Clinical Trial Service Unit

About: Clinical Trial Service Unit is a based out in . It is known for research contribution in the topics: Population & Stroke. The organization has 428 authors who have published 1387 publications receiving 181920 citations.

Social inequalities, tobacco chewing, and cancer mortality in south India: a case-control analysis of 2,580 cancer deaths among non-smoking non-drinkers.

Abstract: Objective The objective of this work was to describe the relationships between educational level, tobacco chewing, and cancer mortality in south India, among middle-aged adults who never smoked tobacco or drank alcohol, to eliminate confounding by those habits.

Reducing recurrent stroke: Methodology of the motivational interviewing in stroke (MIST) randomized clinical trial

Abstract: RationaleRecurrent stroke is prevalent in both developed and developing countries, contributing significantly to disability and death. Recurrent stroke rates can be reduced by adequate risk factor ...

Leukoaraiosis at Presentation and Disease Progression during Follow-up in Histologically Confirmed Cases of Dementia

Abstract: While Alzheimer’s disease and vascular dementia have distinct histopathological features, the combination of both may result in more severe symptoms of dementia.1,2 The effect of concomitant cerebrovascular disease or cerebrovascular risk factors on the clinical course of Alzheimer’s disease is uncertain. Leukoaraiosis, the bilateral symmetrical white matter lucencies visible on computed tomography (CT), is common in very elderly people and in patients with vascular dementia and Alzheimer’s disease.3 Leukoaraiosis is more common among individuals with a prior history of stroke, or cardiovascular risk factors,3 which has prompted many to consider that leukoaraioisis is a radiological correlate of small vessel disease. There is little histopathological evidence to substantiate this and, indeed, the pathological correlates of leukoaraiosis are by no means clear and may well reflect several different processes.4,5 The aim of this longitudinal clinicopathological study was to examine the prevalence of leukoaraiosis on CT at presentation among histological subtypes of dementia and assess their relevance to clinical progression of dementia.

Association of Gestational Age With Verbal Ability and Spatial Working Memory at Age 11

Abstract: BACKGROUND: Although children born very preterm (gestation METHODS: Cognitive ability was assessed by using the Spatial Working Memory test from the Cambridge Neuropsychological Test Automated Working Battery ( n = 11 395) and British Ability Scale Verbal Similarities test ( n = 11 889) in the UK Millennium Cohort Study. Each gestational group was compared with the full-term group by using differences in z scores and odds ratios for delay (scoring ≥1 SD below the mean). RESULTS: Very and moderately preterm children demonstrated significantly lower working memory scores compared with full-term children (adjusted difference –0.2 to –0.6) and were more likely to be delayed. There was no significant relationship between late-preterm or early-term birth and working memory (adjusted differences CONCLUSIONS: Very preterm children exhibited working memory deficits at 11 years. However, the absence of delayed verbal skills at 11 years despite earlier delays could indicate “catch-up” effects.

Clinical Trials: Rethinking How We Ensure Quality

Abstract: This article is the version submitted to the publisher which was accepted without revision.