Clemson University

About: Clemson University is a education organization based out in Clemson, South Carolina, United States. It is known for research contribution in the topics: Population & Control theory. The organization has 20556 authors who have published 42518 publications receiving 1170779 citations. The organization is also known as: Clemson Agricultural College of South Carolina.

A New Way of Using ac Voltammetry To Study Redox Kinetics in Electroactive Monolayers

Abstract: A new protocol for analyzing variable-frequency ac voltammetry (acv) data to obtain electron-transfer rate constants for redox-active groups immobilized in monolayer films on electrodes is described. The protocol involves plotting the ratio of the peak current to the background current as a function of the log of frequency and then fitting the plot to a calculated curve obtained using the Randles equivalent circuit model. The fitting procedure is particularly straightforward since it involves just two adjustable fitting parameters and can usually be performed manually in a spreadsheet. Advantages of the new method include the following: (1) it requires fewer adjustable fitting parameters than the conventional impedance analysis performed in the complex-plane format; (2) because there are fewer fitting parameters, there is less chance of the fit yielding a false convergence; (3) nonideal effects associated with a distribution of rate constants are apparently revealed in a particularly intuitive and easily...

Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes

Abstract: During the development of new nonsteroidal anti-inflammatory agents, it was discovered that 1-aminoalkyl-3-aroylindoles have affinity for the cannabinoid brain (CB(1)) receptor. This has led to the development of over 100 cannabimimetic aminoalkylindoles, and the development of SAR for these compounds. Later work demonstrated that the aminoalkyl moiety was not necessary, and could be replaced by a four- to six-membered alkyl chain without loss of affinity. Investigation of these indoles led to the discovery of a CB(2) selective ligand, 3-(1-naphthoyl)-N-propylindole. Subsequent work has provided several additional CB(2) selective indoles. On the basis of a proposed pharmacophore for the cannabimimetic indoles, a series of pyrroles and indenes were developed, some of which are potent cannabinoids. SAR for several series of pyrroles have been developed. Two groups have described cannabimimetic indenes, which have been employed as rigid models for the receptor interactions of cannabimimetic indoles with the CB(1) receptor. There is some evidence that the indoles bind to a somewhat different site on the receptor than traditional cannabinoids, and interact with the receptor primarily by aromatic stacking.