CST to determine the function of microRNAs. Small RNA sequencing then profiled microRNA expression in mouse kidneys after CST. Anti-microRNA-147 (miR-147) and miR-147 mimic were used to examine the role of miR-147 in CST injury in mouse and renal tubular cell models.Knockout of Dicer from proximal tubules attenuated CST kidney injury in mice. RNA sequencing identified multiple microRNAs with differential expression in CST kidneys, among which miR-147 was induced consistently in mouse kidney transplants and in dysfunctional human kidney grafts. Anti-miR-147 protected against CST injury in mice and ameliorated mitochondrial dysfunction after ATP depletion injury in renal tubular cells in intro . Mechanistically, miR-147 was shown to target NDUFA4, a key component of the mitochondrial respiration complex. Silencing NDUFA4 aggravated renal tubular cell death, whereas overexpression of NDUFA4 prevented miR-147-induced cell death and mitochondrial dysfunction. Moreover, overexpression of NDUFA4 alleviated CST injury in mice.microRNAs, as a class of molecules, are pathogenic in CST injury and graft dysfunction. Specifically, miR-147 induced during CST represses NDUFA4, leading to mitochondrial damage and renal tubular cell death. These results unveil miR-147 and NDUFA4 as new therapeutic targets in kidney transplantation.

1 citations

Journal ArticleDOI
03 Jun 2021
TL;DR: This review will focus on how mineral homeostasis is impacted by aging with a particular emphasis on the kidney's role in this process, including fibroblast growth factor 23 produced by the bone and calcitriol synthesized by the kidney.
Abstract: Aging results in a general decline in function in most systems. This is particularly true with respect to the skeleton and renal systems, impacting mineral homeostasis. Calcium and phosphate regulation requires tight coordination among the intestine, bone, parathyroid gland, and kidney. The role of the intestine is to absorb calcium and phosphate from the diet. The bone stores or releases calcium and phosphate depending on the body's needs. In response to low plasma ionized calcium concentration, the parathyroid gland produces parathyroid hormone, which modulates bone turnover. The kidney reabsorbs or excretes the minerals and serves as the final regulator of plasma concentration. Many hormones are involved in this process in addition to parathyroid hormone, including fibroblast growth factor 23 produced by the bone and calcitriol synthesized by the kidney. Sclerostin, calcitonin, osteoprotegerin, and receptor activator of nuclear factor-κB ligand also contribute to tissue-specific regulation. Changes in the function of organs due to aging or disease can perturb this balance. During aging, the intestine cannot absorb calcium efficiently due to decreased expression of key proteins. In the bone, the balance between bone formation and bone resorption tends toward the latter in older individuals. The kidney may not filter blood as efficiently in the later decades of life, and the expression of certain proteins necessary for mineral homeostasis declines with age. These changes often lead to dysregulation of organismal mineral homeostasis. This review will focus on how mineral homeostasis is impacted by aging with a particular emphasis on the kidney's role in this process. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

1 citations

Journal ArticleDOI
TL;DR: As the largest study of SEA to date, this report identifies important risk factors for SEA in ESRD patients, and novel data regarding their mortality-associated risk factors.

1 citations

Journal ArticleDOI
TL;DR: In this article, the circumferential crescents lesion was associated with adverse outcomes in immunoglobulin A nephropathy (IgAN) and more than one-fifth of glomeruli circumferentions was an independent predictor of 30% eGFR decline after adjusting for clinical and histological parameters.

1 citations


Authors

Showing all 353 results

NameH-indexPapersCitations
Zheng Dong7028324123
Lin Mei6924515903
Wen Cheng Xiong6419412171
Ruth B. Caldwell6021412314
Darrell W. Brann6018811066
Steven S. Coughlin5630312401
Martha K. Terris5537512346
Susan C. Fagan5317910135
Adviye Ergul481887678
Kebin Liu461287271
Maribeth H. Johnson451255189
Azza B. El-Remessy441235746
Yutao Liu431525657
William D. Hill411019870
Yuqing Huo411149815
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20226
202163
202050
201942
201846