CHU Ambroise Paré

About: CHU Ambroise Paré is a healthcare organization based out in Mons, Belgium. It is known for research contribution in the topics: Population & Interventional radiology. The organization has 129 authors who have published 112 publications receiving 5880 citations. The organization is also known as: Hopital Ambroise Pare.

Serum concentration and vascular expression of adiponectin are differentially associated with the diabetic calcifying peripheral arteriopathy.

Abstract: Background: Medial calcification in diabetes contributes to the arterial occlusive process occurring below the knee level. Adiponectin is an adipokine with atheroprotective properties and possible protective role against arterial calcification. The aim of the study was to investigate, in type 2 diabetes, the link between vascular expression and serum concentration of adiponectin and (1) peripheral arterial calcification and (2) lower limb occlusive arterial disease. Methods: Scoring of peripheral vascular calcification and peripheral arterial occlusive disease, using CT-scan and color-duplex ultrasonography respectively, were conducted and explored in relation to serum adiponectin level in a cross sectional study of 197 patients with type 2 diabetes. Vascular adiponectin expression in the arterial wall of diabetic patients with and without medial calcification was evaluated by immunohistochemistry. Results: Peripheral arterial calcification score was higher in patients with the highest adiponectin concentration. In a multivariate logistic regression analysis, an increase of 1 µg/mL of adiponectin was associated with a 22% increase of arterial calcification (adjusted OR = 1.22; 95% CI 1.03–1.44; p = 0.02). Arterial occlusive score was also higher in patients with adiponectin concentration > median (2.8 ± 4.8 vs 4.2 ± 5.7, p = 0.034). Immunohistochemical analyses showed a strong and specific staining of adiponectin in smooth muscle cells in calcified arteries, with a more pronounced expression of adiponectin in early stages of medial calcification. Conclusions: Peripheral arterial calcification is positively associated with circulating adiponectin levels in patients with type 2 diabetes, but vascular adiponectin expression is already observed at early stages of calcification. Adiponectin secretion could be a compensatory mechanism against the calcification process.

Classification algorithm for the International Classification of Diseases-11 chronic pain classification: development and results from a preliminary pilot evaluation.

Abstract: The International Classification of Diseases-11 (ICD-11) chronic pain classification includes about 100 chronic pain diagnoses on different diagnostic levels. Each of these diagnoses requires specific operationalized diagnostic criteria to be present. The classification comprises more than 200 diagnostic criteria. The aim of the Classification Algorithm for Chronic Pain in ICD-11 (CAL-CP) is to facilitate the use of the classification by guiding users through these diagnostic criteria. The diagnostic criteria were ordered hierarchically and visualized in accordance with the standards defined by the Society for Medical Decision Making Committee on Standardization of Clinical Algorithms. The resulting linear decision tree underwent several rounds of iterative checks and feedback by its developers, as well as other pain experts. A preliminary pilot evaluation was conducted in the context of an ecological implementation field study of the classification itself. The resulting algorithm consists of a linear decision tree, an introduction form, and an appendix. The initial decision trunk can be used as a standalone algorithm in primary care. Each diagnostic criterion is represented in a decision box. The user needs to decide for each criterion whether it is present or not, and then follow the respective yes or no arrows to arrive at the corresponding ICD-11 diagnosis. The results of the pilot evaluation showed good clinical utility of the algorithm. The CAL-CP can contribute to reliable diagnoses by structuring a way through the classification and by increasing adherence to the criteria. Future studies need to evaluate its utility further and analyze its impact on the accuracy of the assigned diagnoses.

Irinotecan as palliative chemotherapy for metastatic colorectal cancer: evolving tactics following initial treatment.

Abstract: Background Patients with metastatic colorectal cancer (mCRC) who progress despite treatment with fluoropyrimidine and irinotecan or oxaliplatin have diminished survival, but they may derive clinically meaningful benefit from second-line or later chemotherapy.

« Regards croisés 2009 »: enquête menée auprès de patients atteints de cancer et de professionnels de santé sur la perception de la fatigue et de l'anémie chimio-induite

Abstract: L’enquete ≪ Regards croises ≫ a ete realisee en 2009, aupres de patients atteints de cancer et de professionnels de sante, pour evaluer et comparer leur perception de la prise en charge de la fatigue et de l’anemie chimioinduite. Les 300 patients inclus presentaient une tumeur solide (cancer du sein, du poumon ou colorectal) ou une hemopathie maligne non myeloide. Ils etaient traites par chimiotherapie et presentaient ou avaient presente une anemie (Hb < 11 g/dl). Tous les patients ont complete un auto-questionnaire remis par leur medecin. Les 359 professionnels de sante inclus etaient en charge de patients cancereux (250 medecins: oncologues, hematologues, gastroenterologues, pneumologues; 109 infirmieres) et ont repondu a un entretien telephonique. La fatigue est l’effet indesirable de la chimiotherapie le plus souvent cite par les patients (77 %). Comme decrit dans les enquetes precedentes, la fatigue reste en tete des complications qui affectent le plus la vie quotidienne des patients (37 %). La perception des professionnels de sante sur la fatigue et sa necessaire prise en charge est proche de celle des patients, ce qui montre une evolution des mentalites. Les professionnels de sante ont aujourd’hui conscience que la fatigue et les causes de cette fatigue doivent etre prises en compte dans le suivi des patients traites par chimiotherapie. L’integralite des resultats de l’enquete sera detaillee dans les publications suivantes.

Consensus en endoscopie digestive: hémostase endoscopique des hémorragies digestives hautes

Abstract: L’endoscopie en urgence permet le diagnostic etiologique et le traitement hemostatique des hemorragies d’origine haute. Par endoscopie en urgence, on entend generalement une endoscopie realisee dans les 24 premieres heures (cf. Consensus SFED : Endoscopie en urgence). Cependant, en cas d’hemorragie presumee active, l’endoscopie doit etre realisee plus precocement des que l’etat hemodynamique le permet. Elle sera idealement realisee par un operateur experimente, sous anesthesie generale, en salle d’endoscopie, en utilisant un videoendoscope et avec l’aide d’une infirmiere, ou personnel paramedical, formee aux gestes d’hemostase endoscopique. La pose d’une sonde nasogastrique a l’interet discutable et au caractere invasif n’est plus recommandee de facon systematique. Il faut preferer la perfusion par voie intraveineuse d’erythromycine (3 mg/kg ou 250 mg) dans les 30 minutes qui precedent l’endoscopie qui augmente la probabilite que l’estomac soit vide de sang. En cas d’hypertension portale connue ou probable, un traitement vasoactif par voie veineuse doit etre debute le plus tot possible. La somatostatine (Somatostatine®) et ses analogues (octreotide) sont aussi efficaces et mieux toleres que la vaso pressine ou terlipresine (Glypressine®). En cas de persistance de l’hemorragie, malgre le traitement vasoactif, l’endoscopie sera realisee des que possible. Si le traitement vasoactif est actif et le patient stabilise, l’endoscopie sera realisee dans les meilleures conditions pour un geste therapeutique. En cas d’hemorragie ulcereuse, la classification de Forrest est bien correlee aux risques de recidive hemorragique. En l’absence de traitement endoscopique, les risques de recidive hemorragique sont, en cas d’ulceres Forrest Ia (hemorragie en jet), Ib (suintement diffus), IIa (vaisseau visible non hemorragique), IIb (caillot adherent), IIc (taches pigmentees) et III (cratere blanc jaunâtre a fond propre), de respectivement 90, 20, 50, 20, 7 et 3 %. Sauf traitement par les antivitamines K et a fortiori en cas de surdosage, des biopsies gastriques peuvent etre pratiquees lors de l’endoscopie initiale, surtout en l’absence de prise d’anti-inflammatoires non steroidiens, afin de rechercher une infection a Helicobacter pylori, meme si le traitement ne sera le plus souvent instaure qu’une fois la phase aigue passee. En cas d’hemorragie G. Lesur () Hopital Ambroise-Pare, 9, avenue Charles-de-Gaulle, F-92104 Boulogne cedex, France gilles.lesur@apr.aphp.fr e-mail :