Institution
Chinese Center for Disease Control and Prevention
Government•Beijing, China•
About: Chinese Center for Disease Control and Prevention is a government organization based out in Beijing, China. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 16037 authors who have published 15098 publications receiving 423452 citations. The organization is also known as: China CDC & CCDC.
Topics: Population, Acquired immunodeficiency syndrome (AIDS), Virus, Vaccination, Men who have sex with men
Papers published on a yearly basis
Papers
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TL;DR: A trend of higher effect estimates of intermediate-term NO2 exposure on respiratory mortality compared to that of the short-term is observed, although the differences were not statistically significant.
97 citations
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Australian National University1, Deakin University2, Southwest University of Visual Arts3, University of Sydney4, University of the Western Cape5, Public Health Foundation of India6, University of Wollongong7, University of Pennsylvania8, University of Toronto9, Queensland University of Technology10, Chinese Center for Disease Control and Prevention11, University of São Paulo12, The George Institute for Global Health13, University of Oxford14, University of Auckland15, Global Alliance for Improved Nutrition16
TL;DR: The paper outlines an approach for monitoring the potential impact of trade agreements on food environments and obesity/NCD risks, which encompasses a set of guiding principles, recommended procedures for data collection and analysis, and quantifiable ‘minimal’, ‘expanded’ and ‘optimal' measurement indicators to be tailored to national priorities, capacity and resources.
Abstract: The liberalization of international trade and foreign direct investment through multilateral, regional and bilateral agreements has had profound implications for the structure and nature of food systems, and therefore, for the availability, nutritional quality, accessibility, price and promotion of foods in different locations. Public health attention has only relatively recently turned to the links between trade and investment agreements, diets and health, and there is currently no systematic monitoring of this area. This paper reviews the available evidence on the links between trade agreements, food environments and diets from an obesity and non-communicable disease (NCD) perspective. Based on the key issues identified through the review, the paper outlines an approach for monitoring the potential impact of trade agreements on food environments and obesity/NCD risks. The proposed monitoring approach encompasses a set of guiding principles, recommended procedures for data collection and analysis, and quantifiable 'minimal', 'expanded' and 'optimal' measurement indicators to be tailored to national priorities, capacity and resources. Formal risk assessment processes of existing and evolving trade and investment agreements, which focus on their impacts on food environments will help inform the development of healthy trade policy, strengthen domestic nutrition and health policy space and ultimately protect population nutrition.
97 citations
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TL;DR: The practical application of the MCDA assay was successfully evaluated by detecting the target pathogen nucleic acid in pork samples, which offered advantages on quick results, modest equipment requirements, easiness in operation, and high specificity and sensitivity.
Abstract: Rapid and Sensitive Isothermal Detection of Nucleic-acid Sequence by Multiple Cross Displacement Amplification
97 citations
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TL;DR: The recent research advances related to the antimicrobial activity and toxicity of gold nanoparticles, both in vitro and in vivo, are discussed, and major issues that require further study are identified.
Abstract: Gold nanoparticles are emerging materials that exhibit characteristics distinct from those of traditional materials and that have promising potential for application in the fields of chemistry, physics, biology and medicine. During the past decades, numerous studies on the antimicrobial activity and toxicity of gold nanoparticles have been published. With respect to antimicrobial activity, gold nanoparticles conjugated with small molecules, such as antibiotics, drugs, vaccines and antibodies, are more efficient than individual nanoparticles and molecules. Regarding the toxicity effects, results are often unclear and conflicting because of the lack of a standard experimental method; various studies have used different approaches, administration routes and doses, and similar experiments may lead to different conclusions. To provide a systematic overview of and insight in the current knowledge for researchers committed to this filed, we discuss the recent research advances related to the antimicrobial activity and toxicity of gold nanoparticles, both in vitro and in vivo, and identify major issues that require further study. SIGNIFICANCE AND IMPACT OF THE STUDY: This paper discusses the recent research progress on antimicrobial activity and toxicity of gold nanoparticles and provides general insights into the field for researchers committed to this field.
97 citations
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TL;DR: The finding that tetramer-positive memory CD8+ T cell responses were generated and that CD8- T cells can traffic to a ZikV-infected brain greatly enhances the understanding of ZIKV infection and provides important insights for ZIKv vaccine design.
Abstract: Zika virus (ZIKV) infection causees neurologic complications, including Guillain-Barre syndrome in adults and central nervous system (CNS) abnormalities in fetuses. We investigated the immune response, especially the CD8+ T cell response in C57BL/6 (B6) wild-type (WT) mice, during ZIKV infection. We found that a robust CD8+ T cell response was elicited, major histocompatibility complex class I-restricted CD8+ T cell epitopes were identified, a tetramer that recognizes ZIKV-specific CD8+ T cells was developed, and virus-specific memory CD8+ T cells were generated in these mice. The CD8+ T cells from these infected mice were functional, as evidenced by the fact that the adoptive transfer of ZIKV-specific CD8+ T cells could prevent ZIKV infection in the CNS and was cross protective against dengue virus infection. Our findings provide comprehensive insight into immune responses against ZIKV and further demonstrate that WT mice could be a natural and easy-access model for evaluating immune responses to ZIKV infection.IMPORTANCE ZIKV infection has severe clinical consequences, including Guillain-Barre syndrome in adults, microcephaly, and congenital malformations in fetuses and newborn infants. Therefore, study of the immune response, especially the adaptive immune response to ZIKV infection, is important for understanding diseases caused by ZIKV infection. Here, we characterized the CD8+ T cell immune response to ZIKV in a comprehensive manner and identified ZIKV epitopes. Using the identified immunodominant epitopes, we developed a tetramer that recognizes ZIKV-specific CD8+ T cells in vivo, which simplified the detection and evaluation of ZIKV-specific immune responses. In addition, the finding that tetramer-positive memory CD8+ T cell responses were generated and that CD8+ T cells can traffic to a ZIKV-infected brain greatly enhances our understanding of ZIKV infection and provides important insights for ZIKV vaccine design.
97 citations
Authors
Showing all 16076 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard Peto | 183 | 683 | 231434 |
Barry M. Popkin | 157 | 751 | 90453 |
Jian Yang | 142 | 1818 | 111166 |
Edward C. Holmes | 138 | 824 | 85748 |
Jian Li | 133 | 2863 | 87131 |
Shaobin Wang | 126 | 872 | 52463 |
Elaine Holmes | 119 | 560 | 58975 |
Jian Liu | 117 | 2090 | 73156 |
Sherif R. Zaki | 107 | 417 | 40081 |
Jun Yang | 107 | 2090 | 55257 |
Nan Lin | 105 | 687 | 54545 |
Li Chen | 105 | 1732 | 55996 |
Ming Li | 103 | 1669 | 62672 |
George F. Gao | 102 | 793 | 82219 |
Tao Li | 102 | 2483 | 60947 |