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Institution

Chung-Ang University

EducationSeoul, South Korea
About: Chung-Ang University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Thin film. The organization has 13381 authors who have published 26978 publications receiving 416735 citations. The organization is also known as: CAU & Chung.
Topics: Population, Thin film, Apoptosis, Graphene, Cancer


Papers
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Journal ArticleDOI
TL;DR: Allo‐ASC therapy was safe and effective in improving elbow pain, performance, and structural defects for 52 weeks and is the first to reveal therapeutic value of mesenchymal stem cell injection for treating chronic tendinopathy.
Abstract: Mesenchymal stem cell therapy is a novel regenerative approach for treating tendinopathy. Here, we evaluated the safety and efficacy of allogeneic adipose-derived mesenchymal stem cells (allo-ASC) in treating lateral epicondylosis (LE). Under ultrasound guidance, allo-ASCs mixed with fibrin glue were injected into the hypoechoic common extensor tendon lesions of 12 participants with chronic LE; 6 subjects each were administered 106 or 107 cells in 1 ml. Safety was evaluated at day 3 and weeks 2, 6, 12, 26, and 52 post-injection. Efficacy was assessed by measuring patients’ visual analog scale (VAS) score for elbow pain, modified Mayo clinic performance index for the elbow, and by evaluating longitudinal and transverse ultrasound images of tendon defect areas after 6, 12, 26, and 52 weeks. No significant adverse effects of allo-ASC injection were observed through 52 weeks of follow-up. From baseline through 52 weeks of periodic follow-up, VAS scores progressively decreased from 66.8 ± 14.5 mm to 14.8 ± 13.1 mm and elbow performance scores improved from 64.0 ± 13.5 to 90.6 ± 5.8. Tendon defects also significantly decreased through this period. Allo-ASC therapy was thus safe and effective in improving elbow pain, performance, and structural defects for 52 weeks. This clinical study is the first to reveal therapeutic value of mesenchymal stem cell injection for treating chronic tendinopathy. Stem Cells 2015;33:2995–3005

106 citations

Journal ArticleDOI
TL;DR: Results suggest that 18beta-glycyrrhetinic acid may cause cell death in SiHa cells by inducing the mitochondrial membrane permeability change, leading to cytochrome c release and caspase-3 activation, which may be associated with increased formation of reactive oxygen species and depletion of glutathione.

106 citations

Journal ArticleDOI
Seonhee Park1, Soohwan Yu1, Minseo Kim1, Kwanwoo Park1, Joonki Paik1 
TL;DR: A dual autoencoder network model based on the retinex theory to perform the low-light enhancement and noise reduction by combining the stacked and convolutional autoencoders is presented.
Abstract: This paper presents a dual autoencoder network model based on the retinex theory to perform the low-light enhancement and noise reduction by combining the stacked and convolutional autoencoders. The proposed method first estimates the spatially smooth illumination component which is brighter than an input low-light image using a stacked autoencoder with a small number of hidden units. Next, we use a convolutional autoencoder which deals with 2-D image information to reduce the amplified noise in the brightness enhancement process. We analyzed and compared roles of the stacked and convolutional autoencoders with the constraint terms of the variational retinex model. In the experiments, we demonstrate the performance of the proposed algorithm by comparing with the state-of-the-art existing low-light and contrast enhancement methods.

106 citations

Journal ArticleDOI
TL;DR: The crystal structure of E. coli MacA and the experimentally phased map of Actinobacillus actinomycetemcomitans MacA reveal a domain orientation of MacA different from that of AcrA, which provides insight into the oligomeric state in the functional complex of the drug efflux pump and type I secretion system.

106 citations

Journal ArticleDOI
TL;DR: This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.
Abstract: The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokine (IL-1β , IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0±3.2%), similar to α-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.

106 citations


Authors

Showing all 13500 results

NameH-indexPapersCitations
Carl Nathan13543091535
Scheffer C.G. Tseng9333329213
Richard L. Sidman9329732009
H. Yamaguchi9037533135
Ajith Abraham86111331834
Byung Ihn Choi7860924925
Stefano Soatto7849923597
J. H. Kim7356623052
Daehee Kang7242223959
Lance M. McCracken7228118897
Masanobu Shinozuka6945621961
Seung U. Kim6435514269
Sug Hyung Lee6445421552
Seung U. Kim6312911983
Nam Jin Yoo6340312692
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202362
2022204
20212,535
20202,301
20192,140
20181,991