Institution
Chung-Ang University
Education•Seoul, South Korea•
About: Chung-Ang University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Thin film. The organization has 13381 authors who have published 26978 publications receiving 416735 citations. The organization is also known as: CAU & Chung.
Topics: Population, Thin film, Medicine, Cancer, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors identify relevant lifestyle factors that affect consumer adoption of technology products, and examine the impact of lifestyle factors on perceptio-graphical features of the products.
Abstract: This study aims to identify relevant lifestyle factors that affect consumer adoption of technology products. Furthermore, this study attempts to examine the impact of lifestyle factors on perceptio...
101 citations
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TL;DR: There was a tendency of progressive increase of FI in the muscles with age, which seemed to start from L5-S1 and spread to the upper levels, and the age-dependent fatty degeneration appeared wider in the ES than the MF.
101 citations
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TL;DR: In this article, Al 2 O 3 doped multi-walled carbon nanotubes (MWCNT) were synthesized as a conducting additive in alumina-epoxy terminated poly(dimethylsiloxane) (ETDS).
101 citations
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TL;DR: Mechanistic support is provided for the hypothesis that gestational exposure to BPA alters sperm function and fertility via down-regulation of tyrosine phosphorylation through a PKA-dependent mechanism and the BPA-induced changes in the sperm proteome might be partly responsible for the observed effects in spermatozoa.
Abstract: Background:Maternal exposure to the endocrine disruptor bisphenol A (BPA) has been linked to offspring reproductive abnormalities. However, exactly how BPA affects offspring fertility remains poorl...
101 citations
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TL;DR: The differential activities of FOXL2 and its mutant may partially account for the pathophysiology of GCT development.
Abstract: Some mutations in FOXL2 result in premature ovarian failure accompanied by blepharophimosis, ptosis, epicanthus inversus syndrome type I disease, and FOXL2-null mice exhibit developmental defects in granulosa cells. Recently, FOXL2 c.402C>G, a new somatic mutation that leads to a p.C134W change, was found in the majority of adult-type ovarian granulosa cell tumors (GCTs). In this study, we investigated the possible mechanisms by which the C134W mutation contributes to the development of GCTs. Wild-type (WT) and mutant FOXL2 displayed differential apoptotic activities. Specifically, WT FOXL2 induced significant granulosa cell death, but the mutant exhibited minimal cell death. The FOXL2-induced apoptotic response was greatly dependent on caspase 8, BID and BAK because the depletion of any of these three proteins inhibited FOXL2 from eliciting the full apoptotic response. Activation of caspase 8 and subsequent increased production of truncated BID, and oligomerization of BAK, and release of cytochrome c were all associated with the apoptosis induced by WT FOXL2 expression. In contrast, the mutant FOXL2 was unable to elicit the full array of apoptotic signaling responses. In addition, we found differential TNF-R1 (tumor necrosis factor-receptor 1) and Fas (CD95/APO-1) upregulation between the WT and the mutant, and the silencing of TNF-R1 or Fas and the blockage of the death signaling mediated by TNF-R1 or Fas using TNF-Fc or Fas-Fc, respectively, resulted in significant attenuations of FOXL2-induced apoptosis. Moreover, granulosa cells that expressed either WT FOXL2 or mutant exhibited distinct cell death sensitivities on activation of death receptors and deprivation of serum. Thus, the differential activities of FOXL2 and its mutant may partially account for the pathophysiology of GCT development.
101 citations
Authors
Showing all 13500 results
Name | H-index | Papers | Citations |
---|---|---|---|
Carl Nathan | 135 | 430 | 91535 |
Scheffer C.G. Tseng | 93 | 333 | 29213 |
Richard L. Sidman | 93 | 297 | 32009 |
H. Yamaguchi | 90 | 375 | 33135 |
Ajith Abraham | 86 | 1113 | 31834 |
Byung Ihn Choi | 78 | 609 | 24925 |
Stefano Soatto | 78 | 499 | 23597 |
J. H. Kim | 73 | 566 | 23052 |
Daehee Kang | 72 | 422 | 23959 |
Lance M. McCracken | 72 | 281 | 18897 |
Masanobu Shinozuka | 69 | 456 | 21961 |
Seung U. Kim | 64 | 355 | 14269 |
Sug Hyung Lee | 64 | 454 | 21552 |
Seung U. Kim | 63 | 129 | 11983 |
Nam Jin Yoo | 63 | 403 | 12692 |