Chonbuk National University

About: Chonbuk National University is a education organization based out in Jeonju, South Korea. It is known for research contribution in the topics: Apoptosis & Nanofiber. The organization has 14820 authors who have published 28884 publications receiving 554131 citations.

Memristor Emulator for Memristor Circuit Applications

Abstract: A memristor emulator which imitates the behavior of a TiO2 memristor is presented. Our emulator is built from off-the-shelf solid state components. To develop real world memristor circuit applications, the emulator can be used for breadboard experiments in real time. Two or more memristor emulators can be connected in serial, in parallel, or in hybrid (serial and parallel combined) with identical or opposite polarities. With a simple change of connection, each memristor emulator can be switched between a decremental configuration or an incremental configuration. The hardware and spice simulation of the proposed emulator showed promising results that provides an alternative solution of hp TiO2 memristor model in real circuit.

Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death

Abstract: Cancer cells, compared with normal cells, are under oxidative stress associated with the increased generation of reactive oxygen species (ROS) including H2O2 and are also susceptible to further ROS insults. Cancer cells adapt to oxidative stress by upregulating antioxidant systems such as glutathione to counteract the damaging effects of ROS. Therefore, the elevation of oxidative stress preferentially in cancer cells by depleting glutathione or generating ROS is a logical therapeutic strategy for the development of anticancer drugs. Here we report a dual stimuli-responsive hybrid anticancer drug QCA, which can be activated by H2O2 and acidic pH to release glutathione-scavenging quinone methide and ROS-generating cinnamaldehyde, respectively, in cancer cells. Quinone methide and cinnamaldehyde act in a synergistic manner to amplify oxidative stress, leading to preferential killing of cancer cells in vitro and in vivo. We therefore anticipate that QCA has promising potential as an anticancer therapeutic agent.