Clemson University

About: Clemson University is a education organization based out in Clemson, South Carolina, United States. It is known for research contribution in the topics: Population & Control theory. The organization has 20556 authors who have published 42518 publications receiving 1170779 citations. The organization is also known as: Clemson Agricultural College of South Carolina.

Effect of microencapsulation on viability and other characteristics in Lactobacillus acidophilus ATCC 43121

Abstract: Lactobacillus acidophilus ATCC 43121 were microencapsulated with sodium alginate by dropping method. The effects of microencapsulation on the changes in survival rate of the L. acidophilus ATCC 43121 during exposure to artificial gastrointestinal and on the change in heat susceptibility of L. acidophilus ATCC 43121 during the heat treatment were studied. In addition, cholesterol assimilation and intestinal adhesion of non-encapsulated and encapsulated L. acidophilus ATCC 43121 were also investigated to explore the effect of microencapsulation on health beneficial effect of lactic acid bacteria. Non-encapsulated cells were completely destroyed when exposed to artificial gastric juice (AGJ) of pH 1.2 and 1.5, while the treatment declined the viable count of encapsulated samples only by 3 log. Encapsulated cells exhibited a significantly higher resistance to artificial intestinal juice (AIJ) and heat treatment than non-encapsulated samples. The assimilative reductions of cholesterol by non-encapsulated and encapsulated L. acidophilus ATCC 43121 were 35.98% and 32.84%, respectively. However, encapsulation did not significantly (P>0.05) affect the adherence of L. acidophilus ATCC 43121 onto the human intestinal epithelial cell lines HT-29. The microencapsulation effectively protected the microorganisms from heat and acid treatment in delivering the viable cells to intestine without any significant adverse effect on their functionalities.

Effects of spaceflight on murine skeletal muscle gene expression

Abstract: Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and shifts toward faster muscle fiber types. To identify changes in gene expression that may underlie these adaptations, we used both microarray expression analysis and real-time polymerase chain reaction to quantify shifts in mRNA levels in the gastrocnemius from mice flown on the 11-day, 19-h STS-108 shuttle flight and from normal gravity controls. Spaceflight data also were compared with the ground-based unloading model of hindlimb suspension, with one group of pure suspension and one of suspension followed by 3.5 h of reloading to mimic the time between landing and euthanization of the spaceflight mice. Analysis of microarray data revealed that 272 mRNAs were significantly altered by spaceflight, the majority of which displayed similar responses to hindlimb suspension, whereas reloading tended to counteract these responses. Several mRNAs altered by spaceflight were associated with muscle growth, including the phosphatidylinositol 3-kinase regulatory subunit p85α, insulin response substrate-1, the forkhead box O1 transcription factor, and MAFbx/atrogin1. Moreover, myostatin mRNA expression tended to increase, whereas mRNA levels of the myostatin inhibitor FSTL3 tended to decrease, in response to spaceflight. In addition, mRNA levels of the slow oxidative fiber-associated transcriptional coactivator peroxisome proliferator-associated receptor (PPAR)-γ coactivator-1α and the transcription factor PPAR-α were significantly decreased in spaceflight gastrocnemius. Finally, spaceflight resulted in a significant decrease in levels of the microRNA miR-206. Together these data demonstrate that spaceflight induces significant changes in mRNA expression of genes associated with muscle growth and fiber type.

Optimal speed advisory for connected vehicles in arterial roads and the impact on mixed traffic

Abstract: Connected Vehicles (CV) equipped with a Speed Advisory System (SAS) can obtain and utilize upcoming traffic signal information to manage their speed in advance, lower fuel consumption, and improve ride comfort by reducing idling at red lights. In this paper, a SAS for pre-timed traffic signals is proposed and the fuel minimal driving strategy is obtained as an analytical solution to a fuel consumption minimization problem. We show that the minimal fuel driving strategy may go against intuition of some people; in that it alternates between periods of maximum acceleration, engine shut down, and sometimes constant speed, known in optimal control as bang-singular-bang control. After presenting this analytical solution to the fuel minimization problem, we employ a sub-optimal solution such that drivability is not sacrificed and show fuel economy still improves significantly. Moreover this paper evaluates the influence of vehicles with SAS on the entire arterial traffic in micro-simulations. The results show that SAS-equipped vehicles not only improve their own fuel economy, but also benefit other conventional vehicles and the fleet fuel consumption decreases with the increment of percentage of SAS-equipped vehicles. We show that this improvement in fuel economy is achieved with a little compromise in average traffic flow and travel time.

Design and implementation of a multi-section continuum robot: Air-Octor

Abstract: In this paper, we describe the design and implementation of a novel multi-section, continuous-backbone ("continuum") robot. The design is based on an innovative "hose-in-hose" concept. Its implementation is novel with respect to previous continuum robot designs in that stiffness and extension, in addition to bending, are actively controlled in each section of the robot. This requires a non-trivial extension of previously proposed kinematic models, and poses challenges for real-time control of the robot. We introduce a tangling/untangling algorithm to map between overall cable lengths and per-section cable lengths. Details of the design and its implementation are presented, along with a summary of real-time control issues and experimental results.