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Institution

Chinese Center for Disease Control and Prevention

GovernmentBeijing, China
About: Chinese Center for Disease Control and Prevention is a government organization based out in Beijing, China. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 16037 authors who have published 15098 publications receiving 423452 citations. The organization is also known as: China CDC & CCDC.


Papers
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Journal ArticleDOI
TL;DR: Interestingly, besides the activity against functional viral proteins, TF derivatives also decreased the expression level of the inflammatory cytokine IL-6 during viral infection, expression of which may result in serious tissue injury and apoptosis.

108 citations

Journal ArticleDOI
TL;DR: A sensitive and specific method for determination of the residues of 50 anabolic hormones in muscle, beef, shrimp, milk and pig liver was developed and has been successfully applied in real samples.

108 citations

Journal ArticleDOI
TL;DR: A novel tick-borne Bunyavirus causing life-threatening hemorrhagic fever in humans has emerged in the Huaiyangshan mountain areas of China and is likely to be closely related to the viruses of the genus Phlebovirus.
Abstract: Background From April to July in 2009 and 2010, unexplained severe hemorrhagic fever-like illnesses occurred in farmers from the Huaiyangshan mountains range. Methods Clinical specimens (blood, urine, feces, and throat swabs) from suspected patients were obtained and stored. Mosquitoes and ticks in affected regions were collected. Virus was isolated from 2 patients and characterized by whole genome sequencing. Virus detection in additional patients and arthropods was done by virus-specific reverse transcription (RT) PCR. Clinical and epidemiological data of RT-PCR confirmed patients were analyzed. Results An unknown virus was isolated from blood of two patients and from Haemaphysalis ticks collected from dogs. Whole genome sequence analysis identified the virus as a novel member of the family Bunyaviridae, most closely related to the viruses of the genus Phlebovirus within which it forms a separate lineage. Subsequently, infection was confirmed by RT-PCR in 33 of 58 suspected patients. The illness in these patients was characterized by fever, severe malaise, nausea, vomiting, and diarrhea. Prominent laboratory findings included low white cell- and platelet counts, coagulation disturbances, and elevation of liver enzymes. Hemorrhagic complications were observed in 3 cases, 5 (15%) patients died. Conclusions A novel tick-borne Bunyavirus causing life-threatening hemorrhagic fever in humans has emerged in the Huaiyangshan mountain areas of China. Further studies are needed to determine the epidemiology, geographic distribution and vertebrate animal ecology of this virus.

108 citations

Journal ArticleDOI
TL;DR: Findings indicate that when other food items or dietary patterns are accounted for, no association exists between MSG intake and weight gain.
Abstract: Animal studies and one large cross-sectional study of 752 healthy Chinese men and women suggest that monosodium glutamate (MSG) may be associated with overweight/obesity, and these findings raise public concern over the use of MSG as a flavour enhancer in many commercial foods The aim of this analysis was to investigate a possible association between MSG intake and obesity, and determine whether a greater MSG intake is associated with a clinically significant weight gain over 5 years Data from 1282 Chinese men and women who participated in the Jiangsu Nutrition Study were analysed In the present study, MSG intake and body weight were quantitatively assessed in 2002 and followed up in 2007 MSG intake was not associated with significant weight gain after adjusting for age, sex, multiple lifestyle factors and energy intake When total glutamate intake was added to the model, an inverse association between MSG intake and 5 % weight gain was found ( P = 0·028), but when the model was adjusted for either rice intake or food patterns, this association was abolished These findings indicate that when other food items or dietary patterns are accounted for, no association exists between MSG intake and weight gain

108 citations

Journal ArticleDOI
TL;DR: It is revealed that LAG-3 on T cells delivers an inhibitory signal to downregulate T cell functionality, thereby playing an immunoregulatory role during persistent HIV-1 infection and providing an important target for enhancing immune reconstitution in HIV-infected patients.
Abstract: T cells develop functional defects during HIV-1 infection, partially due to the upregulation of inhibitory receptors such as programmed death-1 (PD-1) and CTLA-4. However, the role of lymphocyte activation gene-3 (LAG-3; CD223), also known as an inhibitory receptor, in HIV infection remains to be determined. In this study, we revealed that LAG-3 on T cells delivers an inhibitory signal to downregulate T cell functionality, thereby playing an immunoregulatory role during persistent HIV-1 infection. We observed that HIV-1 infection results in a significant increase in LAG-3 expression in both the peripheral blood and the lymph nodes. The upregulation of LAG-3 is dramatically manifested on both CD4(+) and CD8(+) T cells and is correlated with disease progression. As expected, prolonged antiretroviral therapy reduces the expression of LAG-3 on both CD4(+) and CD8(+) T cells. The ex vivo blockade of LAG-3 significantly augments HIV-specific CD4(+) and CD8(+) T cell responses, whereas the overexpression of LAG-3 in T cells or the stimulation of LAG-3 on T cells leads to the reduction of T cell responses. Furthermore, most LAG-3 and PD-1 are expressed in different T cell subsets. Taken together, these data demonstrate that the LAG-3/MHC class II pathway plays an immunoregulatory role, thereby providing an important target for enhancing immune reconstitution in HIV-infected patients. Additionally, the LAG-3/MHC class II pathway may synergize with PD-1/PD ligand to enhance T cell-mediated immune responses.

108 citations


Authors

Showing all 16076 results

NameH-indexPapersCitations
Richard Peto183683231434
Barry M. Popkin15775190453
Jian Yang1421818111166
Edward C. Holmes13882485748
Jian Li133286387131
Shaobin Wang12687252463
Elaine Holmes11956058975
Jian Liu117209073156
Sherif R. Zaki10741740081
Jun Yang107209055257
Nan Lin10568754545
Li Chen105173255996
Ming Li103166962672
George F. Gao10279382219
Tao Li102248360947
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20235
202283
20211,490
20201,678
20191,244
20181,041