Christ University

About: Christ University is a education organization based out in Bengaluru, India. It is known for research contribution in the topics: Computer science & Convection. The organization has 2267 authors who have published 2715 publications receiving 14575 citations. The organization is also known as: Christ College & Christ University.

Subtractive Genomics Approach to Identify Putative Drug Targets and Identification of Drug-like Molecules for Beta Subunit of DNA Polymerase III in Streptococcus Species

Abstract: The prolonged use of the antibiotics over the years has transformed many organisms resistant to multiple drugs. This has made the field of drug discovery of vital importance in curing various infections and diseases. The drugs act by binding to a specific target protein of prime importance for the cell’s survival. Streptococcus agalactiae, Streptococcus pneumoniae, and Streptococcus pyogenes are the few gram positive organisms that have developed resistance to drugs. It causes pneumonia, meningitis, pharyngitis, otitis media, sinusitis, bacteremia, pericarditis, and arthritis infections. The present study was carried out to identify potential drug targets and inhibitors for beta subunit of DNA polymerase III in these three Streptococcus species that might facilitate the discovery of novel drugs in near future. Various steps were adopted to find out novel drug targets. And finally 3D structure of DNA polymerase III subunit beta was modeled. The ligand library was generated from various databases to find the most suitable ligands. All the ligands were docked using Molegro Virtual Docker and the lead molecules were investigated for ADME and toxicity.

Dust reverberation mapping of Z229–15

Abstract: We report results of the dust reverberation mapping (DRM) on the Seyfert 1 galaxy Z229-15 at z = 0.0273. Quasi-simultaneous photometric observations for a total of 48 epochs were acquired during the period 2017 July to 2018 December in B, V, J, H and Ks bands. The calculated spectral index ({\alpha}) between B and V bands for each epoch was used to correct for the accretion disk (AD) component present in the infrared light curves. The observed {\alpha} ranges between -0.99 and 1.03. Using cross correlation function analysis we found significant time delays between the optical V and the AD corrected J, H and Ks light curves. The lags in the rest frame of the source are 12.52 (+10.00/-9.55) days (between V and J), 15.63 (+5.05/-5.11) days (between V and H) and 20.36 (+5.82/-5.68) days (between V and Ks). Given the large error bars, these lags are consistent with each other. However, considering the lag between V and Ks bands to represent the inner edge of the dust torus, the torus in Z229-15 lies at a distance of 0.017 pc from the central ionizing continuum. This is smaller than that expected from the radius luminosity (R-L) relationship known from DRM. Using a constant {\alpha} = 0.1 to account for the AD component, as is normally done in DRM, the deduced radius (0.025 pc) lies close to the expected R-L relation. However, usage of constant {\alpha} in DRM is disfavoured as the {\alpha} of the ionizing continuum changes with the flux of the source.

Rectangular microstrip antenna for WLAN application

Abstract: This paper deals with the design of rectangular microstrip patch antenna for Wireless applications. In this paper a modified slotted microstrip antenna design for 2.5GHz operation is proposed. This provides improved performance in terms of lower return loss and higher gain. This is possible by inclusion of slots appropriately on the patch shape. The substrate material used in this design is Duroid5880 with permittivity 2.2 and size 47.43mm × 39.65mm × 1.6mm. ANSOFT HFSS EM simulator has been used for design and simulation of the microstrip antenna. The various antenna parameters such as frequency, VSWR, gain and directivity are analyzed to characterize the proposed antenna.

Islanding detection technique of distribution generation system

Abstract: Islanding is a condition in which the micro grid is disconnected from the main grid which consists of loads and distribution generation. Islanding is required whenever there is a fault and whenever the maintenance is required. Under normal condition or stable condition, the system works under constant current control mode. After islanding the system switched to voltage controlled mode. There are different methods that can be used to detect islanding situation such as active and passive methods. In this paper DQ-PLL detection technique used for detecting islanding condition is carried out. This paper also explains in detail the advantages of DQ-PLL method for islanding detection The implementation is validated by using MATLAB/SIMULINK software.

Characterization of Diesel Soot from the Combustion in Engine by X-ray and Spectroscopic techniques

Abstract: 1 April 2012 Carbon nanomaterials formed during the combustion of Diesel inside engine is characterized by X-ray diffraction (XRD) and spectroscopic techniques The soot are collected from the Engine and washed with Acetone Carbon Nanomaterials produced from diesel soot show the morphology of carbon nanospheres mixed with carbon nanotubes X-ray diffraction investigation shows the presence of carbon nanotubes in association with amorphous nanomaterial EDS analysis of Diesel soot indicates that the soot particles to be composed of primarily carbon and oxygen along with hydrogen NMR spectrum of the soot reveals significant aliphatic component with predominance of methyl and methylene groups on β and γ positions to aromatic rings There is significant fraction of hydrogen on the γ position at 0864 ppm, which suggests the existence of large aliphatic chains or saturated rings joined to aromatic rings The IR spectrum shows characteristic signals in the region 1700-1000 cm