Chung Yuan Christian University

About: Chung Yuan Christian University is a education organization based out in Taoyuan City, Taiwan. It is known for research contribution in the topics: Membrane & Fuzzy logic. The organization has 9819 authors who have published 11623 publications receiving 213139 citations. The organization is also known as: Tiong-gôan-tāi-ha̍k & CYCU.

A review of empirical evidence on scaffolding for science education

Abstract: This content analysis of articles in the Social Science Citation Index journals from 1995 to 2009 was conducted to provide science educators with empirical evidence regarding the effects of scaffolding on science learning. It clarifies the definition, design, and implementation of scaffolding in science classrooms and research studies. The results show important cross-study evidence that most researchers have adopted a qualitative approach (67.44%), focused on learning context (72.09%), and used high school students as participants (53.49%). In designing scaffoldings, researchers have shown a preference for long-term explicit scaffolding using multiple representations to promote procedural and strategic skills and alternative assessments of learner performance. Nevertheless, scaffolding issues related to teacher education are unexpectedly few (11.63%) in empirical research. The results also indicate that there are too few studies to guide researchers in considering fading scaffolds for active learning (9.30%). Future directions and suggestions toward conducting research regarding scaffolding are provided.

DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice.

Abstract: Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could play an important role in the initiation and progression of colon cancer. Curcumin, a dietary phytochemical, shows promising effects in suppressing colitis-associated colon cancer in azoxymethane-dextran sulfate sodium (AOM-DSS) mice. However, the potential epigenetic mechanisms of curcumin in colon cancer remain unknown. In this study, the anticancer effect of curcumin in suppressing colon cancer in an 18-week AOM-DSS colon cancer mouse model was confirmed. We identified lists of differentially expressed and differentially methylated genes in pairwise comparisons and several pathways involved in the potential anticancer effect of curcumin. These pathways include LPS/IL-1-mediated inhibition of RXR function, Nrf2-mediated oxidative stress response, production of NO and ROS in macrophages and IL-6 signaling. Among these genes, Tnf stood out with decreased DNA CpG methylation of Tnf in the AOM-DSS group and reversal of the AOM-DSS induced Tnf demethylation by curcumin. These observations in Tnf methylation correlated with increased and decreased Tnf expression in RNA-seq. The functional role of DNA methylation of Tnf was further confirmed by in vitro luciferase transcriptional activity assay. In addition, the DNA methylation level in a group of inflammatory genes was decreased in the AOM+DSS group but restored by curcumin and was validated by pyrosequencing. This study shows for the first time epigenomic changes in DNA CpG methylation in the inflammatory response from colitis-associated colon cancer and the reversal of their CpG methylation changes by curcumin. Future clinical epigenetic studies with curcumin in inflammation-associated colon cancer would be warranted.

Fundamentals and applications of zwitterionic antifouling polymers

Abstract: Zwitterionic materials as a new class of emerging materials have recently been developed and applied to a broad range of biomedical and engineering applications. Zwitterionic materials possess a unique molecular structure combining both cationic and anionic groups with overall charge neutrality and high hydrophilicity. In this review, we first provide the structure-property relationship of the zwitterionic materials at molecular level, from a molecular simulation viewpoint. Then, we discuss the recent experimental developments in the preparation, properties, and applications of zwitterionic materials, with a particular focus on their antifouling properties on coating surfaces and with additional functionality and applications. Finally, we offer our personal viewpoint of current challenges and future directions in this emerging area. Our goal is to introduce the current status of this type of new zwitterionic materials to researchers from different areas and motivate them to explore all the potentials.