Clinical Trial Service Unit

About: Clinical Trial Service Unit is a based out in . It is known for research contribution in the topics: Population & Stroke. The organization has 428 authors who have published 1387 publications receiving 181920 citations.

Sensible approaches for reducing clinical trial costs.

Abstract: Background Over the past decade, annual funding for biomedical research has more than doubled while new molecular entity approvals have declined by one third.Objective To assess the value of practices commonly employed in the conduct of large-scale clinical trials, and to identify areas where costs could be reduced without compromising scientific validity.Methods In the qualitative phase of the study, an expert panel recommended potential modifications of mega-trial designs and operations in order to maximize their value (cost versus scientific benefit tradeoff). In the quantitative phase, a mega-trial economic model was used to assess the financial implications of these recommendations. Our initial chronic disease trial design included 20,000 patients randomized at 1000 sites. Each site was assigned 24 monitoring visits and a $10,000 per patient site payment. The case report form (CRF) was 60 pages long, and trial duration was assumed to be 48 months.Results The total costs of the initial trial design we...

Consumption of spicy foods and total and cause specific mortality: population based cohort study

Abstract: ObjeCtive To examine the associations between the regular consumption of spicy foods and total and cause specific mortality. Design Population based prospective cohort study. s etting China Kadoorie Biobank in which participants from 10 geographically diverse areas across China were enrolled between 2004 and 2008.