Chonbuk National University

About: Chonbuk National University is a education organization based out in Jeonju, South Korea. It is known for research contribution in the topics: Apoptosis & Graphene. The organization has 14820 authors who have published 28884 publications receiving 554131 citations.

SERS imaging of HER2-overexpressed MCF7 cells using antibody-conjugated gold nanorods

Abstract: Antibody-conjugated gold nanorods (GNRs) have been used for the targeting and imaging of specific cancer markers expressed on the surface membrane of cancer cells. GNRs with various aspect ratios were fabricated, and their surface-enhanced Raman scattering enhancement effects were evaluated. To attach the GNRs selectively onto the targets in cancer cells, specific antibodies were immobilized on the surface of GNRs using the layer-by-layer deposition method. First, Raman reporter molecules, mercaptopyridine, were attached to the surface of GNRs, and their surface charge was modified using poly(sodium 4-styrene-sulfonate) to make the surface charge negative. Then, anti-rabbit IgGs were immobilized onto the surface of the GNRs by electrostatic interactions. HER2 markers, expressed on the cell surface, were treated with anti-HER2 primary antibodies. Finally, the functionalized nanoprobes, conjugated with secondary antibodies, were attached to the markers on cancer cells by antibody–antibody interactions. In the present study, MCF7 cells overexpressing breast cancer marker HER2 were used as the optical imaging targets. Our experimental results demonstrate the potential feasibility of antibody-conjugated GNRs for the highly sensitive targeting and imaging of biomarkers expressed on the surface membrane of cancer cells.

Electrical transport properties of individual gallium nitride nanowires synthesized by chemical-vapor-deposition

Abstract: We have synthesized high-quality gallium nitride (GaN) nanowires by a chemical-vapor-deposition method and studied the electrical transport properties. The electrical measurements on individual GaN nanowires show a pronounced n-type field effect due to nitrogen vacancies in the whole measured temperature ranges. The n-type gate response and the temperature dependence of the current–voltage characteristics could be understood by the band bending at the interface of the metal electrode and GaN wire. The estimated electron mobility from the gate modulation characteristics is about 2.15 cm2/V s at room temperature, suggesting the diffusive nature of electron transport in the nanowires.

Processable high internal phase Pickering emulsions using depletion attraction

Abstract: The fabrication of emulsion droplets stabilized by solid particles adsorbed on the interface is restricted to delicate interfacial conditions. Here, Kim et al. show a general approach to prepare them using the depletion interaction, modified by soluble polymers, between particles and emulsions.