Chonbuk National University

About: Chonbuk National University is a education organization based out in Jeonju, South Korea. It is known for research contribution in the topics: Apoptosis & Graphene. The organization has 14820 authors who have published 28884 publications receiving 554131 citations.

Cartoon distraction alleviates anxiety in children during induction of anesthesia.

Abstract: Background We performed this study to determine the beneficial effects of viewing an animated cartoon and playing with a favorite toy on preoperative anxiety in children aged 3 to 7 years in the operating room before anesthesia induction. Methods One hundred thirty children aged 3 to 7 years with ASA physical status I or II were enrolled. Subjects were randomly assigned to 1 of 3 groups: group 1 (control), group 2 (toy), and group 3 (animated cartoon). The children in group 2 were asked to bring their favorite toy and were allowed to play with it until anesthesia induction. The children in group 3 watched their selected animated cartoon until anesthesia induction. Children's preoperative anxiety was determined by the modified Yale Preoperative Anxiety Scale (mYPAS) and parent-recorded anxiety Visual Analog Scale (VAS) the night before surgery, in the preanesthetic holding room, and just before anesthesia induction. Results In the preanesthetic holding room, the group 2 mYPAS and parent-recorded anxiety VAS scores were significantly lower than those of groups 1 and 3 (mYPAS: P = 0.007; parent-recorded anxiety VAS: P = 0.02). In the operating room, the children in group 3 had the lowest mYPAS and parent-recorded anxiety VAS scores among the 3 groups (mYPAS: P Conclusions Allowing the viewing of animated cartoons by pediatric surgical patients is a very effective method to alleviate preoperative anxiety. Our study suggests that this intervention is an inexpensive, easy to administer, and comprehensive method for anxiety reduction in the pediatric surgical population.

Effects of dual component microcapsules of resin and curing agent on the self-healing efficiency of epoxy

Abstract: Dual component microcapsules of diglycidyl ether of bisphenol A epoxy (DGEBA) (resin) and polyetheramine (hardener) for the self-healing agencies of epoxy were prepared by a water-in-oil-in-water emulsion solvent evaporation technique with the polymethyl methacrylate (PMMA) shell. The chemical structure and morphologies of the microcapsules were confirmed using Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM), respectively. The thermal characteristics of the microcapsules were investigated using thermo-analytical techniques such as differential scanning calorimetric (DSC) and thermogravimetric analysis (TGA). Dual components microcapsules of resin and curing agent were embedded into the epoxy matrix and the healing behavior of the system was studied. About 43.5% healing efficiency was achieved with 5 wt.% microcapsules and 84.5% healing efficiency was achieved with 15 wt.% microcapsules at room temperature for 24 h curing. The healing efficiency of the composite with the dual component microcapsules was higher than that of the composite with the single component healing microcapsule due to the easy reaction between the liquid resin and the liquid hardener at the crack surface. The tensile strength of the epoxy with dual component microcapsules increased initially with increasing the content of microcapsules and reached the maximum at 5 wt.%. Above this point, the tensile strength decreased gradually with increasing.

Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19.

Abstract: The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression of SARS-CoV-2 entry-related host molecules in all nasal epithelial cells, we show that the protein levels are relatively high and that their localizations are restricted to the apical side of multiciliated epithelial cells. In addition, we provide evidence in patients with COVID-19 that SARS-CoV-2 is massively detected and replicated within the multiciliated cells. We observed these findings during the early stage of COVID-19, when infected ciliated cells were rapidly replaced by differentiating precursor cells. Moreover, our analyses revealed that SARS-CoV-2 cellular tropism was restricted to the nasal ciliated versus oral squamous epithelium. These results imply that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 could be an ideal strategy to prevent SARS-CoV-2 propagation.

Biomediated Silver Nanoparticles for the Highly Selective Copper(II) Ion Sensor Applications

Abstract: Nanoparticles synthesis is an evergreen research field of 21st century in which the connotation of the biomediated experimental process is highly imperative. Biomediated silver nanoparticles were synthesized with the aid of an eco-friendly biomaterial, namely, aqueous Azadirachta indica extract. The effect of pH and temperature on the formation of silver nanoparticles was analyzed. Formation of the silver nanoparticles was verified by surface plasmon spectra using a UV–vis spectrophotometer. Morphology and crystalline structure of the prepared silver nanoparticles were characterized by TEM and XRD techniques, respectively. Furthermore, the biomediated silver nanoparticles without any surface modification were used for the heavy metal ion sensors in aqueous media. The prepared silver nanoparticles were successful in detecting even the minimal amount of heavy metal copper(II) ion and exhibited excellent specific metal ion selectivity.

Intrathecal injection of the ς1 receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain

Abstract: Supported by grant No. M103KV010015-08K2201-01510 from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Seoul, Republic of Korea, and grant No. R01-2005-000-10580-0 from the Basic Research Program of the Korea Science and Engineering Foundation, Daejeon, Republic of Korea.