Showing papers by "Chonbuk National University published in 2014"
Vardan Khachatryan1, Robin Erbacher2, C. A. Carrillo Montoya3, Chang-Seong Moon4 +2123 more•Institutions (138)
TL;DR: In this paper, the diphoton decay mode of the recently discovered Higgs boson and measurement of some of its properties are reported using the entire dataset collected by the CMS experiment in proton-proton collisions during the 2011 and 2012 LHC running periods.
Abstract: Observation of the diphoton decay mode of the recently discovered Higgs boson and measurement of some of its properties are reported. The analysis uses the entire dataset collected by the CMS experiment in proton-proton collisions during the 2011 and 2012 LHC running periods. The data samples correspond to integrated luminosities of 5.1 inverse femtobarns at sqrt(s) = 7 TeV and 19.7 inverse femtobarns at 8 TeV. A clear signal is observed in the diphoton channel at a mass close to 125 GeV with a local significance of 5.7 sigma, where a significance of 5.2 sigma is expected for the standard model Higgs boson. The mass is measured to be 124.70 +/- 0.34 GeV = 124.70 +/- 0.31 (stat) +/- 0.15 (syst) GeV, and the best-fit signal strength relative to the standard model prediction is 1.14 +0.26/-0.23 = 1.14 +/- 0.21 (stat) +0.09/-0.05 (syst) +0.13/-0.09 (theo). Additional measurements include the signal strength modifiers associated with different production mechanisms, and hypothesis tests between spin-0 and spin-2 models.
486 citations
TL;DR: In this article, a detailed review of various strategies to improve the corrosion resistance of microarc oxidation (MAO) coatings on Mg/Mg alloys is presented.
485 citations
TL;DR: Both in vitro and in vivo results indicate that ginseng has potentially positive effects on heart disease through its various properties including antioxidation, reduced platelet adhesion, vasomotor regulation, improving lipid profiles, and influencing various ion channels.
337 citations
TL;DR: Evidence is provided that the adverse health effects of AAP and PM are more pronounced among the elderly, children, and people with preexisting cardiovascular and respiratory conditions, with a particular focus on PM size.
Abstract: Ambient air pollution (AAP) and particulate matters (PM) have been closely associated with adverse health effects such as respiratory disease and cardiovascular diseases. Previous studies have examined the adverse health effects associated with short- and long-term exposure to AAP and outdoor PM on respiratory disease. However, the effect of PM size (PM2.5 and PM10) on cardiovascular disease has not been well studied. Thus, it remains unclear how the size of the inhalable particles (coarse, fine, or ultrafine) affects mortality and morbidity. Airborne PM concentrations are commonly used for ambient air quality management worldwide, owing to the known effects on cardiorespiratory health. In this article, we assess the relationship between cardiovascular diseases and PM, with a particular focus on PM size. We discuss the association of PM2.5 and PM10, nitrogen dioxide (NO2), and elemental carbon with mortality and morbidity due to cardiovascular diseases, stroke, and altered blood pressure, based on epidemiological studies. In addition, we provide evidence that the adverse health effects of AAP and PM are more pronounced among the elderly, children, and people with preexisting cardiovascular and respiratory conditions. Finally, we critically summarize the literature pertaining to cardiovascular diseases, including atherosclerosis and stroke, and introduce potential studies to better understand the health significance of AAP and PM on cardiovascular disease.
333 citations
Proceedings Article•
31 Jul 2014
288 citations
TL;DR: The activity of different UPRs involved in tumorigenesis and resistance to cancer therapy are described, which seems to adjust the paradoxical microenvironment of cancer and is one of resistance mechanisms against cancer therapy.
Abstract: The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress and cancer, and particularly the involvement of the UPR. The UPR seems to adjust the paradoxical microenvironment of cancer and, as such, is one of resistance mechanisms against cancer therapy. This review describes the activity of different UPRs involved in tumorigenesis and resistance to cancer therapy.
277 citations
TL;DR: PU-CA-zein-drug composite nanoscaffold showed enhanced blood clotting ability in comparison with pristine PU nanofibers, and the presence of CA and zein in the nanofiber membrane improved its hydrophilicity, bioactivity and created a moist environment for the wound, which can accelerate wound recovery.
277 citations
University of Potsdam1, VU University Amsterdam2, Technical University of Denmark3, Deutscher Wetterdienst4, University of Toronto5, Vienna University of Technology6, Sapienza University of Rome7, Braunschweig University of Technology8, Maynooth University9, University of Arizona10, Newcastle University11, Munich Re12, Chonbuk National University13, Columbia University14, Helmholtz Centre for Environmental Research - UFZ15, Free University of Berlin16, University of Freiburg17, University of Savoy18
TL;DR: In this paper, the authors contrast traditional views with broader perspectives that are emerging from an improved understanding of the climatic context of floods, and they come to the following conclusions: (1) extending the traditional system boundaries (local catchment, recent decades, hydrological/hydraulic processes) opens up exciting possibilities for better understanding and improved tools for flood risk assessment and management.
Abstract: Flood estimation and flood management have traditionally been the domain of hydrologists, water resources engineers and statisticians, and disciplinary approaches abound. Dominant views have been shaped; one example is the catchment perspective: floods are formed and influenced by the interaction of local, catchment-specific characteristics, such as meteorology, topography and geology. These traditional views have been beneficial, but they have a narrow framing. In this paper we contrast traditional views with broader perspectives that are emerging from an improved understanding of the climatic context of floods. We come to the following conclusions: (1) extending the traditional system boundaries (local catchment, recent decades, hydrological/hydraulic processes) opens up exciting possibilities for better understanding and improved tools for flood risk assessment and management. (2) Statistical approaches in flood estimation need to be complemented by the search for the causal mechanisms and dominant processes in the atmosphere, catchment and river system that leave their fingerprints on flood characteristics. (3) Natural climate variability leads to time-varying flood characteristics, and this variation may be partially quantifiable and predictable, with the perspective of dynamic, climate-informed flood risk management. (4) Efforts are needed to fully account for factors that contribute to changes in all three risk components (hazard, exposure, vulnerability) and to better understand the interactions between society and floods. (5) Given the global scale and societal importance, we call for the organization of an international multidisciplinary collaboration and data-sharing initiative to further understand the links between climate and flooding and to advance flood research.
273 citations
University of Ulsan1, Chungnam National University2, Korea University3, Chonnam National University4, Yonsei University5, Keimyung University6, Catholic University of Korea7, Soonchunhyang University8, Hallym University9, Kangwon National University10, Catholic University of Daegu11, Chonbuk National University12, Kyungpook National University13, Dongguk University14, Inje University15
TL;DR: An additional 24 months of dual antiplatelet therapy versus aspirin alone did not reduce the risk of the composite end point of death from cardiac causes, myocardial infarction, or stroke.
Abstract: Background—The risks and benefits of long-term dual antiplatelet therapy remain unclear Methods and Results—This prospective, multicenter, open-label, randomized comparison trial was conducted in 24 clinical centers in Korea In total, 5045 patients who received drug-eluting stents and were free of major adverse cardiovascular events and major bleeding for at least 12 months after stent placement were enrolled between July 2007 and July 2011 Patients were randomized to receive aspirin alone (n=2514) or clopidogrel plus aspirin (n=2531) The primary end point was a composite of death resulting from cardiac causes, myocardial infarction, or stroke 24 months after randomization At 24 months, the primary end point occurred in 57 aspirin-alone group patients (24%) and 61 dual-therapy group patients (26%; hazard ratio, 094; 95% confidence interval, 066–135; P=075) The 2 groups did not differ significantly in terms of the individual risks of death resulting from any cause, myocardial infarction, stent
267 citations
TL;DR: In this article, the effect of different stacking sequences of carbon and basalt fabrics on the flexural properties of hybrid composite laminates was investigated, and it was found that the proper stacking sequence of basalt and carbon fiber layers was found to improve the balance of the mechanical properties of the hybrid composite laminate.
Abstract: We investigated the effect of different stacking sequences of carbon and basalt fabrics on the flexural properties of hybrid composite laminates. The hybrid composites were fabricated using a vacuum-assisted resin transfer molding process. Three-point bending test was performed and the fracture surfaces were examined by scanning electron microscopy. The present results showed that the flexural strength and modulus of hybrid composite laminates were strongly dependent on the sequence of fiber reinforcement. All the stacking sequences showed a positive hybridization effect. The interply hybrid composite with carbon fiber at the compressive side exhibited higher flexural strength and modulus than when basalt fabric was placed at the compressive side. Here, the proper stacking sequence of basalt and carbon fiber layers was found to improve the balance of the mechanical properties of the hybrid composite laminate.
256 citations
TL;DR: The study showed that treatment with NPs is notably effective against the proliferation of HepG2 and MCF-7 cancer cells in a dose-dependent manner, and upregulation of the mRNA expression level of Bax, p53, and caspase-3 and the down regulation of the anti-apoptotic gene Bcl-2 is demonstrated.
Vardan Khachatryan1, Robin Erbacher2, C. A. Carrillo Montoya3, Chang-Seong Moon4 +2186 more•Institutions (146)
TL;DR: A search for neutral Higgs bosons in the minimal supersymmetric extension of the standard model (MSSM) decaying to tau-lepton pairs in pp collisions is performed, using events recorded by the CMS experiment at the LHC.
Abstract: A search for neutral Higgs bosons in the minimal supersymmetric extension of the standard model (MSSM) decaying to tau-lepton pairs in pp collisions is performed, using events recorded by the CMS experiment at the LHC. The dataset corresponds to an integrated luminosity of 24.6 fb^(−1), with 4.9 fb^(−1) at 7 TeV and 19.7 fb^(−1) at 8 TeV. To enhance the sensitivity to neutral MSSM Higgs bosons, the search includes the case where the Higgs boson is produced in association with a b-quark jet. No excess is observed in the tau-lepton-pair invariant mass spectrum. Exclusion limits are presented in the MSSM parameter space for different benchmark scenarios, m_h^(max), m_h^(mod)_ +, m_h^(mod)_ -, light-stop, light-stau, τ-phobic, and low-m_H. Upper limits on the cross section times branching fraction for gluon fusion and b-quark associated Higgs boson production are also given.
Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2194 more•Institutions (180)
TL;DR: In this article, a search for the standard model Higgs boson produced in association with a top-quark pair (ttH) is presented, using data samples corresponding to integrated luminosities of up to 5.1 fb^(−1) and 19.7 fb+1, collected in pp collisions at center of mass energies of 7 TeV and 8 TeV respectively.
Abstract: A search for the standard model Higgs boson produced in association with a top-quark pair (ttH) is presented, using data samples corresponding to integrated luminosities of up to 5.1 fb^(−1) and 19.7 fb^(−1) collected in pp collisions at center-of-mass energies of 7 TeV and 8 TeV respectively. The search is based on the following signatures of the Higgs boson decay: H → hadrons, H → photons, and H → leptons. The results are characterized by an observed ttH signal strength relative to the standard model cross section, μ=σ/σ SM,under the assumption that the Higgs boson decays as expected in the standard model. The best fit value is μ = 2.8 ± 1.0 for a Higgs boson mass of 125.6 GeV.
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam +2124 more•Institutions (141)
TL;DR: A search for heavy, right-handed neutrinos in the left-right symmetric extensions of the standard model was performed by the CMS experiment as discussed by the authors, and the search was based on a sample of two lepton plus two jet events collected in proton-proton collisions at a center-of-mass energy of 8.7 �
Abstract: A search for heavy, right-handed neutrinos, $$\mathrm {N}_{\ell }$$
(
$$\ell = \mathrm {e}, \mu $$
), and right-handed $$\mathrm {W}_{\mathrm {R}}$$
bosons, which arise in the left-right symmetric extensions of the standard model, has been performed by the CMS experiment. The search was based on a sample of two lepton plus two jet events collected in proton–proton collisions at a center-of-mass energy of 8
$$\,\text {TeV}$$
corresponding to an integrated luminosity of 19.7
$$\mathrm{fb}^{-1}$$
. For models with strict left-right symmetry, and assuming only one $$\mathrm {N}_{\ell }$$
flavor contributes significantly to the $$\mathrm {W}_{\mathrm {R}}$$
decay width, the region in the two-dimensional $$(M_{\mathrm {W}_{\mathrm {R}}}, M_{\mathrm {N}_{\ell }})$$
mass plane excluded at a 95 % confidence level extends to approximately $$M_{\mathrm {W}_{\mathrm {R}}} = 3.0\,\text {TeV} $$
and covers a large range of neutrino masses below the $$\mathrm {W}_{\mathrm {R}}$$
boson mass, depending on the value of $$M_{\mathrm {W}_{\mathrm {R}}}$$
. This search significantly extends the $$(M_{\mathrm {W}_{\mathrm {R}}}, M_{\mathrm {N}_{\ell }})$$
exclusion region beyond previous results.
TL;DR: This work discusses and suggests the required specifications of biosorbents for recovery of PMs and strategies to give the required properties to the biosorbent and hopes to give insights into this research frontier.
TL;DR: Despite the relatively weak anti-diabetic and anti-AD potentials, apigenin showed powerful antiinflammatory activity by inhibiting NO production and iNOS and COX-2 expression while vitex in and isovitexin were inactive.
TL;DR: The findings not only provide the fundamental studies on carbon supported low-dimensional transition-metal oxides but also open up the new possibilities of their applications in green energy devices.
TL;DR: The synthesized AgNPs showed a moderate antibacterial activity against bacterial food pathogens and the nanocrystalline phase of Ag and Au with FCC crystal structures have been confirmed by X-ray diffraction analysis.
Abstract: In the present study, we synthesized silver and gold nanoparticles with a particle size of 10–20 nm, using Zingiber officinale root extract as a reducing and capping agent. Chloroauric acid (HAuCl4) and silver nitrate (AgNO3) were mixed with Z. officinale root extract for the production of silver (AgNPs) and gold nanoparticles (AuNPs). The surface plasmon absorbance spectra of AgNPs and AuNPs were observed at 436–531 nm, respectively. Optimum nanoparticle production was achieved at pH 8 and 9, 1 mM metal ion, a reaction temperature 50 °C and reaction time of 150–180 min for AgNPs and AuNPs, respectively. An energy-dispersive X-ray spectroscopy (SEM–EDS) study provides proof for the purity of AgNPs and AuNPs. Transmission electron microscopy images show the diameter of well-dispersed AgNPs (10–20 nm) and AuNPs (5–20 nm). The nanocrystalline phase of Ag and Au with FCC crystal structures have been confirmed by X-ray diffraction analysis. Fourier transform infrared spectroscopy analysis shows the respective peaks for the potential biomolecules in the ginger rhizome extract, which are responsible for the reduction in metal ions and synthesized AgNPs and AuNPs. In addition, the synthesized AgNPs showed a moderate antibacterial activity against bacterial food pathogens.
Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2201 more•Institutions (180)
TL;DR: In this article, the authors presented an analysis on the total width of the recently discovered Higgs boson, Gamma[H], using its relative on-shell and off-shell production and decay rates to a pair of Z bosons, where one Z boson decays to an electron or muon pair, and the other to a neutrino pair.
TL;DR: This work identifies an HR-defect (HRD) gene signature, which can be used to functionally assess HR repair status without interrogating individual genetic alterations in cells, and which is able to predict clinical outcomes across multiple cancer lineages.
Abstract: Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA-damage-inducing therapeutics. Here we identify an HR-defect (HRD) gene signature, which can be used to functionally assess HR repair status without interrogating individual genetic alterations in cells. By using this HRD gene signature as a functional network analysis tool, we discover that simultaneous loss of two major tumor suppressors BRCA1 and PTEN extensively rewire the HR repair-deficient phenotype, which is found in cells with defects in either BRCA1 or PTEN alone. Moreover, the HRD gene signature serves as an effective drug discovery platform to identify agents targeting HR repair as potential chemo/radio-sensitizers. More importantly, this HRD gene signature is able to predict clinical outcomes across multiple cancer lineages. Our findings, therefore, provide a molecular profile of HR repair to assess its status at a functional network level, which can provide both biological insights and have clinical implications in cancer.
TL;DR: Since the NiCo₂O₄-RGO composite shows a highly stable response during methanol oxidation reaction, it is a very promising material to be used as an electrocatalyst in the development of high performance non-Pt based alkaline fuel cells.
Abstract: The design and development of cheap, highly active, and durable non-platinum (Pt)-based electrocatalysts for methanol electrooxidation is highly desirable, but is a challenging task. In this paper, we demonstrate the application of a hydrothermally synthesized NiCo2O4–reduced graphene oxide (RGO) composite as an electrocatalyst for the electrochemical oxidation of methanol in alkaline pH. The physicochemical properties of the NiCo2O4–RGO composite were investigated via Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Raman spectroscopy (RS), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) measurements. The physical characterization methods confirm the deposition of NiCo2O4 nanoparticles on the RGO surface. The TEM image shows that the NiCo2O4 nanoparticles with an average size of ∼10 nm are distributed over the RGO surface. Compared to RGO and NiCo2O4 nanoparticles, the NiCo2O4–RGO-based electrode shows excellent electrocatalytic activity for the oxidation of methanol in alkaline pH. On the NiCo2O4–RGO-based electrode, the oxidation of methanol occurs at ∼0.6 V with a higher catalytic current density, and the response is highly stable. The excellent electrocatalytic activity of the NiCo2O4–RGO composite is attributed to the synergistic effects between the NiCo2O4 nanoparticles and RGO. Since the NiCo2O4–RGO composite shows a highly stable response during methanol oxidation reaction, it is a very promising material to be used as an electrocatalyst in the development of high performance non-Pt based alkaline fuel cells.
TL;DR: In this paper, Nitrogen (N)-doped graphene (NG) sheets were prepared using (NH4)2CO3 and an aqueous dispersion of graphene oxide (GO) by an eco-friendly hydrothermal reaction.
TL;DR: Enterobacter sp.
Abstract: Microbiota in the niches of the rhizosphere zones can affect plant growth and responses to environmental stress conditions via mutualistic interactions with host plants. Specifically, some beneficial bacteria, collectively referred to as Plant Growth Promoting Rhizobacteria (PGPRs), increase plant biomass and innate immunity potential. Here, we report that Enterobacter sp. EJ01, a bacterium isolated from sea china pink (Dianthus japonicus thunb) in reclaimed land of Gyehwa-do in Korea, improved the vegetative growth and alleviated salt stress in tomato and Arabidopsis. EJ01 was capable of producing 1-aminocy-clopropane-1-carboxylate (ACC) deaminase and also exhibited indole-3-acetic acid (IAA) production. The isolate EJ01 conferred increases in fresh weight, dry weight, and plant height of tomato and Arabidopsis under both normal and high salinity conditions. At the molecular level, short-term treatment with EJ01 increased the expression of salt stress responsive genes such as DREB2b, RD29A, RD29B, and RAB18 in Arabidopsis. The expression of proline biosynthetic genes (i.e. P5CS1 and P5CS2) and of genes related to priming processes (i.e. MPK3 and MPK6) were also up-regulated. In addition, reactive oxygen species scavenging activities were enhanced in tomatoes treated with EJ01 in stressed conditions. GFP-tagged EJ01 displayed colonization in the rhizosphere and endosphere in the roots of Arabidopsis. In conclusion, the newly isolated Enterobacter sp. EJ01 is a likely PGPR and alleviates salt stress in host plants through multiple mechanisms, including the rapid up-regulation of conserved plant salt stress responsive signaling pathways.
TL;DR: It is suggested that mitochondrial ROS have a critical role in the pathogenesis of allergic airway inflammation through the modulation of NLRP3 inflammasome activation, providing a novel role of airway epithelial cells expressing NLRP2 inflammaome as an immune responder.
Abstract: NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation
TL;DR: In this article, a novel strategy for rapid transformation of graphite into graphene-intercalated with nanostructure MnO 2 with morphology control is introduced by one-pot reaction, low-time consuming and eco-environmentally method.
TL;DR: Combination of these techniques indicated that iron oxides and the weathering products of sulfide minerals played an important role in regulating the arsenic retention in the soils.
TL;DR: It is suggested that the tDCS-induced changes in the bilateral prefrontal excitability during computer-assisted cognitive training may have beneficial effects on age-related cognitive decrement in healthy older adults.
Abstract: The aim of the present study was to analyze the long-term effects of transcranial direct current stimulation (tDCS) of the bilateral prefrontal cortex combined with computer-assisted cognitive training on working memory and cognitive function in healthy older adults aged at least 65 years. Forty healthy older adults were enrolled and randomly assigned to two groups: anodal and sham tDCS. All participants completed 10 sessions of computer-assisted cognitive training, combined with tDCS of the bilateral prefrontal cortex. The accuracy of the verbal working memory task and performance of the digit span forward test were significantly improved after computer-assisted cognitive training combined with bifrontal anodal tDCS as compared with that after computer-assisted cognitive training combined with sham tDCS. Moreover, the effect lasts for 4 weeks in the verbal working memory task. We suggest that the tDCS-induced changes in the bilateral prefrontal excitability during computer-assisted cognitive training may have beneficial effects on age-related cognitive decrement in healthy older adults.
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam +2199 more•Institutions (174)
TL;DR: In this article, an algorithm is defined to identify single-jet objects that originate from the merging of the decay products of W bosons produced with high transverse momenta from jets initiated by single partons.
Abstract: In searches for new physics in the energy regime of the LHC, it is becoming increasingly important to distinguish single-jet objects that originate from the merging of the decay products of W bosons produced with high transverse momenta from jets initiated by single partons. Algorithms are defined to identify such W jets for different signals of interest, using techniques that are also applicable to other decays of bosons to hadrons that result in a single jet, such as those from highly boosted Z and Higgs bosons. The efficiency for tagging W jets is measured in data collected with the CMS detector at a center-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 19.7 inverse femtobarns. The performance of W tagging in data is compared with predictions from several Monte Carlo simulators.
TL;DR: In this article, an effective method for depositing highly transparent and conductive ultrathin silver (Ag) electrodes using minimal oxidation is reported, which signifi cantly improves the intrinsic optical and structural properties of Ag without any degradation of its electrical conductivity.
Abstract: An effective method for depositing highly transparent and conductive ultrathin silver (Ag) electrodes using minimal oxidation is reported. The minimal oxidation of Ag layers signifi cantly improves the intrinsic optical and structural properties of Ag without any degradation of its electrical conductivity. Oxygen-doped Ag (AgO x ) layers of thicknesses as low as 6 nm exhibit completely 2D and continuous morphologies on ZnO fi lms, smaller optical refl ections and absorbances, and smaller sheet resistances compared with those of discontinuous and granular-type Ag layers of the same thickness. A ZnO/AgO x /ZnO (ZAOZ) electrode using an AgO x (O/Ag = 3.4 at%) layer deposited on polyethylene terephthalate substrates at room temperature shows an average transmittance of 91%, with a maximum transmittance of 95%, over spectral range 4001000 nm and a sheet resistance of 20 Ω sq 1 . The average transmittance value is increased by about 18% on replacing a conventional ZnO/Ag/ZnO (ZAZ) electrode with the ZAOZ electrode. The ZAOZ electrode is a promising bottom transparent conducting electrode for highly fl exible inverted organic solar cells (IOSCs), and it achieves a power conversion effi ciency (PCE) of 6.34%, whereas an IOSC using the ZAZ electrode exhibits a much lower PCE of 5.65%.
TL;DR: In this article, machine learning algorithms based on Artificial Neural Networks (ANNs) including an Auto-Associative Neural Network (AANN) based on a standard ANN form and a novel approach to auto-association with Radial Basis Functions (RBFs) networks are used, which are optimised for fast and efficient runs.