Institution
Chung Yuan Christian University
Education•Taoyuan City, Taiwan•
About: Chung Yuan Christian University is a education organization based out in Taoyuan City, Taiwan. It is known for research contribution in the topics: Membrane & Fuzzy logic. The organization has 9819 authors who have published 11623 publications receiving 213139 citations. The organization is also known as: Tiong-gôan-tāi-ha̍k & CYCU.
Topics: Membrane, Fuzzy logic, Control theory, Adsorption, Photoluminescence
Papers published on a yearly basis
Papers
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TL;DR: Chitosan (CS) nanofibers were prepared by an electrospinning technique and then treated with simulated body fluid (SBF) to encourage hydroxyapatite (HA) formation on their surface.
Abstract: Chitosan (CS) nanofibers were prepared by an electrospinning technique and then treated with simulated body fluid (SBF) to encourage hydroxyapatite (HA) formation on their surface. The CS/HA nanofibers were subjected to scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy, and X-ray diffraction (XRD) to confirm HA formation as well as determine the morphology of the nanofibrous scaffolds. The SEM image indicated that the distribution of HA on the CS nanofibers was homogeneous. The results from EDS and XRD indicated that HA was formed on the nanofibrous surfaces after 6-day incubation in the SBF. The calcium/phosphorus ratio of deposited HA was close to that of natural bone. To determine biocompatibility, the CS/HA scaffolds were applied to the culture of rat osteosarcoma cell lines (UMR-106). The cell densities on the CS/HA nanofibers were higher than those on the CS nanofibers, the CS/HA film, and the CS film, indicating that cell proliferation on CS/HA nanofibers was enhanced. Moreover, the early osteogenic differentiation on CS/HA was also more significant, due to the differences in chemical composition and the surface area of CS/HA nanofibers. The biocompatibility and the cell affinity were enhanced using the CS/HA nanofibers. This indicates that electrospun CS/HA scaffolds would be a potential material in bone tissue engineering.
66 citations
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TL;DR: In this paper, a low-temperature solution-processable bismuth iodide (BiI3) nanosheets were used as hole transport layers in organic photovoltaics with an active layer comprising poly(3hexylthiophene) (P3HT) mixed with a fullerene derivative.
66 citations
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TL;DR: Experimental results indicate that the proposed F-SVDD ensemble not only greatly improves the performance of SVDD, but also outperforms other commonly used classifiers such as support vector machine (SVM), in terms of target defect identification rate.
Abstract: Inline defect inspection plays a critical role in yield improvement for thin film transistor liquid crystal display (TFT-LCD) manufacturing. In array process, some defects are critical to the quality of LCD panels (target defects), while some are not (non-target defects). This paper proposes a target defect identification system by which the target defects can be automatically identified. The proposed system is composed of five parts: projection-based pixel segmentation, normal pixel removal, feature extraction, target defect identification, and decision making. For the identifier design, a novel one-class kernel classifier called fuzzy support vector data description (F-SVDD) ensemble is proposed. F-SVDD ensemble is proposed to solve two critical problems existing in SVDD, including the overfitting due to outliers, and the multi-cluster distribution. In F-SVDD ensemble, both the best number of the F-SVDD members in the ensemble and the elements of each member can be determined by using partitioning-entropy-based kernel fuzzy c-means (KFCM) algorithm. Experimental results, carried out by real defective images provided by a LCD manufacturer, indicate that the proposed F-SVDD ensemble not only greatly improves the performance of SVDD, but also outperforms other commonly used classifiers such as support vector machine (SVM), in terms of target defect identification rate. In addition, the task of target defect identification for one defective image can be accomplished within 3s by the proposed system.
66 citations
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TL;DR: In this article, a number of novel polyaspartimides were successfully synthesized via Michael addition reactions involving phosphorus-containing diamines and bismaleimides as monomers and using p-toluenesulfonic acid and N-N-dimethylacetamide as a catalyst and a solvent, respectively.
66 citations
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TL;DR: GEH NPs are potentially valuable as a new therapeutic agent delivered in eye drops for treating DES and were successfully produced with high affinity for HCECs and animal eyes.
Abstract: Introduction Dry-eye syndrome (DES) is a general eye disease. Eye drops are the common ophthalmological medication. However, the ocular barrier makes it difficult to attain high drug bioavailability. Nanomedicine is a promising alternative treatment for ocular diseases and may increase drug content in the affected eye. Methods To explore this potential, we constructed nanoparticles (NPs) containing an anti-inflammatory agent for DES treatment. The NPs were made of gelatin-epigallocatechin gallate (EGCG) with surface decoration by hyaluronic acid (HA) and designated "GEH". The particle size, surface charge, and morphology were evaluated. The in vitro biocompatibility and anti-inflammation effect of nanoparticles were assayed via culturing with human corneal epithelium cells (HCECs) and in vivo therapeutic effect was examined in a DES rabbit's model. Results The synthesized GEH NPs had a diameter of approximately 250 nm and were positively charged. A coculture experiment revealed that 20 µg/mL GEH was not cytotoxic to HCECs and that an EGCG concentration of 0.2 µg/mL downregulated the gene expression of IL1B and IL6 in inflamed HCECs. Large amounts of GEH NPs accumulated in the cytoplasm of HCECs and the ocular surfaces of rats and rabbits, indicating the advantage of GEH NPs for ocular delivery of medication. Twice-daily topical treatment with GEH NPs was performed in a rabbit model of DES. The ocular surface of GEH-treated rabbits displayed normal corneal architecture with no notable changes in inflammatory cytokine levels in the cornea lysate. The treatment improved associated clinical signs, such as tear secretion, and fluorescein staining recovered. Conclusion We successfully produced GEH NPs with high affinity for HCECs and animal eyes. The treatment can be delivered as eye drops, which retain the drug on the ocular surface for a longer time. Ocular inflammation was effectively inhibited in DES rabbits. Therefore, GEH NPs are potentially valuable as a new therapeutic agent delivered in eye drops for treating DES.
66 citations
Authors
Showing all 9844 results
Name | H-index | Papers | Citations |
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Simon Lin | 126 | 754 | 69084 |
Xiaodong Li | 104 | 1300 | 49024 |
Yu Wang | 92 | 1687 | 47472 |
Leaf Huang | 92 | 350 | 25867 |
Duu-Jong Lee | 91 | 979 | 37292 |
Yen Wei | 85 | 649 | 25805 |
Ru-Shi Liu | 82 | 738 | 26699 |
Kazuhiko Ishihara | 77 | 713 | 24795 |
Gwo-Hshiung Tzeng | 77 | 465 | 26807 |
Huan-Tsung Chang | 76 | 405 | 21476 |
Hari M. Srivastava | 76 | 1126 | 42635 |
Jianhua Yang | 74 | 554 | 27839 |
Yen Wei | 68 | 309 | 17527 |
Hsisheng Teng | 67 | 213 | 14408 |
Kevin C.-W. Wu | 66 | 278 | 15193 |