Clinical Trial Service Unit

About: Clinical Trial Service Unit is a based out in . It is known for research contribution in the topics: Population & Stroke. The organization has 428 authors who have published 1387 publications receiving 181920 citations.

[Status of prevalence, awareness, treatment and controll on hypertension among adults in 10 regions, China].

Abstract: Objective To describe the status of prevalence, awareness, treatment, and control of hypertension among half a million adults in 10 regions under the China Kadoorie Biobank (CKB) cohort. Methods The baseline survey of CKB was performed in 10 areas across China during 2004-2008, included 512 891 adults aged from 30 to 79 years. Regional differences of prevalence, awareness, treatment and control of hypertension were compared after adjustment for age and/or sex. Results The overall prevalence of hypertension from the CKB was 35.2% (180 612/512 891), with the highest as 44.4% in Zhejiang and the lowest as 22.0% in Haikou. Prevalence in the rural areas (35.1%) was higher than that in the urban areas (32.1%), with statistical significance (P<0.001). Among all the participants with hypertension, 59 703 (33.1%) were aware of hypertension, 65 172 (36.1%) were receiving anti-hypertension treatment and 22 329 (12.4%) were under controll. However, only a small part of those receiving treatment were under controll (30.5%, 19 884/65 172) in this study. The control of hypertension and of those receiving treatment were higher in Suzhou for males (17.4%, 39.1%), while were higher in Liuzhou for females (23.5%, 42.6%) than those in other regions. Conclusions Participants under the CKB presented relatively high prevalence of hypertension, but lower rates on awareness, treatment and control of hypertension. Distribution of awareness, treatment, and control of hypertension varied greatly among the ten areas, under the CKB. Key words: Hypertension; Prevalence; Awareness rate; Treatment rate; Control rate; Regional difference

Resemblance of Symptoms for Major Depression Assessed at Interview versus from Hospital Record Review

Abstract: Background Diagnostic information for psychiatric research often depends on both clinical interviews and medical records. Although discrepancies between these two sources are well known, there have been few studies into the degree and origins of inconsistencies. Principal findings We compared data from structured interviews and medical records on 1,970 Han Chinese women with recurrent DSM-IV major depression (MD). Correlations were high for age at onset of MD (0.93) and number of episodes (0.70), intermediate for family history (+0.62) and duration of longest episode (+0.43) and variable but generally more modest for individual depressive symptoms (mean kappa = 0.32). Four factors were identified for twelve symptoms from medical records and the same four factors emerged from analysis of structured interviews. Factor congruencies were high but the correlation of factors between interviews and records were modest (i.e. +0.2 to +0.4). Conclusions Structured interviews and medical records are highly concordant for age of onset, and the number and length of episodes, but agree more modestly for individual symptoms and symptom factors. The modesty of these correlations probably arises from multiple factors including i) inconsistency in the definition of the worst episode, ii) inaccuracies in self-report and iii) difficulties in coding medical records where symptoms were recorded solely for clinical purposes.