Chung-Ang University

About: Chung-Ang University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Thin film. The organization has 13381 authors who have published 26978 publications receiving 416735 citations. The organization is also known as: CAU & Chung.

A feasibility study of laparoscopic total gastrectomy for clinical stage I gastric cancer: a prospective multi-center phase II clinical trial, KLASS 03.

Abstract: With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer. Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled. Twenty-two experienced surgeons from 19 institutions participated in this clinical trial. The primary end point was the incidence of postoperative morbidity and mortality at postoperative 30 days. The severity of postoperative complications was categorized according to Clavien–Dindo classification, and the incidence of postoperative morbidity and mortality was compared with that in a historical control. Of the enrolled patients, 160 met criteria for inclusion in the full analysis set. Postoperative morbidity and mortality rates reached 20.6% (33/160) and 0.6% (1/160), respectively. Fifteen patients (9.4%) had grade III or higher complications, and three reoperations (1.9%) were performed. The incidence of morbidity after LTG in this trial did not significantly differ from that reported in a previous study for open total gastrectomy (18%). LTG performed by experienced surgeons showed acceptable postoperative morbidity and mortality for patients with clinical stage I gastric cancer.

Comparative metabolic and lipidomic profiling of human breast cancer cells with different metastatic potentials

Abstract: // Hye-Youn Kim 1, * , Kyung-Min Lee 1, * , So-Hyun Kim 1 , Yeo-Jung Kwon 1 , Young-Jin Chun 1 , Hyung-Kyoon Choi 1 1 College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea * These authors have contributed equally to this work Correspondence to: Young-Jin Chun, email: yjchun@cau.ac.kr Hyung-Kyoon Choi, email: hykychoi@cau.ac.kr Keywords: metastasis, breast cancer cells, metabolomics, lipidomics, PLSR Received: May 04, 2016 Accepted: August 11, 2016 Published: August 24, 2016 ABSTRACT This study conducted comprehensive and comparative metabolic and lipidomic profiling of a human epithelial breast cell line (MCF-10A), a slightly metastatic (MCF-7), and a highly metastatic (MDA-MB-231) breast cancer cell line using gas chromatography mass spectrometry (GC-MS) and direct infusion mass spectrometry (DI-MS). Among 39 metabolites identified by GC-MS analysis, xanthine, glucose-6-phosphate, mannose-6-phosphate, guanine, and adenine were selected as prognostic markers of breast cancer metastasis. Major metabolic pathways involved in differentiation of the cell lines were alanine, aspartate, and glutamate metabolism, purine metabolism and glycine, serine, and threonine metabolism. Among 44 intact lipid species identified by DI-MS analysis, the levels of most phospholipids were higher in both metastatic groups than in normal cells. Specifically, the levels of phosphatidylserine (PS) 18:0/20:4, phosphatidylinositol (PI) 18:0/20:4, and phosphatidylcholine (PC) 18:0/20:4 were markedly higher while those of phosphatidylethanolamine (PE) 18:1/18:1 and PI 18:0/18:1 were lower in MDA-MB-231 cells than in MCF-7 cells. A partial-least-squares regression model was developed and validated for predicting the metastatic potential of breast cancer cells. The information obtained in this study will be useful when developing diagnostic tools and for identifying potential therapeutic targets for metastatic breast cancer.

Incident Angle- and Polarization-Insensitive Metamaterial Absorber using Circular Sectors

Abstract: In this paper, an incident angle- and polarization-insensitive metamaterial absorber is proposed for X-band applications. A unit cell of the proposed absorber has a square patch at the centre and four circular sectors are rotated around the square patch. The vertically and horizontally symmetric structure of the unit cell enables polarization-insensitivity. The circular sector of the unit cell enables an angle-insensitivity. The performances of the proposed absorber are demonstrated with a full-wave simulation and measurements. The angular sensitivity is studied at different inner angles of the circular sector. When the inner angle of the circular sector is 90°, the simulated absorptivity is higher than 90%, and the frequency variation is less than 0.96% for incident angles up to 70°. The measured absorptivity at 10.44 GHz is close to 100% for all the polarization angles under normal incidence. When the incident angles are varied from 0°– 60°, the measured absorptivity is maintained above 90% for both the transverse electric (TE) and the transverse magnetic (TM) modes.

The Information Content of Trades: An Analysis of KOSPI 200 Index Derivatives

Abstract: This study examines and compares the information content of futures and options trades by analyzing the transaction dataset of derivatives underlying the KOSPI 200 index. This dataset contains detailed information about investor types and trade directions. Previous market microstructure studies of Korea's index derivatives market (i.e., KOSPI 200 futures and options market) may contain model biases and microstructure errors because they depend on structural models and/or they focus on infinitesimal price changes between consecutive trades. In an effort to improve upon previous works, we use the simple regression approach described by Schlag and Stoll (2005, Price impacts of options volume. Journal of Financial Markets, 8, 69–87) and examine the information content of trades by tracing the price impacts of the trades over successive intervals of time. We find that a significant proportion of the price impact attributed to futures trades is permanent and that the price discovery effect is larger in the futures market than in the options market. Institutional futures trades are generally more informative than individual trades, and trades made by foreign institutions have the greatest permanent price impact. Examination of the intertemporal relationship between futures and options trades also indicates that the futures trades generally lead the options trades. Overall our results suggest that futures trades contribute more to price discovery than do options trades and that futures trades made by foreign institutions are most informed while those of domestic individuals are least informed. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark 35:201–221, 2015