Institution
Chinese Center for Disease Control and Prevention
Government•Beijing, China•
About: Chinese Center for Disease Control and Prevention is a government organization based out in Beijing, China. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 16037 authors who have published 15098 publications receiving 423452 citations. The organization is also known as: China CDC & CCDC.
Topics: Population, Acquired immunodeficiency syndrome (AIDS), Virus, Vaccination, Men who have sex with men
Papers published on a yearly basis
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TL;DR: It is reported that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection, and its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied.
Abstract: The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.
238 citations
Washington University in St. Louis1, Technical University of Madrid2, Beijing Institute of Genomics3, Georgia State University4, United States Army Medical Research Institute of Infectious Diseases5, Commonwealth Scientific and Industrial Research Organisation6, Columbia University7, University of Texas Medical Branch8, Friedrich Loeffler Institute9, National Institutes of Health10, Instituto Biológico11, Albert Einstein College of Medicine12, Erasmus University Rotterdam13, University of Queensland14, University of Marburg15, Humboldt University of Berlin16, Robert Koch Institute17, International Atomic Energy Agency18, University of Pittsburgh19, University of Warwick20, World Health Organization21, Empresa Brasileira de Pesquisa Agropecuária22, Boston University23, Public Health England24, Kyoto University25, Murdoch University26, Huazhong Agricultural University27, University of São Paulo28, Laval University29, Okayama University30, United States Geological Survey31, United States Department of Agriculture32, Northwestern University33, Icahn School of Medicine at Mount Sinai34, Institut de recherche pour le développement35, Ohio State University36, Katholieke Universiteit Leuven37, South Dakota State University38, Novosibirsk State University39, University of Veterinary Medicine Vienna40, University of Medicine and Health Sciences41, University of Bergen42, Texas A&M University43, Queen's University Belfast44, Centers for Disease Control and Prevention45, University of Sydney46, University of Oxford47, Defence Science and Technology Laboratory48, Queensland University of Technology49, Colorado State University50, Hokkaido University51, Pasteur Institute52, National University of Singapore53, North Carolina State University54, Universidade Federal de Viçosa55, Chinese Center for Disease Control and Prevention56, Fudan University57
TL;DR: The updated taxonomy of the order Mononegavirales is presented as now accepted by the International Committee on Taxonomy of Viruses (ICTV).
Abstract: In February 2019, following the annual taxon ratification vote, the order Mononegavirales was amended by the addition of four new subfamilies and 12 new genera and the creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).
238 citations
Pennsylvania State University1, University of California, Irvine2, Chongqing Normal University3, China Medical University (PRC)4, Southern Medical University5, Bengbu Medical College6, Chulalongkorn University7, National Institutes of Health8, Kunming Medical University9, China Agricultural University10, Chinese Center for Disease Control and Prevention11
TL;DR: The changing malaria epidemiology in the GMS is reviewed, the vector systems and patterns of malaria transmission are analyzed, and the major challenges the malaria control community faces on its way to malaria elimination are identified.
237 citations
TL;DR: The program to implement HAART for HIV infection in 1 developing country was associated with a reduction in mortality, but immunologic failure was common in the setting of a limited range of HAART regimens.
Abstract: BACKGROUND: Chinas National Free Antiretroviral Treatment Program began in 2002 and by August 2008 included more than 52 000 patients. OBJECTIVE: To report 5-year outcomes on adult mortality and immunologic treatment failure rates and risk factors. DESIGN: Open cohort analysis of a prospectively collected observational database. SETTING: China. PATIENTS: All patients in the national treatment database from June 2002 to August 2008. Patients were excluded if they had not started triple therapy or had missing treatment regimen information. INTERVENTION: Antiretroviral therapy according to Chinese national treatment guidelines. MEASUREMENTS: Mortality rate and immunologic treatment failure rate according to World Health Organization criteria. RESULTS: Of 52 191 patients 48 785 were included. Median age was 38 years 58% were men 53% were infected through plasma or blood and the median baseline CD4 cell count was 0.118x10(9) cells/L. Mortality was greatest during the first 3 months of treatment (22.6 deaths per 100 person-years) but decreased to a steady rate of 4 to 5 deaths per 100 person-years after 6 months and maintained this rate over the subsequent 4.5 years. The strongest mortality risk factors were a baseline CD4 cell count less than 0.050x10(9) cells/L (adjusted hazard ratio [HR] compared with a count>or=0.200x10(9) cells/L 3.3 [95% CI 2.9 to 3.8]) and having 4 to 5 baseline symptom categories (adjusted HR compared with no baseline symptom categories 3.4 [CI 2.9 to 4.0]). Treatment failure was determined among 31 070 patients with 1 or more follow-up CD4 cell counts. Overall treatment failed for 25% of patients (12.0 treatment failures per 100 person-years) with the cumulative treatment failure rate increasing to 50% at 5 years. Limitation: Immunologic treatment failure does not necessarily correlate well with virologic treatment failure. CONCLUSION: The National Free Antiretroviral Treatment Program reduced mortality among adult patients in China with AIDS to rates similar to those of other low- or middle-income countries. A cumulative immunologic treatment failure rate of 50% after 5 years due to the limited availability of second-line regimens is of great concern.
237 citations
Centers for Disease Control and Prevention1, United States Department of Agriculture2, University of Naples Federico II3, University of Ljubljana4, Mississippi State University5, University of Texas Medical Branch6, Friedrich Loeffler Institute7, Colorado State University8, Columbia University9, University of California, Irvine10, University of the Free State11, Xinjiang University12, Aix-Marseille University13, International Rice Research Institute14, Scripps Research Institute15, Public Health Agency of Canada16, Mayo Clinic17, Hacettepe University18, United States Army Medical Research Institute of Infectious Diseases19, Chinese Center for Disease Control and Prevention20, Kansas State University21, Bernhard Nocht Institute for Tropical Medicine22, Paris Diderot University23, University of Queensland24, University of Helsinki25, University of Zurich26, Public Health England27, Seoul National University28, Charité29, Slovak Academy of Sciences30, Karolinska Institutet31, Katholieke Universiteit Leuven32, University of Washington33, Wuhan University of Science and Technology34, University of Louisville35, University of São Paulo36, University of Bari37, Hokkaido University38, University of Hamburg39, Public Health Agency of Sweden40, Washington State University41, Aristotle University of Thessaloniki42, Oswaldo Cruz Foundation43, University of Brasília44, National University of La Plata45, Pasteur Institute46, University of Maryland, Baltimore47, National Agriculture and Food Research Organization48, University of Glasgow49, University of Tokyo50, University of Oxford51, Korea University52, National Research Council53, Fujian Agriculture and Forestry University54, North Carolina State University55, Universidade Federal de Viçosa56, Fudan University57, National Institutes of Health58
TL;DR: The updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV) is presented.
Abstract: In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV).
237 citations
Authors
Showing all 16076 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Richard Peto | 183 | 683 | 231434 |
| Barry M. Popkin | 157 | 751 | 90453 |
| Jian Yang | 142 | 1818 | 111166 |
| Edward C. Holmes | 138 | 824 | 85748 |
| Jian Li | 133 | 2863 | 87131 |
| Shaobin Wang | 126 | 872 | 52463 |
| Elaine Holmes | 119 | 560 | 58975 |
| Jian Liu | 117 | 2090 | 73156 |
| Sherif R. Zaki | 107 | 417 | 40081 |
| Jun Yang | 107 | 2090 | 55257 |
| Nan Lin | 105 | 687 | 54545 |
| Li Chen | 105 | 1732 | 55996 |
| Ming Li | 103 | 1669 | 62672 |
| George F. Gao | 102 | 793 | 82219 |
| Tao Li | 102 | 2483 | 60947 |