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Institution

Cochin University of Science and Technology

EducationKochi, Kerala, India
About: Cochin University of Science and Technology is a education organization based out in Kochi, Kerala, India. It is known for research contribution in the topics: Thin film & Natural rubber. The organization has 5382 authors who have published 7690 publications receiving 103827 citations. The organization is also known as: CUSAT & Cochin University.


Papers
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Journal ArticleDOI
TL;DR: TLR2 stimulation by Staphylococcus aureus induces a fast and transient activation of the Rho GTPases Rac1 and Cdc42 in the human monocytic cell line THP-1 and in 293 cells expressing TLR2, and Rac1 controls a second, IκB–independent, pathway to NF-κB activation and is essential in innate immune cell signaling via TLR 2.
Abstract: Mammalian Toll-like receptors (TLRs) are expressed on innate immune cells and respond to the membrane components of Gram-positive or Gram-negative bacteria. When activated, they convey signals to transcription factors that orchestrate the inflammatory response. However, the intracellular signaling events following TLR activation are largely unknown. Here we show that TLR2 stimulation by Staphylococcus aureus induces a fast and transient activation of the Rho GTPases Rac1 and Cdc42 in the human monocytic cell line THP-1 and in 293 cells expressing TLR2. Dominant-negative Rac1N17, but not dominant-negative Cdc42N17, block nuclear factor-κB (NF-κB) transactivation. S. aureus stimulation causes the recruitment of active Rac1 and phosphatidylinositol-3 kinase (PI3K) to the TLR2 cytosolic domain. Tyrosine phosphorylation of TLR2 is required for assembly of a multiprotein complex that is necessary for subsequent NF-κB transcriptional activity. A signaling cascade composed of Rac1, PI3K and Akt targets nuclear p65 transactivation independently of IκBα degradation. Thus Rac1 controls a second, IκB–independent, pathway to NF-κB activation and is essential in innate immune cell signaling via TLR2.

653 citations

Journal ArticleDOI
01 Sep 1989-Nature
TL;DR: In this article, the authors used regional patterns of present-day tectonic stress to evaluate the forces acting on the lithosphere and to investigate intraplate seismicity, and found that most intraplate regions are characterized by a compressional stress regime; extension is limited almost entirely to thermally uplifted regions.
Abstract: Regional patterns of present-day tectonic stress can be used to evaluate the forces acting on the lithosphere and to investigate intraplate seismicity. Most intraplate regions are characterized by a compressional stress regime; extension is limited almost entirely to thermally uplifted regions. In several plates the maximum horizontal stress is subparallel to the direction of absolute plate motion, suggesting that the forces driving the plates also dominate the stress distribution in the plate interior.

587 citations

Journal ArticleDOI
TL;DR: Safety training was identified as the most important safety management practice that predicts safety knowledge, safety motivation, safety compliance and safety participation and path analysis using AMOS-4 software showed that some of the safety management practices have direct and indirect relations with the safety performance components.

505 citations

Journal ArticleDOI
TL;DR: In this article, the effect of grain size on NiFe 2 O 4 nanoparticles has been studied in detail using X-ray diffraction (XRD) data and the strain graph and it was found that the specific magnetization of the nanosized NiFe O 4 powders was lower than that of the corresponding coarse-grained counterparts and decreased with a decrease in grain size.

435 citations

Journal ArticleDOI
TL;DR: In this paper, the authors presented the results from an experimental program and an analytical assessment of the influence of addition of fibers on mechanical properties of concrete, which is at variance with both existing models and formulations based on the law of mixtures.
Abstract: This paper presents the results from an experimental program and an analytical assessment of the influence of addition of fibers on mechanical properties of concrete. Models derived based on the regression analysis of 60 test data for various mechanical properties of steel fiber-reinforced concrete have been presented. The various strength properties studied are cube and cylinder compres- sive strength, split tensile strength, modulus of rupture and postcracking performance, modulus of elasticity, Poisson's ratio, and strain corresponding to peak compressive stress. The variables considered are grade of concrete, namely, normal strength 35 MPa, moderately high strength 65 MPa, and high-strength concrete 85 MPa, and the volume fraction of the fiber Vf=0.0, 0.5, 1.0, and 1.5%. The strength of steel fiber-reinforced concrete predicted using the proposed models have been compared with the test data from the present study and with various other test data reported in the literature. The proposed model predicted the test data quite accurately. The study indicates that the fiber matrix interaction contributes significantly to enhancement of mechanical properties caused by the introduction of fibers, which is at variance with both existing models and formulations based on the law of mixtures. 85 MPa with various fiber dosages Vf=0, 0.5, 1.0, and 1.5%. An empirical relationship for various mechanical properties of SFRC has been proposed. The proposed model attempts to bring out the significance of fiber matrix interaction in all the strength properties. This study reports the experimental results of the strength properties of SFRC, namely, cube and cylinder compressive strength, split tensile strength, modulus of rupture, modulus of elasticity, Poisson's ratio, and strain corresponding to peak com- pressive stress. Empirical relationships were developed for vari- ous strength properties based on the regression analysis of the 60 test data. It is expected that these proposed models would be helpful in assessing the strength properties of fiber-reinforced concrete based on the matrix strength and fiber-RI.

410 citations


Authors

Showing all 5433 results

NameH-indexPapersCitations
Sophie Grabar441369446
Luc Baert432606301
Yasuhiko Yoshida432469340
Anh Tuan Dinh-Xuan431977724
Jean-Daniel Chiche4311116904
Reji Philip412495926
Tharangattu N. Narayanan411635115
M. R. Anantharaman401604869
Manikoth M. Shaijumon40857155
Taihyun Chang40874951
Anne Caignard391185161
Sandrine Barbaux39775368
Jérôme Alexandre392309289
Jerome Tamburini381359567
Harsh K. Gupta371545050
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202318
2022106
2021753
2020613
2019503
2018439