Clemson University

About: Clemson University is a education organization based out in Clemson, South Carolina, United States. It is known for research contribution in the topics: Population & Control theory. The organization has 20556 authors who have published 42518 publications receiving 1170779 citations. The organization is also known as: Clemson Agricultural College of South Carolina.

Constraint-based automatic test data generation

Abstract: A novel technique for automatically generating test data is presented. The technique is based on mutation analysis and creates test data that approximate relative adequacy. It is a fault-based technique that uses algebraic constraints to describe test cases designed to find particular types of faults. A set of tools (collectively called Godzilla) that automatically generates constraints and solves them to create test cases for unit and module testing has been implemented. Godzilla has been integrated with the Mothra testing system and has been used as an effective way to generate test data that kill program mutants. The authors present an initial list of constraints and discuss some of the problems that have been solved to develop the complete implementation of the technique. >

Advances toward bioapplications of carbon nanotubes

Abstract: Bioapplications of carbon nanotubes have been predicted and explored ever since the discovery of these one-dimensional carbon allotropes. Indeed, carbon nanotubes have many interesting and unique properties potentially useful in a variety of biological and biomedical systems and devices. Significant progress has been made in the effort to overcome some of the fundamental and technical barriers toward bioapplications, especially on issues concerning the aqueous solubility and biocompatibility of carbon nanotubes and on the design and fabrication of prototype biosensors. In this article we take a comprehensive look at the advances in this fast-moving and exciting research field. We review the current status of available methodologies for the aqueous dispersion and solubilization of carbon nanotubes, discuss the results on modifications of carbon nanotubes with various biological and bioactive species, and highlight some of the recent achievements in the fabrication and evaluation of carbon nanotube-based bioanalytical devices.

Carbon Dots as Nontoxic and High-Performance Fluorescence Imaging Agents

Abstract: Fluorescent carbon dots (small carbon nanoparticles with the surface passivated by oligomeric PEG molecules) were evaluated for their cytotoxicity and in vivo toxicity and also for their optical imaging performance in reference to that of the commercially supplied CdSe/ZnS quantum dots. The results suggested that the carbon dots were biocompatible, and their performance as fluorescence imaging agents was competitive. The implication to the use of carbon dots for in vitro and in vivo applications is discussed.