Chung Yuan Christian University

About: Chung Yuan Christian University is a education organization based out in Taoyuan City, Taiwan. It is known for research contribution in the topics: Membrane & Fuzzy logic. The organization has 9819 authors who have published 11623 publications receiving 213139 citations. The organization is also known as: Tiong-gôan-tāi-ha̍k & CYCU.

Paths to globally generalized synchronization in scale-free networks.

Abstract: We apply the auxiliary-system approach to study paths to globally generalized synchronization in scale-free networks of identical chaotic oscillators, including H\'enon maps, logistic maps, and Lorentz oscillators. As the coupling strength $\ensuremath{\epsilon}$ between nodes of the network is increased, transitions from partially to globally generalized synchronization and intermittent behaviors near the synchronization thresholds, are found. The generalized synchronization starts from the hubs of the network and then spreads throughout the whole network with the increase of $\ensuremath{\epsilon}$. Our result is useful for understanding the synchronization process in complex networks.

Internet Traffic Classification for Scalable QOS Provision

Abstract: A new scheme that classifies the Internet traffic according to their application types for scalable QoS provision is proposed in this work The traditional port-based classification method does not yield satisfactory performance, since the same port can be shared by multiple applications Furthermore, asymmetric routing and errors of modern measurement tools such as PCF and NetFlow degrades the classification performance To address these issues, the proposed classification process consists of two steps: feature selection and classification Candidate features that can be obtained easily by ISP are examined Then, we perform feature reduction so as to balance the performance and complexity As to classification, the REPTree and the bagging schemes are adopted and compared It is demonstrated by simulations with real data that the proposed classification scheme outperforms existing techniques

Feasibility study of using high-frequency ultrasonic Nakagami imaging for characterizing the cataract lens in vitro.

Abstract: A cataract is a clouding of the crystalline lens that reduces the amount of incoming light and impairs visual perception. Phacoemulsification is the most common surgical method for treating advanced cataracts, and determining the optimal phacoemulsification energy is dependent on measuring the hardness of the lens. This study explored the feasibility of using an ultrasonic parametric image based on the Nakagami distribution to quantify the lens hardness. Young's modulus was measured in porcine lenses in which cataracts had been artificially induced. High-frequency ultrasound at 35 MHz was used to obtain the B-mode and Nakagami images of the cataract lenses. The averaged integrated backscatter and Nakagami parameters were also estimated in the region of interest. The experimental results show that the conventional B-scan and integrated backscatter are inadequate for quantifying the lens hardness, whereas Nakagami imaging allows different degrees of lens hardening to be distinguished both globally and locally based on the concentration of fiber coemption therein.

Effects of low-intensity pulsed ultrasound, dexamethasone/TGF-β1 and/or BMP-2 on the transcriptional expression of genes in human mesenchymal stem cells: Chondrogenic vs. osteogenic differentiation

Abstract: The effects of low-intensity pulsed ultrasound (LIPUS) on the differentiation of human mesenchymal stem cells (hMSCs) were investigated in this study. hMSCs were subjected to LIPUS with or without dexamethasone/transforming growth factor-beta1 (TD) or bone morphogenetic protein-2 (BMP-2) and the effects of this treatment were assessed. TD-treated hMSCs exhibited characteristic chondrogenic morphology and increased messenger RNA (mRNA) expression of chondrogenic markers and LIPUS enhanced the chondrogenic differentiation of hMSCs treated with TD. The expression of Runx2, an osteogenic transcription factor was not altered in either TD treatment group; however, a significant increase was detected in the LIPUS only group. The osteogenic appearance exhibited 3 days after LIPUS and/or BMP-2 treatment. Increases in the mRNA expression levels of osteogenic markers, Runx2 and ALP were also detected. There was no additive or altered effect with combined LIPUS and BMP-2 treatment. LIPUS alone can increase osteogenic differentiation of hMSCs and LIPUS enhances TD-mediated chondrogenic differentiation of hMSCs. Clinically, LIPUS may differentially influence bone vs. cartilage repair.

Fluorescent Carbon Dots for Selective Labeling of Subcellular Organelles

Abstract: With the recent advancement in understanding and control of the structure and optical properties of fluorescent carbon dots (CDs), they have been shown to be valuable in biolabeling of bacteria, tumor cells, tissues, and organelles. Their extremely small size and tunable functional properties coupled with ultrastable fluorescence enable CDs to be used for easy and effective labeling of various organelles. In addition, CDs with advantages of easy preparation and functionalization with recognition elements and/or drugs have emerged as nanocarriers for organelle-targeted drug delivery. In this review, we mainly discuss the applications of fluorescent CDs for the labeling of organelles, including lysosome, nucleoli, nucleus, endoplasmic reticulum, and mitochondria. We highlight the importance of the surface properties (functional groups, hydrophobicity/hydrophilicity, charges, zwitterions) and the size of CDs for labeling. Several interesting examples are provided to highlight the potential and disadvantages of CDs for labeling organelles. Strategies for the preparation of CDs for specific labeling of organelles are suggested. With the edge in preparation of diverse CDs, their potential in labeling and drug delivery is highly expected.