Chung Yuan Christian University

About: Chung Yuan Christian University is a education organization based out in Taoyuan City, Taiwan. It is known for research contribution in the topics: Membrane & Fuzzy logic. The organization has 9819 authors who have published 11623 publications receiving 213139 citations. The organization is also known as: Tiong-gôan-tāi-ha̍k & CYCU.

Synthesis and Characterization of Antifouling Poly(N-acryloylaminoethoxyethanol) with Ultralow Protein Adsorption and Cell Attachment

Abstract: Rational design of effective antifouling polymers is challenging but important for many fundamental and applied applications. Herein we synthesize and characterize an N-acryloylaminoethoxyethanol (AAEE) monomer, which integrates three hydrophilic groups of hydroxyl, amide, and ethylene glycol in the same material. AAEE monomers were further grafted and polymerized on gold substrates to form polyAAEE brushes with well-controlled thickness via surface-initiated atomic transfer radical polymerization (SI-ATRP), with particular attention to a better understanding of the molecular structure–antifouling property relationship of hydroxyl-acrylic-based polymers. The surface hydrophilicity and antifouling properties of polyAAEE brushes as a function of film thickness are studied by combined experimental and computational methods including surface plasmon resonance (SPR) sensors, atomic force microscopy (AFM), cell adhesion assay, and molecular dynamics (MD) simulations. With the optimal polymer film thicknesses (∼...

Solubility of Nitrous Oxide in Alkanolamine Aqueous Solutions

Abstract: The solubility of nitrous oxide (N2O) in alkanolamine aqueous solutions has been measured at (30, 35, and 40) °C. The systems studied are monoethanolamine, diethanolamine, diisopropanolamine, triethanolamine, and 2-amino-2-methyl-1-propanol aqueous solutions. The concentration of amine for monoethanolamine ranges from (1 to 6) kmol·m-3 and for other amines from (0.5 to 3) kmol·m-3. The accuracy of the measurement is estimated to be ± 2%. A semiempirical model of the excess Henry's constant proposed by Wang et al. (1992) was used to correlate the solubility of N2O in amine solutions. The parameters of the correlation were determined from the measured solubility data and the available data in the open literature. For a wide temperature range from (15 to 75) °C, the obtained correlation has been shown to represent reasonably the solubility of N2O in six amine aqueous solutions: MEA, DEA, DIPA, TEA, MDEA, and AMP. For the purpose of process design, the obtained correlations are, in general, satisfactory for ...

Cytotoxic effects of CdSe quantum dots on maturation of mouse oocytes, fertilization, and fetal development.

Abstract: Quantum dots (QDs) are useful novel luminescent markers, but their embryonic toxicity is yet to be fully established, particularly in oocyte maturation and sperm fertilization. Earlier experiments by our group show that CdSe-core QDs have cytotoxic effects on mouse blastocysts and are associated with defects in subsequent development. Here, we further investigate the influence of CdSe-core QDs on oocyte maturation, fertilization, and subsequent pre- and postimplantation development. CdSe-core QDs induced a significant reduction in the rates of oocyte maturation, fertilization, and in vitro embryo development, but not ZnS-coated CdSe QDs. Treatment of oocytes with 500 nM CdSe-core QDs during in vitro maturation (IVM) led to increased resorption of postimplantation embryos and decreased placental and fetal weights. To our knowledge, this is the first study to report the negative impact of CdSe-core QDs on mouse oocyte development. Moreover, surface modification of CdSe-core QDs with ZnS effectively prevented this cytotoxicity.