Institution
Clinical Trial Service Unit
About: Clinical Trial Service Unit is a based out in . It is known for research contribution in the topics: Population & Stroke. The organization has 428 authors who have published 1387 publications receiving 181920 citations.
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Saarland University1, University of Jena2, Heidelberg University3, University of Utah4, University College London5, University of Ulm6, Technische Universität München7, German Cancer Research Center8, University of Helsinki9, Haukeland University Hospital10, University of Bergen11, Leiden University12, University of Glasgow13, University of Graz14, University of Otago15, National University of Singapore16, University of Auckland17, University of Florida18, Leipzig University19, Lund University20, University of Ottawa21, Washington University in St. Louis22, University of Missouri–Kansas City23, University of Verona24, University of Leicester25, Glenfield Hospital26, Emory University27, University of Southern California28, Cleveland Clinic29, Uppsala University30, Université de Montréal31, University of Western Ontario32, McGill University33, McGill University Health Centre34, Laval University35, Baylor College of Medicine36, The Texas Heart Institute37, University of Texas Health Science Center at Houston38, National Institute for Health Research39, Clinical Trial Service Unit40, University of Oxford41, Synlab Group42
TL;DR: In patients with prevalent coronary heart disease, lipoprotein(a) concentrations and genetic variants showed no associations with mortality, and it is concluded that these variables are not useful risk factors to measure to predict progression to death after coronaryHeart disease is established.
80 citations
TL;DR: A meta-analysis found no significant association with CHD risk using a recessive model and only a modest association using a dominant model (with narrow confidence intervals around these risk estimates).
Abstract: Lymphotoxin-α (LTA) is a pro-inflammatory cytokine that plays an important role in the immune system and local inflammatory response. LTA is expressed in atherosclerotic plaques and has been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Polymorphisms in the gene encoding lymphotoxin-α (LTA) on Chromosome 6p21 have been associated with susceptibility to CHD, but results in different studies appear to be conflicting. We examined the association of seven single nucleotide polymorphisms (SNPs) across the LTA gene, and their related haplotypes, with risk of myocardial infarction (MI) in the International Study of Infarct Survival (ISIS) case-control study involving 6,928 non-fatal MI cases and 2,712 unrelated controls. The seven SNPs (including the rs909253 and rs1041981 SNPs previously implicated in the risk of CHD) were in strong linkage disequilibrium with each other and contributed to six common haplotypes. Some of the haplotypes for LTA were associated with higher plasma concentrations of C-reactive protein (p = 0.004) and lower concentrations of albumin (p = 0.023). However, none of the SNPs or related haplotypes were significantly associated with risk of MI. The results of the ISIS study were considered in the context of six previously published studies that had assessed this association, and this meta-analysis found no significant association with CHD risk using a recessive model and only a modest association using a dominant model (with narrow confidence intervals around these risk estimates). Overall, these studies provide reliable evidence that these common polymorphisms for the LTA gene are not strongly associated with susceptibility to coronary disease.
80 citations
TL;DR: Household Air Pollution from biomass cooking fuels is a major cause of morbidity and mortality in low-income settings worldwide and in Nepal the use of open stoves with solid biomass fuels is the primary method of domestic cooking.
79 citations
TL;DR: Lymph node inclusion and IMRT use increased exposure, while breathing adaptation and prone/lateral decubitus positioning reduced it, while lung doses from breast cancer radiotherapy varied substantially worldwide.
79 citations
TL;DR: It is suggested that the increasing intake of animal fat and/or protein may have played a key role in reducing cerebrovascular disease in Japan.
79 citations
Authors
Showing all 428 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Salim Yusuf | 231 | 1439 | 252912 |
| Richard Peto | 183 | 683 | 231434 |
| Cornelia M. van Duijn | 183 | 1030 | 146009 |
| Rory Collins | 162 | 489 | 193407 |
| Naveed Sattar | 155 | 1326 | 116368 |
| Timothy J. Key | 146 | 808 | 90810 |
| John Danesh | 135 | 394 | 100132 |
| Andrew J.S. Coats | 127 | 820 | 94490 |
| Valerie Beral | 114 | 471 | 53729 |
| Mike Clarke | 113 | 1037 | 164328 |
| Robert Clarke | 111 | 512 | 90049 |
| Robert U. Newton | 109 | 753 | 42527 |
| Richard Gray | 109 | 808 | 78580 |
| Braxton D. Mitchell | 102 | 558 | 49599 |
| Naomi E. Allen | 101 | 364 | 37057 |