scispace - formally typeset
Search or ask a question
Institution

Chinese Center for Disease Control and Prevention

GovernmentBeijing, China
About: Chinese Center for Disease Control and Prevention is a government organization based out in Beijing, China. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 16037 authors who have published 15098 publications receiving 423452 citations. The organization is also known as: China CDC & CCDC.


Papers
More filters
Journal ArticleDOI
TL;DR: Robust evidence of higher nonaccidental and cardiovascular mortality in association with short-term exposure to ambient ozone in China is provided, and associations between ozone and daily cause-specific mortality were positive but imprecise and nonsignificant.
Abstract: Background: Few large multicity studies have been conducted in developing countries to address the acute health effects of atmospheric ozone pollution. Objective: We explored the associations betwe...

211 citations

Journal ArticleDOI
TL;DR: It is suggested that green tea and curcumin had inhibitory effects against oral carcinogenesis at the post-initiation stage and such inhibition may be related to the suppression of cell proliferation, induction of apoptosis and inhibition of angiogenesis.
Abstract: Tea is one of the most popular beverages consumed in the world. Curcumin, the major yellow pigment in turmeric, is used widely as a spice and food-coloring agent. In this study, we studied the effects of tea and curcumin on 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters. DMBA solution (0.5% in mineral oil, 0.1 ml) was applied topically to the left cheek pouch of male Syrian golden hamsters 3 times/week for 6 weeks. Two days after the last treatment of DMBA, the animals received green tea (6 mg tea solids/ml) as drinking fluid, or 10 mmol curcumin applied topically 3 times/week, or the combination of green tea and curcumin treatment, or no treatment for 18 weeks. The combination of tea and curcumin significantly decreased the oral visible tumor incidence from 92.3% (24/26) to 69.2% (18/26) and the squamous cell carcinoma (SCC) incidence from 76.9% (20/26) to 42.3% (11/26). The combination of tea and curcumin also decreased the number of visible tumors and the tumor volume by 52.4 and 69.8%, as well as the numbers of SCC, dysplasic lesions and papillomas by 62.0, 37.5 and 48.7%, respectively. Green tea or curcumin treatment decreased the number of visible tumors by 35.1 or 39.6%, the tumor volume by 41.6 or 61.3% and the number of SCC by 53.3 or 51.3%, respectively. Green tea also decreased the number of dysplasic lesions. Curcumin also significantly decreased the SCC incidence. Tea and curcumin, singly or in combination, decreased the proliferation index in hyperplasia, dysplasia and papillomas. Only the combination treatment decreased the proliferation index in SCC. Tea alone and in combination with curcumin significantly increased the apoptotic index in dysplasia and SCC. Curcumin, alone and in combination with tea, significantly inhibited the angiogenesis in papilloma and SCC. The results suggested that green tea and curcumin had inhibitory effects against oral carcinogenesis at the post-initiation stage and such inhibition may be related to the suppression of cell proliferation, induction of apoptosis and inhibition of angiogenesis.

211 citations

Journal ArticleDOI
TL;DR: Authors: Richard G. A. Feachem, Ingrid Chen*, Omar Akbari‡, Amelia Bertozzi-Villa, Samir Bhatt, Fred Binka, Maciej Boni, Caroline Buckee, Joseph Dieleman, Arjen Dondorp, Neelam Sekhri FeAChem, Scott Filler, Peter Gething, Roly Gosling, Annie Haakenstad.

209 citations

Journal ArticleDOI
TL;DR: This research highlights the need to understand more fully the role of “spatially aggregated immune checkpoints” in the development of central nervous systems.
Abstract: Drug resistance surveillance is crucial for control of drug-resistant tuberculosis (TB). However, limited data exists on the burden of drug-resistant TB in children. The goal of this work was to generate prevalence data regarding rifampicin- (RIF-) resistant childhood TB in northern China and to test the feasibility of Xpert for surveying pediatric TB drug resistance prevalence. We enrolled 362 clinically diagnosed childhood TB patients and collected sputum, gastric lavage aspirate (GLA), bronchoalveolar lavage fluid (BALF), and cerebral spinal fluid (CSF) samples. Xpert and solid culture were utilized to detect RIF resistance. The detection rate of Xpert-positive TB among new clinically diagnosed TB cases was 38.4% (139/362), significantly higher than that of solid culture-positive TB (16.3%, 59/362, P < 0.01). Notably, Xpert-positive rates differed significantly by sample type, with the highest positive rate for GLA (51.2%). The unit testing costs per RIF-resistant TB patient were $828.41 for solid culture and $761.86 for Xpert. Our data demonstrate that the prevalence of RIF resistance among childhood TB cases in our study (6.9%) is comparable to the national RIF resistance prevalence level of new cases (6.7%). In addition, Xpert is superior to the solid culture for RIF resistance survey in the childhood TB patients.

208 citations

Journal ArticleDOI
TL;DR: Of the estimated 200 million infected people, more than half haveSchistosomiasis is a chronic and debilitating disease that is caused by parasitic trematode worms (schistosomes).
Abstract: Schistosomiasis is a chronic and debilitating disease that is caused by parasitic trematode worms (schistosomes). It continues to threaten millions of people, particularly the rural poor in the developing world ([11][1], [24][2]). Of the estimated 200 million infected people, more than half have

208 citations


Authors

Showing all 16076 results

NameH-indexPapersCitations
Richard Peto183683231434
Barry M. Popkin15775190453
Jian Yang1421818111166
Edward C. Holmes13882485748
Jian Li133286387131
Shaobin Wang12687252463
Elaine Holmes11956058975
Jian Liu117209073156
Sherif R. Zaki10741740081
Jun Yang107209055257
Nan Lin10568754545
Li Chen105173255996
Ming Li103166962672
George F. Gao10279382219
Tao Li102248360947
Network Information
Related Institutions (5)
Centers for Disease Control and Prevention
82.5K papers, 4.4M citations

93% related

Peking Union Medical College
61.8K papers, 1.1M citations

89% related

Nanjing Medical University
37.9K papers, 635.8K citations

88% related

Capital Medical University
47.2K papers, 811.2K citations

86% related

Peking University
181K papers, 4.1M citations

86% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20235
202283
20211,490
20201,678
20191,244
20181,041