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Showing papers by "Chung-Ang University published in 2006"


Journal ArticleDOI
TL;DR: The levels of depression and suicide ideation were highest in the Internet-addicts group, and future studies should investigate the direct relationship between psychological health problems and Internet dependency.

725 citations


Journal ArticleDOI
TL;DR: A new cyclam derivative having two different fluorophores of pyrene and NBD subunits exhibited a selective Hg2+/Cu2+-induced OFF-ON-OFF type of signaling pattern that can be utilized for the construction of functional supramolecular switching systems.

270 citations


Journal ArticleDOI
TL;DR: The selective and sensitive signaling behaviors were found to originate from the Hg2+ ion induced transformation of the very weak fluorescent thioamide derivative into a highly fluorescent amide analogue.

263 citations


Journal ArticleDOI
Juan Antonio Aguilar-Saavedra1, Ahmed Ali, Benjamin C. Allanach2, Richard L. Arnowitt3, Howard Baer4, Jonathan Bagger5, Csaba Balázs6, Vernon Barger7, Michael Barnett8, A. Bartl9, Marco Battaglia8, Philip Bechtle10, Geneviève Bélanger, Alexander Belyaev11, Edmond L. Berger6, G.A. Blair12, Edouard Boos13, Marcela Carena14, S.Y. Choi15, Frank F. Deppisch, A. De Roeck16, Klaus Desch17, Marco Aurelio Diaz18, Abdelhak Djouadi19, Bhaskar Dutta3, S. Dutta10, S. Dutta20, Helmut Eberl21, John Ellis16, Jens Erler22, H. Fraas23, Ayres Freitas24, T. Fritzsche25, Rohini M. Godbole26, G. Gounaris27, Jaume Guasch28, John F. Gunion29, Naoyuki Haba30, Howard E. Haber31, K. Hagiwara, Liyuan Han32, Tao Han7, Hong-Jian He33, Sven Heinemeyer16, S. Hesselbach34, Keisho Hidaka35, I. Hinchliffe8, Martin Hirsch36, K. Hohenwarter-Sodek9, Wolfgang Hollik25, W. S. Hou37, Tobias Hurth16, Tobias Hurth10, I. Jack38, Yi Jiang32, D.R.T. Jones38, J. Kalinowski39, T. Kamon3, Gordon L. Kane40, Sin Kyu Kang41, Thomas Kernreiter9, Wolfgang Kilian, Choong Sun Kim42, Stephen F. King43, O. Kittel44, Michael Klasen, J. L. Kneur45, K. Kovarik21, Michael Kramer46, Sabine Kraml16, Remi Lafaye47, Paul Langacker48, Heather E. Logan49, W. G. Ma32, W. Majerotto21, H. U. Martyn46, Konstantin Matchev50, David J. Miller51, Myriam Mondragón22, Gudrid Moortgat-Pick16, Stefano Moretti43, Takehiko Mori52, Gilbert Moultaka45, Steve Muanza53, M. M. Mühlleitner, Biswarup Mukhopadhyaya54, U. Nauenberg55, Mihoko M. Nojiri56, D. Nomura11, H. Nowak, N. Okada, Keith A. Olive57, W. Oller21, Michael E. Peskin10, Tilman Plehn25, Giacomo Polesello, Werner Porod24, Werner Porod36, Fernando Quevedo2, David L. Rainwater58, Jürgen Reuter, Peter J. Richardson59, Krzysztof Rolbiecki39, Probir Roy60, Reinhold Rückl23, Heidi Rzehak61, P. Schleper62, Kim Siyeon63, Peter Skands14, P. Slavich, Dominik Stöckinger59, Paraskevas Sphicas16, Michael Spira61, Tim M. P. Tait6, Daniel Tovey64, José W. F. Valle36, Carlos E. M. Wagner6, Carlos E. M. Wagner65, Ch. Weber21, Georg Weiglein59, Peter Wienemann17, Z.-Z. Xing, Y. Yamada66, Jin Min Yang, D. Zerwas19, P.M. Zerwas, Ren-You Zhang32, X. Zhang, S.-H. Zhu67 
University of Lisbon1, University of Cambridge2, Texas A&M University3, Florida State University4, Johns Hopkins University5, Argonne National Laboratory6, University of Wisconsin-Madison7, Lawrence Berkeley National Laboratory8, University of Vienna9, Stanford University10, Michigan State University11, Royal Holloway, University of London12, Moscow State University13, Fermilab14, Chonbuk National University15, CERN16, University of Freiburg17, Pontifical Catholic University of Chile18, University of Paris19, University of Delhi20, Austrian Academy of Sciences21, National Autonomous University of Mexico22, University of Würzburg23, University of Zurich24, Max Planck Society25, Indian Institute of Science26, Aristotle University of Thessaloniki27, University of Barcelona28, University of California, Davis29, University of Tokushima30, University of California, Santa Cruz31, University of Science and Technology of China32, Tsinghua University33, Uppsala University34, Tokyo Gakugei University35, Spanish National Research Council36, National Taiwan University37, University of Liverpool38, University of Warsaw39, University of Michigan40, Seoul National University41, Yonsei University42, University of Southampton43, University of Bonn44, University of Montpellier45, RWTH Aachen University46, Laboratoire d'Annecy-le-Vieux de physique des particules47, University of Pennsylvania48, Carleton University49, University of Florida50, University of Glasgow51, University of Tokyo52, University of Lyon53, Harish-Chandra Research Institute54, University of Colorado Boulder55, Kyoto University56, University of Minnesota57, University of Rochester58, Durham University59, Tata Institute of Fundamental Research60, Paul Scherrer Institute61, University of Hamburg62, Chung-Ang University63, University of Sheffield64, University of Chicago65, Tohoku University66, Peking University67
TL;DR: In this article, a supersymmetry Parameter Analysis SPA (SPA) scheme is proposed based on a consistent set of conventions and input parameters, which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e(+)e(-) linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles.
Abstract: High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A repository for computer programs is provided which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e(+)e(-) linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles. In addition, programs for calculating high-precision low energy observables, the density of cold dark matter (CDM) in the universe as well as the cross sections for CDM search experiments are included. The SPA scheme still requires extended efforts on both the theoretical and experimental side before data can be evaluated in the future at the level of the desired precision. We take here an initial step of testing the SPA scheme by applying the techniques involved to a specific supersymmetry reference point.

234 citations


Book ChapterDOI
01 Jan 2006
TL;DR: Particle Swarm Optimization (PSO) incorporates swarming behaviors observed in flocks of birds, schools of fish, or swarms of bees, and even human social behavior, and compares favorably with many global optimization algorithms.
Abstract: Swarm Intelligence (SI) is an innovative distributed intelligent paradigm for solving optimization problems that originally took its inspiration from the biological examples by swarming, flocking and herding phenomena in vertebrates. Particle Swarm Optimization (PSO) incorporates swarming behaviors observed in flocks of birds, schools of fish, or swarms of bees, and even human social behavior, from which the idea is emerged [14, 7, 22]. PSO is a population-based optimization tool, which could be implemented and applied easily to solve various function optimization problems, or the problems that can be transformed to function optimization problems. As an algorithm, the main strength of PSO is its fast convergence, which compares favorably with many global optimization algorithms like Genetic Algorithms (GA) [13], Simulated Annealing (SA) [20, 27] and other global optimization algorithms. For applying PSO successfully, one of the key issues is finding how to map the problem solution into the PSO particle, which directly affects its feasibility and performance. Ant Colony Optimization (ACO) deals with artificial systems that is inspired from the foraging behavior of real ants, which are used to solve discrete

230 citations


Journal ArticleDOI
TL;DR: In this paper, numerical simulation was carried out to analyze the effect of the aspect ratio on smoke movement in tunnel fires using FDS 3.0, which confirmed the possibility of application of FDS code to tunnel fires.

165 citations


Journal ArticleDOI
TL;DR: This article examined the significance of international knowledge spillovers through inward and outward foreign direct investment (FDI), intermediate goods imports, and a disembodied direct channel using panel data from 16 OECD countries for the period 1981-2000.

162 citations


Journal ArticleDOI
01 Apr 2006-Eye
TL;DR: Systemically transplanted MSCs can engraft to injured cornea to promote wound healing, by differentiation, proliferation, and synergizing with haemotopoietic stem cells.
Abstract: To investigate whether systemically transplanted mesenchymal stem cells (MSCs) can home and engraft in tissue to promote cornea wound healing after alkali burn, as a new source for treatment. Corneal alkali burn was created in four group rabbits: Group I, normal bone marrow function, without MSCs transplantation; Group II, normal bone marrow function, with MSCs transplantation; Group III, bone marrow suppressed by cyclophosphamide, without MSCs; Group IV, bone marrow suppressed by cyclophosphamide, with MSCs. Clinical outcome was evaluated by cornea re-epithelization, cornea opacity, and neovascularization. Cell engraftment into bone marrow, circulation, and cornea was monitored. Immunohistochemistry, using proliferating cell nuclear antigen (PCNA), P63, vimentin, and α-smooth muscle actin (α-SMA) was carried out to assess the cell proliferative and differentiative ability. At the time of 1-month follow-up, Group II rabbits showed the best clinical results with a clearer healed cornea compared with other groups. Well-formed neovascularization appeared on day 14 after alkali burn in Group II, that coincided with the maximum engraftment of MSCs. PCNA, P63, vimentin were more strongly expressed in Group II at multiple time points. DiI-labelled MSCs were differentiated into myofibroblast by the expression of α-SMA. Delayed and insufficient cell engraftment, with malformed neovascularization and retarded corneal wound healing was found in Groups III and IV. Systemically transplanted MSCs can engraft to injured cornea to promote wound healing, by differentiation, proliferation, and synergizing with haemotopoietic stem cells.

149 citations


Journal ArticleDOI
TL;DR: Moreira et al. as discussed by the authors studied the prevalence of sexual problems and associated help-seeking patterns among mature adults in Korea and compared the results with those obtained in other Southeast Asian and East Asian countries.

148 citations


Journal ArticleDOI
TL;DR: The results indicated that key regulators in BV-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of the ERK and Akt signal pathway.

126 citations


Journal ArticleDOI
TL;DR: The freeze drying process of nanocrystal dispersions was examined at varying freezing rates and a critical freezing rate, below which the dried nanocrystals cannot be re-dispersed, was identified based on the plot of the particle size of reconstituted nanocry crystals versus freezing rate.

Journal ArticleDOI
TL;DR: In this paper, the effects of thermal boundary conditions and flow fields on flame propagation were numerically investigated using a finite volume method using an adaptive grid method, and strong similarity in the flame structure was found regardless of the boundary velocity profiles due to selfinduced velocity deformation.

Journal ArticleDOI
TL;DR: The discovery of RraB is reported, which interacts with a different site on RNase E and interferes with cleavage of a different set of transcripts and is argued that such degradosome remodelling is a mechanism for the differential regulation of RNA cleavages in E.’coli.
Abstract: In Escherichia coli the initial step in the processing or decay of many messenger and structural RNAs is mediated by the endonuclease RNase E, which forms the core of a large RNA-catalysis machine termed the degradosome. Previous experiments have identified a protein that globally modulates RNA abundance by binding to RNase E and regulating its endonucleolytic activity. Here we report the discovery of RraB, which interacts with a different site on RNase E and interferes with cleavage of a different set of transcripts. We show that expression of RraA or RraB in vivo is accompanied by dramatic, distinct, and inhibitor-specific changes in degradosome composition--and that these are in turn associated with alterations in RNA decay and global transcript abundance profiles that are dissimilar to the profile observed during simple RNase E deficiency. Our results reveal the existence of endonuclease binding proteins that modulate the remodelling of degradosome composition in bacteria and argue that such degradosome remodelling is a mechanism for the differential regulation of RNA cleavages in E. coli.

Journal ArticleDOI
TL;DR: An awareness of the potential pitfalls of integrated PET-CT enhances the diagnostic efficacy of this modality by allowing differentiation of metastatic adrenal lesions from other abnormalities.
Abstract: Integrated fluorine-18 fluorodeoxyglucose positron emission tomography (PET)-computed tomography (CT) for adrenal gland imaging in cancer patients allows early detection and accurate localization of adrenal lesions and differentiation of metastatic nodules from benign lesions, thereby facilitating treatment planning. However, false-positive findings are encountered at integrated PET-CT in approximately 5% of adrenal lesions identified as positive at PET, including adrenal adenomas, adrenal endothelial cysts, and inflammatory and infectious lesions. Moreover, false-negative findings may be seen in adrenal metastatic lesions with hemorrhage or necrosis, small-sized (<10-mm) metastatic nodules, and metastases from pulmonary bronchioloalveolar carcinoma or carcinoid tumors. An awareness of the potential pitfalls of integrated PET-CT enhances the diagnostic efficacy of this modality by allowing differentiation of metastatic adrenal lesions from other abnormalities.

Journal ArticleDOI
TL;DR: It is suggested that orchiectomy accelerates the post-ischemic activation of MnSOD and reduces reactive oxygen species and lipid peroxidation, resulting in reduced kidney susceptibility to I/R injury.

Journal ArticleDOI
TL;DR: The proposed approach was applied for two real-world problems involving designing intrusion detection system (IDS) and for breast cancer classification and empirical results indicate that the proposed method is efficient for both input feature selection and improved classification rate.

Journal ArticleDOI
TL;DR: This paper used a collaborative assessment protocol to compare the self-reported teaching beliefs of a convenience sample of preschool teachers to their documentable practices (i.e., practices that could be observed, recorded, and categorized using a deductive strategy).
Abstract: A team of researchers used a collaborative assessment protocol to compare the self-reported teaching beliefs of a convenience sample of preschool teachers (N = 57) to their documentable practices (i.e., practices that could be observed, recorded, and categorized using a deductive strategy). Data were examined from survey instruments, detailed classroom observations and time-sampling, curriculum materials, and program artifacts. Results indicated that when child-directed choice/play time, emergent literacy and language development activities were emphasized, teachers self-reported beliefs were more strongly aligned with developmentally appropriate practice (DAP) as a philosophy of practice. When consistent routines, organized classrooms, preplanned curriculum, and teacher-directed learning were the dominant behaviors, the teachers were found to report more “traditional” or academic-oriented beliefs.

Journal ArticleDOI
TL;DR: Results indicate that phenolic compounds of GE are anti-inflammatory, which may be related to inhibition of COX activity and to anti-oxidant activity.
Abstract: Previous screening of the pharmacological action ofGastrodia elata (GE) root (Orchidaceae) showed that methanol (MeOH) extracts have significant anti-inflammatory properties. The anti-inflammatory agents of GE, however, remain unclear. In this experiment, MeOH extracts of GE were fractionated with organic solvents for the anti-inflammatory activity-guided separation of GE. Eight phenolic compounds from the ether (EtOEt) and ethyl acetate (EtOAc) fractions were isolated by column chromatography: 4-hydroxybenzaldehyde (I), 4-hydroxybenzyl alcohol (II), benzyl alcohol (III), bis-(4-hydroxyphenyl) methane (IV), 4(4′-hydroxybenzyloxy)benzyl methylether (V), 4-hydroxy-3-methoxybenzyl alcohol (VI), 4-hydroxy-3-methoxybenzaldehyde (VII), and 4-hydroxy-3-methoxybenzoic acid (VIII). To investigate the anti-inflammatory and anti-oxidant activity of these compounds, their effects on carrageenan-induced paw edema, arachidonic acid (AA)-induced ear edema and analgesic activity in acetic acid (HAc)-induced writhing response were carried outin vivo; cyclooxygenase (COX) activity, reactive oxygen species (ROS) generation in rat basophilic leukemia (RBL 2H3) cells and 1,1-diphenyl-2-picryl-hydroazyl (DPPH) scavenging activity were determinedin vitro. These phenolic compounds not only had anti-inflammatory and analgesic propertiesin vivo, but also inhibited COX activity and silica-induced ROS generation in a dose-dependent manner. Among these phenolic compounds, compound VII was the most potent anti-inflammatory and analgesic. Compound VII significantly inhibited silica-induced ROS generation and compound VI significantly increased DPPH radical scavenging activity. Compounds I, II and III significantly inhibited the activity of COX-I and II. These results indicate that phenolic compounds of GE are anti-inflammatory, which may be related to inhibition of COX activity and to anti-oxidant activity. Consideration of the structure-activity relationship of the phenolic derivatives from GE on the anti-inflammatory action revealed that both C-4 hydroxy and C-3 methoxy radicals of benzyl aldehyde play an important role in anti-inflammatory activities.

Book ChapterDOI
09 Oct 2006
TL;DR: A novel approach based on Particle Swarm Optimization (PSO) for scheduling jobs on computational grids by extending the representations of the position and velocity of the particles in the conventional PSO is extended from the real vectors to fuzzy matrices.
Abstract: Grid computing is a computing framework to meet the growing computational demands. This paper introduces a novel approach based on Particle Swarm Optimization (PSO) for scheduling jobs on computational grids. The representations of the position and velocity of the particles in the conventional PSO is extended from the real vectors to fuzzy matrices. The proposed approach is to dynamically generate an optimal schedule so as to complete the tasks within a minimum period of time as well as utilizing the resources in an efficient way. We evaluate the performance of the proposed PSO algorithm with Genetic Algorithm (GA) and Simulated Annealing (SA) approaches.

Journal ArticleDOI
TL;DR: In this paper, the socio-political impact of the so-called IMF reforms that were implemented by the South Korean government in response to the financial crisis of 1997-98 is analyzed.
Abstract: This article provides a partial analysis of the socio-political impact of the so-called IMF reforms that were implemented by the South Korean government in response to the financial crisis of 1997–98. We find that at least in one key area — namely policies related to foreign investment — the IMF reforms fundamentally altered and reshaped Korea's development path. In fact, the policy changes affecting foreign investment produced what amounts to a paradigm shift in Korea's well-known model of developmental state. Alternatively put, these reforms led to the demise of the “Korea, Inc.,” the symbiotic relationship between government and businesses that was at the core of Korea's developmental state. As such, our analysis suggesting a paradigm shift in Korea's developmental state stands in contrast with previous (pre-crisis) arguments that proclaimed the demise of the developmental state.

Journal ArticleDOI
TL;DR: In this article, a single-walled carbon nanotube (CNT) oscillator based on a single CNT bundle was investigated using classical molecular dynamics simulations, and the authors presented the schematics of a CNT oscillator that could be initiated by an electrostatic capacitive force.
Abstract: Carbon nanotube (CNT) oscillators based on a single-walled CNT bundle were investigated using classical molecular dynamics simulations. We present the schematics of a CNT bundle oscillator that could be initiated by an electrostatic capacitive force. While the capacitive force acting on a CNT oscillator extruded it, the force exerted on the CNT oscillator by the excess van der Waals energy sucked it into the bundle. Therefore, the CNT oscillator could be oscillated by both Coulomb and the van der Waals interactions. The operation frequency of a CNT bundle oscillator could be controlled by both the size and the length of the bundle. Our molecular dynamics simulation results showed unique features of the CNT bundle oscillators such as chaotic signature and high damping rate. CNT oscillation in the bundle showed the coupled motion to be dependent on other CNTs rather than a collective motion of the bundle. As the number of CNTs in the bundle oscillator increased, the chaotic signature of the CNT bundle oscillator increased with the increasing of coupled CNTs.

Journal Article
TL;DR: PPChecker as discussed by the authors calculates the amount of data copied from the original document to the query document, based on linguistically-motivated plagiarism patterns, and produces better decision information for document copy detection than existing systems.
Abstract: Nowadays, most of documents are produced in digital format, in which they can be easily accessed and copied. Document copy detection is a very important tool for protecting the author's copyright. We present PPChecker, a document copy detection system based on plagiarism pattern checking. PPChecker calculates the amount of data copied from the original document to the query document, based on linguistically-motivated plagiarism patterns. Experiments performed on CISI document collection show that PPChecker produces better decision information for document copy detection than existing systems.

Journal ArticleDOI
TL;DR: Comprehensive data on the distribution of SVCT proteins in adult rat brain by using immunohistochemical techniques for the first time is developed and could be the basis for further studies on related subjects.
Abstract: Sodium-dependent vitamin C transporters (SVCTs) is known to transport the reduced form of ascorbic acid into the cell, whereas the oxidized form of vitamin C (VC) is moved through a facilitative sugar transporter, such as glucose transporter (GLUT). With regard to the distribution of SVCT1 and -2 within the various organs, they were reported to be expressed in different types of cells. Especially in the central nervous system, only SVCT2 mRNA was expressed mainly in neurons and some types of neuroglial cells. However, data on the expression of SVCT proteins in the brain are scant. Therefore, we tried to develop comprehensive data on the distribution of SVCT proteins in adult rat brain by using immunohistochemical techniques for the first time. In our study, SVCT2 immunoreactivities (IRs) were intensely localized in the neurons of cerebral cortex, hippocampus, and Purkinje cells of cerebellum, and much weaker SVCT2 IRs were found in the other brain regions. Judging from double-immunohistochemical data, most of the cells expressing SVCT2 IRs were likely to be neurons or microglia, even though the cells in choroids plexus or ependymal cells around the ventricles also exhibited SVCT2 IRs. Complete mapping of the distribution of SVCT2 IRs was available by using a semiquantitative method. The subcellular localization of SVCT proteins is necessary for understanding the exact role of the protein, so the current overall mapping of SVCT IRs in the rat brain could be the basis for further studies on related subjects.

Journal ArticleDOI
TL;DR: An autonomous mobile robot with optimal two-layer fuzzy controller with color detection system was introduced and the efficacies of the 2LFC, the SCEA, and the teleoperation system were verified.
Abstract: Research on Internet-based teleoperation has received increased attention in the past few years In this paper, an Internet-based teleoperation system was implemented In order to robustly transmit the surroundings and control information of the robot, packet-type data were used The central problem in Internet-based teleoperation is data transmission latency or data loss For this specific problem, an autonomous mobile robot with optimal two-layer fuzzy controller (2LFC) was introduced When data transmission is failed, the robot automatically moves and protects itself In addition, a color detection system was implemented so that the robot can perceive an object and move to another object The fuzzy controller was optimized by using the schema coevolutionary algorithm (SCEA), which finds an optimal solution Using these technologies, the efficacies of the 2LFC, the SCEA, and the teleoperation system were verified

Book ChapterDOI
11 Sep 2006
TL;DR: Experiments performed on CISI document collection show that PPChecker produces better decision information for document copy detection than existing systems.
Abstract: Nowadays, most of documents are produced in digital format, in which they can be easily accessed and copied. Document copy detection is a very important tool for protecting the author’s copyright. We present PPChecker, a document copy detection system based on plagiarism pattern checking. PPChecker calculates the amount of data copied from the original document to the query document, based on linguistically-motivated plagiarism patterns. Experiments performed on CISI document collection show that PPChecker produces better decision information for document copy detection than existing systems.

Journal ArticleDOI
TL;DR: Bis(pyrene) derivative of diazatetrathia-crown ether has been prepared and its Hg 2+ -selective fluoroionophoric properties were investigated as discussed by the authors.

Patent
15 Dec 2006
TL;DR: In this article, the authors described a method for digital image restoration, including the steps of receiving an external deteriorated image and generating N restoration images by using a preset PSF and an image restoration filter without computing a PSF of the input deteriorated image, dividing the restoration images into window parts of a predetermined window size, computing absolute values of differences among peripheral pixels within the divided window parts, selecting only a high frequency part, and analyzing focus deterioration.
Abstract: Methods and apparatus are disclosed for digital image restoration. The method including the steps of receiving an external deteriorated image, and generating N restoration images by using a preset PSF and an image restoration filter without computing a PSF of the input deteriorated image, dividing the restoration images into window parts of a predetermined window size, computing absolute values of differences among peripheral pixels within the divided window parts, selecting only a high frequency part, and analyzing focus deterioration; determining weights of the N restoration images, selecting window parts having high weights, and integrating the selected window parts into one image and comparing a degree of restoration of the integrated image with a preset degree of restoration, and outputting the integrated image as a resultant image when the degree of restoration of the integrated image is higher than the preset degree of restoration.

Journal ArticleDOI
TL;DR: Plasmidmediated AmpC gene allele-positive isolates were present both in large city and in small province hospitals, as well as in isolates from outpatients, suggesting unhindered future spread of these resistances.
Abstract: Cefoxitin-resistant Escherichia coli and Klebsiella pneumoniae are relatively prevalent in Korea, suggesting dissemination of plasmid-mediated AmpC β-lactamases. In this study, 238 isolates of cefoxitin-resistant E. coli and K. pneumoniae (not including subspecies ozaenae and rhinoscleromatis) were collected in 2003 from 16 Korean hospitals. The prevalence of plasmid-mediated AmpC β-lactamases was determined by PCR. The AmpC gene alleles detected in E. coli and K. pneumoniae were bla DHA-1, 10 (8.6%) and 93 (76.2%); bla CMY-1-like, 14 (12.1%) and 2 (1.6%); and bla CMY-2-like, 38 (32.7%) and 1 (0.8%) isolates, respectively. The genes identified were bla DHA-1, bla CMY10-like, and bla CMY-2-like, and a new variant, bla CMY-18. Plasmidmediated AmpC gene allele-positive isolates were present both in large city and in small province hospitals, as well as in isolates from outpatients. The proportions of plasmid-mediated AmpC gene-positive isolates were similar in both expanded spectrum β-lactamase (ESBL)-produc...

Journal ArticleDOI
TL;DR: The present study has clearly shown the localization of TR PCs in rat hippocampus and may provide useful data for the future investigations on the structural and functional properties of TRPCs.

Journal ArticleDOI
TL;DR: The theory that COMTL allele was related with increased tonic dopamine activity and cognitive ‘stability’, which may induce cognitive inflexibility in schizophrenia, is supported.
Abstract: We assessed catechol-O-methyltransferase (COMT) polymorphism in 132 first-onset schizophrenic patients and 80 healthy controls. The relationship between COMT polymorphism and cognitive function, aggression and psychiatric symptoms was tested in the schizophrenic group. COMT L carrier had higher digit span score and lower similarity score than COMT H homozygote. COMT L carrier had higher attention and delusion scores and lower inappropriate affect scores than COMT H homozygote. Attention and delusion scores of COMT L allele were higher than COMT H allele. COMT L group had higher aggression than COMT H homozygote. Our results support the theory that COMT L allele was related with increased tonic dopamine activity and cognitive 'stability', which may induce cognitive inflexibility in schizophrenia.