Showing papers by "Clinical Trial Service Unit published in 1988"
TL;DR: Most deep-vein thromboses are subclinical and resolve completely when mobility is restored, although some do produce permanent valvular damage and chronic venous insufficiency, and a few, however, may travel to the lungs and, depending on how much of the pulmonary circulation is.
Abstract: DURING prolonged general anesthesia and any period of limited mobility following surgery, thrombus formation may be initiated in the deep veins of the legs. Studies employing Radio-labeled fibrinogen or venography have revealed deep-vein thrombosis in 20 to 30 percent of patients who have undergone general surgery and in an even larger proportion of patients who have had orthopedic surgery.1 2 3 Most such thromboses are subclinical and resolve completely when mobility is restored, although some do produce permanent valvular damage and chronic venous insufficiency. A few, however, may travel to the lungs and, depending on how much of the pulmonary circulation is . . .
1,203 citations
TL;DR: The greatest reduction in mortality occurred during the first week or so of follow-up, with a non-significant further reduction after this early period, suggesting that the early benefit is not rapidly lost.
359 citations
TL;DR: There were no significant correlations between the immunological markers and complete remission rate, duration of remission, or survival.
Abstract: Mononuclear cells from peripheral blood or bone marrow from 314 patients with acute myeloid leukaemia were examined for the presence of nuclear terminal deoxynucleotidyl transferase (304 patients), surface membrane expression of HLA-DR (314 patients) and the common acute lymphoblastic leukaemia antigen (281 patients). All patients were treated with identical remission induction chemotherapy, and morphological diagnosis was carried out in a central laboratory. The overall complete remission rate was 70%. There were no significant correlations between the immunological markers and complete remission rate, duration of remission, or survival.
20 citations
TL;DR: Marrow smears from entrants to the Medical Research Council trial UKALL VIII, other than those from children with B‐ALL, were studied prospectively for the presence or absence of blast cell vacuoles and for any clinical or biological relevance this feature might have.
Abstract: As part of a central review of cell morphology in childhood lymphoblastic leukaemia (ALL), marrow smears from entrants to the Medical Research Council trial UKALL VIII, other than those from children with B-ALL, were studied prospectively for the presence or absence of blast cell vacuoles and for any clinical or biological relevance this feature might have. Adequate slides were available from 733 patients (88% of the trial entrants) after five with B ALL were excluded. Vacuolated blast cells (greater than 10%) were present in 204 (28%). The presence of vacuoles was associated with PAS positivity (chi 2 = 27.8; P less than 0.0001), a diagnostic white cell count (WBC) less than 50 x 10(9)/l (chi 2 = 13.1; P less than 0.0001), and the immunophenotype of 'common' ALL (CD10 positive) (chi 2 = 9.1; P less than 0.01). There was no clear association with French-American-British (FAB) type L1 or L2. The 204 patients with vacuoles had a significantly superior disease free survival compared to the remainder (2P = 0.01), a difference which remained significant when the analysis was stratified by FAB type (2P = 0.01), age (2P = 0.02) or sex (2P = 0.02), but which was lost when stratified by WBC (2P = 0.06). These findings provide further evidence that, outside the context of B-ALL, vacuoles are indicative of a relatively benign disease which responds well to therapy. The French-American-British (FAB) classification should be modified to take this into account.
20 citations