Institution
Clinical Trial Service Unit
About: Clinical Trial Service Unit is a based out in . It is known for research contribution in the topics: Population & Stroke. The organization has 428 authors who have published 1387 publications receiving 181920 citations.
Papers published on a yearly basis
Papers
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TL;DR: The largest study ever undertaken to examine the health effects of tobacco finds that there are already a million deaths a year from smoking in China, and it predicts large increases in mortality over the next few decades.
Abstract: The largest study ever undertaken to examine the health effects of tobacco finds that there are already a million deaths a year from smoking in China, and it predicts large increases in mortality over the next few decades. This pattern is likely to be repeated in other developing countries.
196 citations
TL;DR: In a population at 2% average coronary event risk per year, cholesterol, apolipoprotein, and particle measures of LDL were strongly correlated and had similar predictive values for incident major occlusive vascular events.
Abstract: Background—Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are established risk factors for vascular disease, but lipoprotein particle concentrations may be stronger determinants of risk. Methods and Results—Associations between vascular events and baseline concentrations of cholesterol fractions, apolipoproteins B and A1, and lipoprotein particles assessed by nuclear magnetic resonance were considered in the Heart Protection Study randomized trial of simvastatin versus placebo (>5000 vascular events during 5.3 years of follow-up among 20 000 participants). Major occlusive coronary events were equally strongly associated with the cholesterol- and particle-based total LDL measures; adjusted hazard ratios per 1-SD-higher level were 1.25 (95% confidence interval [CI], 1.16–1.34) for LDL cholesterol, 1.22 (95% CI, 1.14–1.32) for non–HDL cholesterol, 1.23 (95% CI, 1.15–1.33) for apolipoprotein B, and 1.25 (95% CI, 1.16–1.35) for LDL particle number. Given the total LDL ...
194 citations
University of Copenhagen1, South China University of Technology2, University of California, San Francisco3, University of Nevada, Reno4, Chinese Academy of Sciences5, The Centre for Applied Genomics6, Clinical Trial Service Unit7, University of Cambridge8, Shenzhen University9, University of Washington10, Howard Hughes Medical Institute11, University of California, Berkeley12
TL;DR: It is shown that the present day distribution of alleles is a function of both ancient migration and very recent population movements, and a unique pattern of circulating viral DNA in plasma with high prevalence of hepatitis B and other clinically relevant maternal infections is identified.
193 citations
TL;DR: During a 1-year treatment period, simvastatin produced a sustained reduction of approximately one quarter in low-density lipoprotein cholesterol levels, with no evidence of toxicity, and aspirin, 100 mg/d, did not substantially increase the risk for a major bleeding episode.
192 citations
TL;DR: A deep-learning system that detects colorectal cancer specimens with dMMR or MSI using hematoxylin and eosin-stained slides is developed and might be used for high-throughput, low-cost evaluation of coloreCTal tissue specimens.
192 citations
Authors
Showing all 428 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Salim Yusuf | 231 | 1439 | 252912 |
| Richard Peto | 183 | 683 | 231434 |
| Cornelia M. van Duijn | 183 | 1030 | 146009 |
| Rory Collins | 162 | 489 | 193407 |
| Naveed Sattar | 155 | 1326 | 116368 |
| Timothy J. Key | 146 | 808 | 90810 |
| John Danesh | 135 | 394 | 100132 |
| Andrew J.S. Coats | 127 | 820 | 94490 |
| Valerie Beral | 114 | 471 | 53729 |
| Mike Clarke | 113 | 1037 | 164328 |
| Robert Clarke | 111 | 512 | 90049 |
| Robert U. Newton | 109 | 753 | 42527 |
| Richard Gray | 109 | 808 | 78580 |
| Braxton D. Mitchell | 102 | 558 | 49599 |
| Naomi E. Allen | 101 | 364 | 37057 |