Institution
China Medical University (PRC)
Education•Shenyang, China•
About: China Medical University (PRC) is a education organization based out in Shenyang, China. It is known for research contribution in the topics: Cancer & Population. The organization has 34377 authors who have published 26442 publications receiving 377688 citations.
Topics: Cancer, Population, Apoptosis, Cell growth, Metastasis
Papers published on a yearly basis
Papers
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City of Hope National Medical Center1, University of Cincinnati Academic Health Center2, Sun Yat-sen University3, University of Chicago4, Howard Hughes Medical Institute5, China Medical University (PRC)6, Cincinnati Children's Hospital Medical Center7, Martin Luther University of Halle-Wittenberg8, Zhejiang University9
TL;DR: This work reports the insulin-like growth factor 2 mRNA-binding proteins as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence, and identifies IGF2BPs as an additional class of N6-methyladenosine (m 6A) reader proteins.
Abstract: N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence. In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Moreover, the K homology domains of IGF2BPs are required for their recognition of m6A and are critical for their oncogenic functions. Thus, our work reveals a different facet of the m6A-reading process that promotes mRNA stability and translation, and highlights the functional importance of IGF2BPs as m6A readers in post-transcriptional gene regulation and cancer biology.
1,373 citations
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TL;DR: The coronavirus disease 2019 (COVID-19) epidemic has now spread across China for over a month, and Xiang and colleagues, claim that the mental health needs of patients with confirmed CO VID-19, patients with suspected infection, quarantined family members, and medical personnel have been poorly handled.
1,244 citations
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TL;DR: It is suggested that all the potential interventions be implemented to control the emerging COVID‐19 if the infection is uncontrollable and the current children's RNA‐virus vaccines including influenza vaccine should be immunized for uninfected people and health care workers.
Abstract: An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA-virus infection and we have found that general treatments, coronavirus-specific treatments, and antiviral treatments should be useful in fighting COVID-19. We suggest that the nutritional status of each infected patient should be evaluated before the administration of general treatments and the current children's RNA-virus vaccines including influenza vaccine should be immunized for uninfected people and health care workers. In addition, convalescent plasma should be given to COVID-19 patients if it is available. In conclusion, we suggest that all the potential interventions be implemented to control the emerging COVID-19 if the infection is uncontrollable.
1,009 citations
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TL;DR: It is demonstrated that H19 modulates let-7 availability by acting as a molecular sponge, and this lncRNA is identified as an important regulator of the majorLet-7 family of microRNAs.
920 citations
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TL;DR: Evaluating the efficiency of CSF–ISF exchange and interstitial solute clearance is impaired in the aging brain found that bulk flow drainage via the glymphatic system is driven by cerebrovascular pulsation, and is dependent on astroglial water channels that line paravascular CSF pathways.
Abstract: Objective: In the brain, protein waste removal is partly performed by paravascular pathways that facilitate convective exchange of water and soluble contents between cerebrospinal fluid (CSF) and interstitial fluid (ISF). Several lines of evidence suggest that bulk flow drainage via the glymphatic system is driven by cerebrovascular pulsation, and is dependent on astroglial water channels that line paravascular CSF pathways. The objective of this study was to evaluate whether the efficiency of CSF–ISF exchange and interstitial solute clearance is impaired in the aging brain. Methods: CSF–ISF exchange was evaluated by in vivo and ex vivo fluorescence microscopy and interstitial solute clearance was evaluated by radiotracer clearance assays in young (2–3 months), middle-aged (10–12 months), and old (18–20 months) wild-type mice. The relationship between age-related changes in the expression of the astrocytic water channel aquaporin-4 (AQP4) and changes in glymphatic pathway function was evaluated by immunofluorescence. Results: Advancing age was associated with a dramatic decline in the efficiency of exchange between the subarachnoid CSF and the brain parenchyma. Relative to the young, clearance of intraparenchymally injected amyloid-b was impaired by 40% in the old mice. A 27% reduction in the vessel wall pulsatility of intracortical arterioles and widespread loss of perivascular AQP4 polarization along the penetrating arteries accompanied the decline in CSF–ISF exchange. Interpretation: We propose that impaired glymphatic clearance contributes to cognitive decline among the elderly and may represent a novel therapeutic target for the treatment of neurodegenerative diseases associated with accumulation of misfolded protein aggregates. ANN NEUROL 2014;76:845–861
886 citations
Authors
Showing all 34486 results
Name | H-index | Papers | Citations |
---|---|---|---|
Frank B. Hu | 250 | 1675 | 253464 |
Wei Zheng | 151 | 1929 | 120209 |
Mien Chie Hung | 141 | 754 | 71633 |
Gavin Andrews | 112 | 822 | 58486 |
Jian Zhang | 107 | 3064 | 69715 |
Fei Wang | 107 | 1824 | 53587 |
Li Chen | 105 | 1732 | 55996 |
Yi Zhang | 102 | 1817 | 53417 |
Liang Wang | 98 | 1718 | 45600 |
Chawnshang Chang | 97 | 534 | 35629 |
Wei Wang | 95 | 3544 | 59660 |
Lu Qi | 94 | 566 | 54866 |
Po-Ren Hsueh | 92 | 1030 | 38811 |
Qian Liu | 90 | 610 | 33341 |
Alexei Verkhratsky | 89 | 450 | 29788 |