Institution
Chonbuk National University
Education•Jeonju, South Korea•
About: Chonbuk National University is a education organization based out in Jeonju, South Korea. It is known for research contribution in the topics: Apoptosis & Nanofiber. The organization has 14820 authors who have published 28884 publications receiving 554131 citations.
Topics: Apoptosis, Nanofiber, Population, Graphene, Electrospinning
Papers published on a yearly basis
Papers
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Vardan Khachatryan1, Robin Erbacher2, C. A. Carrillo Montoya3, Wagner Carvalho4 +2303 more•Institutions (174)
TL;DR: In this paper, the authors describe the algorithms used by the CMS experiment to reconstruct and identify tau to hadrons + tau neutrino decays during Run 1 of the LHC.
Abstract: This paper describes the algorithms used by the CMS experiment to reconstruct and identify tau to hadrons + tau neutrino decays during Run 1 of the LHC. The performance of the algorithms is studied in proton-proton collisions recorded at a centre-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 19.7 inverse femtobarns. The algorithms achieve an identification efficiency of 50-60%, with misidentification rates for quark and gluon jets, electrons, and muons between per mille and per cent levels.
112 citations
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University of Chicago1, University of Ulsan2, Washington University in St. Louis3, Duke University4, Seoul National University Bundang Hospital5, National University of Singapore6, Brigham and Women's Hospital7, Samsung Medical Center8, Yale University9, Korea University10, Johns Hopkins University11, Baylor University Medical Center12, Juravinski Cancer Centre13, Kyungpook National University14, Sarah Cannon Research Institute15, McGill University Health Centre16, Gachon University17, Chonbuk National University18, Taipei Veterans General Hospital19, Georgetown University20, Mayo Clinic21, New Generation University College22
TL;DR: These findings serve as proof of concept of synergistic antitumour activity with the combination of an Fc-optimised anti-HER2 agent (margetuximab) along with anti-PD-1 checkpoint blockade (pembrolizumab).
Abstract: Summary Background Margetuximab, a novel, investigational, Fc-engineered, anti-HER2 monoclonal antibody, is designed to more effectively potentiate innate immunity than trastuzumab. We aimed to evaluate the safety, tolerability, and antitumour activity of margetuximab plus pembrolizumab (an anti-PD-1 monoclonal antibody) in previously treated patients with HER2-positive gastro-oesophageal adenocarcinoma. Methods CP-MGAH22–05 was a single-arm, open-label, phase 1b–2 dose-escalation and cohort expansion study done at 11 academic centres in the USA and Canada and 15 centres in southeast Asia (Korea, Taiwan, and Singapore) that enrolled men and women aged 18 years or older with histologically proven, unresectable, locally advanced or metastatic, HER2-positive, PD-L1-unselected gastro-oesophageal adenocarcinoma, with an Eastern Cooperative Oncology Group performance status of 0 or 1, who had progressed after at least one previous line of therapy with trastuzumab plus chemotherapy in the locally advanced unresectable or metastatic setting. In the dose-escalation phase, nine patients were treated: three received margetuximab 10 mg/kg intravenously plus pembrolizumab 200 mg intravenously every 3 weeks and six received the recommended phase 2 dose of margetuximab 15 mg/kg plus pembrolizumab 200 mg intravenously every 3 weeks. An additional 86 patients were enrolled in the phase 2 cohort expansion and received the recommended phase 2 dose. The primary endpoints were safety and tolerability, assessed in the safety population (patients who received at least one dose of either margetuximab or pembrolizumab) and the objective response rate as assessed by the investigator according to both Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1, in the response-evaluable population (patients with measurable disease at baseline and who received the recommended phase 2 dose of margetuximab and pembrolizumab). This trial is registered with ClinicalTrials.gov , NCT02689284 . Recruitment for the trial has completed and follow-up is ongoing. Findings Between Feb 11, 2016, and Oct 2, 2018, 95 patients were enrolled. Median follow-up was 19·9 months (IQR 10·7–23·1). The combination therapy showed acceptable safety and tolerability; there were no dose-limiting toxicities in the dose-escalation phase. The most common grade 3–4 treatment-related adverse events were anaemia (four [4%]) and infusion-related reactions (three [3%]). Serious treatment-related adverse events were reported in nine (9%) patients. No treatment-related deaths were reported. Objective responses were observed in 17 (18·48%; 95% CI 11·15–27·93) of 92 evaluable patients. Interpretation These findings serve as proof of concept of synergistic antitumour activity with the combination of an Fc-optimised anti-HER2 agent (margetuximab) along with anti-PD-1 checkpoint blockade (pembrolizumab). Funding MacroGenics.
112 citations
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TL;DR: The NPV scores, measured with the 29-item Likert scale developed by Yeun et al. (2005), were significantly higher in students who entered nursing schools following their aptitude or desire for professional job than in those who entered the schools just because their entrance exam scores were sufficient.
112 citations
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TL;DR: The isolate CNU114001 showed broad spectrum activity against 12 phytopathogenic fungi by dual culture method, and crude antifungal substance showed antagonistic activity against cucumber scleotiorum rot in laboratory, and showed antagonism activity against tomato gray mold, cucumber, and pumpkin powdery mildew in greenhouse condition.
Abstract: A total of 62 bacterial isolates were obtained from Gomsohang mud flat, Mohang mud flat, and Jeju Island, Republic of Korea Among them, the isolate CNU114001 showed significant antagonistic activity against pathogenic fungi by dual culture method The isolate CNU114001 was identified as Bacillus amyloliquefaciens by morphological observation and molecular data analysis, including 16SrDNA and gyraseA (gyrA) gene sequences Antifungal substances of the isolate were extracted and purified by silica gel column chromatography, thin layer chromatography, and high performance liquid chromatography The heat and UV ray stable compound was identified as iturin, a lipopeptide (LP) The isolate CNU114001 showed broad spectrum activity against 12 phytopathogenic fungi by dual culture method The semi purified compound significantly inhibits the mycelial growth of pathogenic fungi (Alternaria panax, Botrytis cinera, Colletotrichum orbiculare, Penicillium digitatum, Pyricularia grisea and Sclerotinia sclerotiorum) at 200 ppm concentration Spore germ tube elongation of Botrytis cinerea was inhibited by culture filtrate of the isolate Crude antifungal substance showed antagonistic activity against cucumber scleotiorum rot in laboratory, and showed antagonistic activity against tomato gray mold, cucumber, and pumpkin powdery mildew in greenhouse condition
112 citations
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TL;DR: H2O2-responsive antioxidant nanoparticles formulated from copolyoxalate containing vanillyl alcohol (VA) (PVAX) are reported as a novel I/R-targeted nanotherapeutic agent that exerted highly potent anti-inflammatory and anti-apoptotic activities that reduced cellular damages in mice.
Abstract: The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the overproduction of reactive oxygen species (ROS). Hydrogen peroxide (H2O2), the most abundant form of ROS produced during I/R, causes inflammation, apoptosis and subsequent tissue damages. Here, we report H2O2-responsive antioxidant nanoparticles formulated from copolyoxalate containing vanillyl alcohol (VA) (PVAX) as a novel I/R-targeted nanotherapeutic agent. PVAX was designed to incorporate VA and H2O2-responsive peroxalate ester linkages covalently in its backbone. PVAX nanoparticles therefore degrade and release VA, which is able to reduce the generation of ROS, and exert anti-inflammatory and anti-apoptotic activity. In hind-limb I/R and liver I/R models in mice, PVAX nanoparticles specifically reacted with overproduced H2O2 and exerted highly potent anti-inflammatory and anti-apoptotic activities that reduced cellular damages. Therefore, PVAX nanoparticles have tremendous potential as nanotherapeutic agents for I/R injury and H2O2-associated diseases.
112 citations
Authors
Showing all 14943 results
Name | H-index | Papers | Citations |
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Hyun-Chul Kim | 176 | 4076 | 183227 |
Andrew Ivanov | 142 | 1812 | 97390 |
Dong-Chul Son | 138 | 1370 | 98686 |
C. Haber | 135 | 1507 | 98014 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Alessandro Cerri | 129 | 1244 | 103225 |
Paul M. Vanhoutte | 127 | 868 | 62177 |
Jason Nielsen | 125 | 893 | 72688 |
Chi Lin | 125 | 1313 | 102710 |
Paul Lujan | 123 | 1255 | 76799 |
Young Hee Lee | 122 | 1168 | 61107 |
Min Suk Kim | 119 | 975 | 66214 |
Alexandre Sakharov | 119 | 582 | 56771 |
Yang-Kook Sun | 117 | 781 | 58912 |
Rui L. Reis | 115 | 1608 | 63223 |