Showing papers by "Chinese PLA General Hospital published in 1994"

Preliminary report of clinical application of hematoporphyrin monomethyl ether in photodynamic therapy for alimentary cancers

Abstract: A new sensitizer, hematoporphyrin monomethyl ether (HMME), purified by the Second Military Medical University was used with a gold vapor laser for PDT in 8 cases of alimentary cancers. The results showed that 2 cases of early stage gastric cancer and 1 case of rectal polyps with malignancy revealed CR, SR was obtained in 1 case of esophageal cancer and 4 others were MR. No sunburn occurred within the 8 patients who received 12 doses of HMME at 5 mg/kg 2 - 3 hours prior to laser treatment and who were kept away from sun light only 6 hours. Hematoporphyrin monomethyl ether is an effective single compound and safer for PDT.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

Polymorphisms of apolipoprotein B gene in relation to coronary heart disease in Chinese Han nationality.

Abstract: Two polymorphic sites of apolipoprotein B (apoB) gene, XbaI and EcoRI, were examined in 80 patients with documented coronary heart disease (CHD) and 60 healthy individuals selected from a population of Chinese Han nationality. Allele frequencies at these sites were compared between the patients and controls and their impact on lipid metabolism was also investigated. The frequency of X+ allele (presence of XbaI cutting site) in CHD patients was 0.10, which was significantly higher than 0.01 in controls (P 0.05). There was no relationship between XbaI RFLP and EcoRI RFLP. In the CHD patients, X+ allele was associated with the lower levels of HDL-C and apoAI when compared with X- allele, while no associations were found of X+ allele with other lipid parameters. On the contrary, the EcoRI polymorphism had no significant influence on plasma lipid and lipoprotein levels. Therefore, it was suggested that genetic variation at XbaI site of apoB gene might contribute to the determination of plasma HDL-C level and development of CHD in people among Chinese Han nationality.

A study on the resistance of methicillin resistant Staphylococcus aureus to antimicrobial agents

Abstract: The morbidity of the infections caused by methicillin resistant staphylococcus aureus increased in recent years. In order to know the resistance of MRSA to antimicrobial agents, the minimal inhibitory concentrations (MICs) of antimicrobial agents against S. Aureus isolated from inpatients were measured. The presence of beta-lactamase in and the types of coagulase of the strains tested were determined as well. The results showed that MRSA accounted for 50.7% of the strains tested, the incidence of MRSA producing beta-lactamase was 85.1% and the coagulase of MRSA was all of type II. MRSA showed resistance to most of the lactam antibiotics and some of the aminoglycosides. Vancomycin and arbikacin had the highest activity against MRSA; other effective antibiotics were in the following order: amikacin, minocycline, tosulfloxacin and imipenem. It is suggested that serious infections caused by MRSA may be cured by using vancomycin, arbikacin or other antibiotics mentioned above.

Prolonged lung retention of 131I-HIPDM in smokers.

Abstract: Thirty-five subjects were divided into 4 groups; the first group was composed of 8 healthy nonsmoking subjects; the second group included 8 healthy smokers; the third group included 12 nonsmoking patients suffering from chronic obstructive pulmonary emphysema; the fourth group was composed of 7 smokers with chronic obstructive pulmonary emphysema. N,N,N'-trimethyl-N'2-Hydroxy-3-Methyl-5-iodobenzyl-1,3-propanediamine iodine-131(HIPDM) was rapidly injected into the antecubital vein. The influence of 131I-HIPDM by lung clearance was analysed thought imaging of lung and ratio of prolongation of 131I-HIPDM in the lung. Prolongation of 131I-HIPDM in the lung was shown in the smokers with chronic obstructive pulmonary emphysema in 60 minutes, and the healthy smokers, smokers with chronic obstructive pulmonary emphysema in the 24 hours after the injection of 131I-HIPDM. Smoking is an important factor of disturbance of lung clearance.

A Case of Cancer and Cirrhosis of Liver Effectively Treated with Sho-saiko-to and Cordys sinensis

Abstract: 冬虫夏草, 小柴胡湯が奏効したHB肝炎, 肝不全の1例を報告した。症例は43歳の内科開業医, 10年前, HB肝炎に感染した。肝〓護剤, 強力ミノファゲンCなどで加療していた。2年前より肝機能が悪化し, インターフェロン (IFN) 及び諸治療に抵抗して進行し, 肝不全となったので, 小柴胡湯エキス剤と冬虫夏草 (煎剤) との併用療法を行ってみたところ食欲著明に改善, 肝機能, 特に黄疸 (ビリルビン) など著明改善しており, この併用療法が奏効しているものと思われる。