Institution
Clemson University
Education•Clemson, South Carolina, United States•
About: Clemson University is a education organization based out in Clemson, South Carolina, United States. It is known for research contribution in the topics: Population & Control theory. The organization has 20556 authors who have published 42518 publications receiving 1170779 citations. The organization is also known as: Clemson Agricultural College of South Carolina.
Topics: Population, Control theory, Poison control, Optical fiber, Fiber
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors investigate the control framework that results from a lean manufacturing strategic initiative and develop a theoretical framework that assists in understanding the control choices, accounting practices, and organizational structure associated with lean manufacturing.
190 citations
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University of Udine1, University of Paris-Sud2, University of Mainz3, Centre national de la recherche scientifique4, University College Dublin5, University of Geneva6, Autonomous University of Barcelona7, Technical University of Denmark8, Goddard Space Flight Center9, Polish Academy of Sciences10, University of Padua11, Clemson University12, University of Urbino13, Yale University14, Max Planck Society15, University of Erlangen-Nuremberg16, Brera Astronomical Observatory17, United States Naval Research Laboratory18, University of Tokyo19, PSL Research University20, University of Trieste21, University of Würzburg22, University of Maryland, College Park23, University of Barcelona24, Scuola Normale Superiore di Pisa25, University of Potsdam26, Rovira i Virgili University27, University of Coimbra28, University College London29, University of California, Berkeley30
TL;DR: The e-ASTROGAM (enhanced ASTROGAM) project as mentioned in this paper is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV.
Abstract: e-ASTROGAM (‘enhanced ASTROGAM’) is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV – the lower energy limit can be pushed to energies as low as 150 keV, albeit with rapidly degrading angular resolution, for the tracker, and to 30 keV for calorimetric detection. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LIGO-Virgo-GEO600-KAGRA, SKA, ALMA, E-ELT, TMT, LSST, JWST, Athena, CTA, IceCube, KM3NeT, and the promise of eLISA.
190 citations
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TL;DR: In this article, the authors identify and test key factors that can be associated with time to recall a product and their relationship with recall strategies, source of the defect and supply chain position of the recalling firm.
190 citations
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TL;DR: The effects of CB2 receptor agonists on TNF‐α‐induced proliferation, migration and signal transduction in human coronary artery smooth muscle cells (HCASMCs) are investigated.
Abstract: Background and purpose:
Vascular smooth muscle proliferation and migration triggered by inflammatory stimuli are involved in the development and progression of atherosclerosis and restenosis. Cannabinoids may modulate cell proliferation in various cell types through cannabinoid 2 (CB2) receptors. Here, we investigated the effects of CB2 receptor agonists on TNF-α-induced proliferation, migration and signal transduction in human coronary artery smooth muscle cells (HCASMCs).
Experimental approach:
HCASMCs were stimulated with TNF-α. Smooth muscle proliferation was determined by the extent of BrdU incorporation and the migration was assayed by modified Boyden chamber. CB2 and/or CB1 receptor expressions were determined by immunofluorescence staining, western blotting, RT-PCR, real-time PCR and flow cytometry.
Key results:
Low levels of CB2 and CB1 receptors were detectable in HCASMCs compared to the high levels of CB2 receptors expressed in THP-1 monocytes. TNF-α triggered up to ∼80% increase (depending on the method used) in CB2 receptor mRNA and/or protein expression in HCASMCs, and induced Ras, p38 MAPK, ERK 1/2, SAPK/JNK and Akt activation, while increasing proliferation and migration. The CB2 agonists, JWH-133 and HU-308, dose-dependently attenuated these effects of TNF-α.
Conclusions and implications:
Since the above-mentioned TNF-α-induced phenotypic changes are critical in the initiation and progression of atherosclerosis and restenosis, our findings suggest that CB2 agonists may offer a novel approach in the treatment of these pathologies by decreasing vascular smooth muscle proliferation and migration.
British Journal of Pharmacology (2008) 153, 347–357; doi:10.1038/sj.bjp.0707569; published online 12 November 2007
189 citations
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TL;DR: This article proposes a framework to infuse a unique human-like ability, building and actively repairing trust, into autonomous systems, and proposes a model to guide the design of future autonomy.
Abstract: Modern interactions with technology are increasingly moving away from simple human use of computers as tools to the establishment of human relationships with autonomous entities that carry out acti...
189 citations
Authors
Showing all 20718 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yury Gogotsi | 171 | 956 | 144520 |
Philip S. Yu | 148 | 1914 | 107374 |
Aaron Dominguez | 147 | 1968 | 113224 |
Danny Miller | 133 | 512 | 71238 |
Marco Ajello | 131 | 535 | 58714 |
David C. Montefiori | 129 | 920 | 70049 |
Frank L. Lewis | 114 | 1045 | 60497 |
Jianqing Fan | 104 | 488 | 58039 |
Wei Chen | 103 | 1438 | 44994 |
Ken A. Dill | 99 | 401 | 41289 |
Gerald Schubert | 98 | 614 | 34505 |
Rod A. Wing | 98 | 333 | 47696 |
Feng Chen | 95 | 2138 | 53881 |
Jimin George | 94 | 331 | 62684 |
François Diederich | 93 | 843 | 46906 |