Clinical Trial Service Unit

About: Clinical Trial Service Unit is a based out in . It is known for research contribution in the topics: Population & Stroke. The organization has 428 authors who have published 1387 publications receiving 181920 citations.

Consumption of Tea, Alcohol, and Fruits and Risk of Kidney Stones: A Prospective Cohort Study in 0.5 Million Chinese Adults.

Abstract: A few prospective studies have suggested that tea, alcohol, and fruit consumption may reduce the risk of kidney stones However, little is known whether such associations and their combined effect persist in Chinese adults, for whom the popular tea and alcohol drinks are different from those investigated in the aforementioned studies The present study included 502,621 participants from the China Kadoorie Biobank (CKB) Information about tea, alcohol, and fruit consumption was self-reported at baseline The first documented cases of kidney stones during follow-up were collected through linkage with the national health insurance system Cox regression was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) During a median of 111 years of follow-up, we collected 12,407 cases of kidney stones After multivariable adjustment, tea, alcohol, and fruit consumption were found to be negatively associated with kidney stone risk, but the linear trend was only found in tea and fruit consumption Compared with non-tea consumers, the HR (95% CI) for participants who drank ≥7 cups of tea per day was 073 (065-083) Compared with non-alcohol consumers, the HR (95% CI) was 079 (072-087) for participants who drank pure alcohol of 300-599 g per day but had no further decrease with a higher intake of alcohol Compared with less-than-weekly consumers, the HR (95% CI) for daily fruit consumers was 081 (075-087) Even for those who did not drink alcohol excessively, increasing tea and fruit consumption could also independently reduce the stone risk Among Chinese adults, tea, alcohol, and fruit consumption was associated with a lower risk of kidney stones

How the NHS research governance procedures could be modified to greatly strengthen clinical research.

Abstract: Randomised controlled trials are the gold stan- dard for testing the efficacy and safety of health interventions, especially medications, and researchers in the UK are required to gain approval from ethics committees, the regulatory body (Medicines and Healthcare products Regulatory Agency) and local NHS research governance departments for such trials. Although research governance is important to reassure trial participants that their rights and interests are protected, cur- rent practice is impeding research and presents a genuine threat to the UK and to the NHS's ability to deliver high-quality evidence on which doctors can base clinical decisions and improve the delivery of care. This article discusses recent experience of running large-scale clinical trials and suggests measures that could improve the current situation.

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

Abstract: Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. By mapping and replicating protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, we identified 467 pQTLs for 85 proteins. The pQTLs were used in combination with other sources of information to evaluate known drug targets, and suggest new target candidates or repositioning opportunities, underpinned by a) causality assessment using Mendelian randomization, b) pathway mapping using trans-pQTL gene assignments, and c) protein-centric polygenic risk scores enabling matching of plausible target mechanisms to sub-groups of individuals enabling precision medicine.